Neumora Therapeutics Scraps Lead Asset Navacaprant After Study Failures

Dow Jones

06/15

By Colin Kellaher

Neumora Therapeutics is throwing in the towel on navacaprant following the failure of its lead drug candidate in a pair of late-stage studies.

Neumora on Monday said navacaprant didn't achieve statistical significance on the primary or key secondary endpoints in two Phase 3 studies in major depressive disorder.

The Watertown, Mass., clinical-stage biopharmaceutical company said it plans to slash 35% of its workforce as it focuses on advancing the rest of its portfolio.

Neumora said it expects the job cuts to result in $10 million of annual savings, adding that its current cash and equivalents provide a runway into the third quarter of 2027.

Trading in shares of Neumora, which closed Friday at $1.78, was halted premarket on Monday.

Write to Colin Kellaher at colin.kellaher@wsj.com

(END) Dow Jones Newswires

June 15, 2026 08:40 ET (12:40 GMT)

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Company, Inc.\n</p>\n</font>\n\n</article>\n</div>\n</body>\n</html>\n","isBrief":false,"type":0,"news_type":1,"symbol":"NMRA","symbol_name":"Neumora Therapeutics, Inc.","start_time":0,"source_url":"https://dowjonesnews.com/newdjn/logon.aspx?AL=N","article_id":"2643205965","we_media_id":"106","thumbnails":[],"rights":null,"url":"https://stock-news.laohu8.com/highlight/detail?id=2643205965","pubTimestamp":1781527200,"columns":[],"sourceInfo":null,"weMediaInfo":{"media_name":"Dow Jones","introduction":"Dow Jones publishes the world’s most trusted business news and financial information in a variety of media.","home_visible":0,"id":"106","head_image":"https://static.tigerbbs.com/150f88aa4d182df19190059f4a365e99"},"summary":"Neumora Therapeutics is throwing in the towel on navacaprant following the failure of its lead drug candidate in a pair of late-stage studies.Neumora on Monday said navacaprant didn't achieve statistical significance on the primary or key secondary endpoints in two Phase 3 studies in major depressive disorder.The Watertown, Mass., clinical-stage biopharmaceutical company said it plans to slash 35% of its workforce as it focuses on advancing the rest of its portfolio.Neumora said it expects the job cuts to result in $10 million of annual savings, adding that its current cash and equivalents provide a runway into the third quarter of 2027.Trading in shares of Neumora, which closed Friday at $1.78, was halted premarket on Monday.","collect":0,"end_time":0,"defaultTopTitle":"","property":[],"viewcount":null,"language":"en","relate_stocks":{"NMRA":"Neumora Therapeutics, Inc.","BK4007":"制药","DBB":"基础金属ETF-PowerShares"},"translate_title":"Neumora Therapeutics在研究失败后废弃主要资产Navacaprant","themeId":null,"isJumpTheme":false,"ttsUrl":null,"symbols_score_info":{"NMRA":1.5,"DBB":1.5},"content_text":"By Colin Kellaher \n\n\n \n\n\n  Neumora Therapeutics is throwing in the towel on navacaprant following the failure of its lead drug candidate in a pair of late-stage studies. \n\n\n  Neumora on Monday said navacaprant didn't achieve statistical significance on the primary or key secondary endpoints in two Phase 3 studies in major depressive disorder. \n\n\n  The Watertown, Mass., clinical-stage biopharmaceutical company said it plans to slash 35% of its workforce as it focuses on advancing the rest of its portfolio. \n\n\n  Neumora said it expects the job cuts to result in $10 million of annual savings, adding that its current cash and equivalents provide a runway into the third quarter of 2027. \n\n\n  Trading in shares of Neumora, which closed Friday at $1.78, was halted premarket on Monday. \n\n\n \n\n\n  Write to Colin Kellaher at colin.kellaher@wsj.com \n\n\n \n\n\n  (END) Dow Jones Newswires\n\n\n  June 15, 2026 08:40 ET (12:40 GMT)\n\n\n  Copyright (c) 2026 Dow Jones & Company, Inc.","kind":"highlight","is_publish_news":true,"is_publish_highlight":false,"is_publish_live":false,"is_publish_wemedia":true,"editions":null,"column":"","sentiment":"-2","news_tag":"productRelease","news_rank":0,"isVideo":false,"video":null,"symbols":[],"gpt_button":0,"need_auth":true,"need_login_tip":false,"code":"91000000","status":"200"}}}