Astrazeneca Non-oncology Trial Failure is Unexpected

Dow Jones

07/09

0754 GMT - AstraZeneca's negative headline results for its Wainua drug trial are unexpected, analysts at Bernstein say in a note. The U.K. drugmaker said the trial evaluating Wainua for transthyretin amyloid cardiomyopathy, a rare heart disease, didn't meet its primary objective. "We've just spoken to AZN who are extremely and disappointed surprised by this news," the analysts say. "We are too." The company recently doubled the trial size to 1,400 patients to increase the chances of positive, statistically rigorous results on the primary endpoint in the total population, Bernstein says. Shares fall 8.9%. (andrea.figueras@wsj.com)

(END) Dow Jones Newswires

July 09, 2026 03:54 ET (07:54 GMT)

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The U.<a href=\"https://laohu8.com/S/TKKD.SI\">K</a>. drugmaker said the trial evaluating Wainua for transthyretin amyloid cardiomyopathy, a rare heart disease, didn't meet its primary objective. \"We've just spoken to AZN who are extremely and disappointed surprised by this news,\" the analysts say. \"We are too.\" The company recently doubled the trial size to 1,400 patients to increase the chances of positive, statistically rigorous results on the primary endpoint in the total population, Bernstein says. Shares fall 8.9%. (andrea.figueras@wsj.com) \n</p>\n<pre style=\"white-space: pre\">\n \n</pre>\n<p>\n  (END) Dow Jones Newswires\n</p>\n<p>\n  July 09, 2026 03:54 ET (07:54 GMT)\n</p>\n<p>\n  Copyright (c) 2026 Dow Jones &amp; Company, Inc.\n</p>\n</font>","source":null,"html":"<!DOCTYPE html>\n<html>\n<head>\n<meta http-equiv=\"Content-Type\" content=\"text/html; charset=utf-8\" />\n<meta name=\"viewport\" content=\"width=device-width,initial-scale=1.0,minimum-scale=1.0,maximum-scale=1.0,user-scalable=no\"/>\n<meta name=\"format-detection\" content=\"telephone=no,email=no,address=no\" />\n<title>Astrazeneca Non-oncology Trial Failure is Unexpected</title>\n<style type=\"text/css\">\na,abbr,acronym,address,applet,article,aside,audio,b,big,blockquote,body,canvas,caption,center,cite,code,dd,del,details,dfn,div,dl,dt,\nem,embed,fieldset,figcaption,figure,footer,form,h1,h2,h3,h4,h5,h6,header,hgroup,html,i,iframe,img,ins,kbd,label,legend,li,mark,menu,nav,\nobject,ol,output,p,pre,q,ruby,s,samp,section,small,span,strike,strong,sub,summary,sup,table,tbody,td,tfoot,th,thead,time,tr,tt,u,ul,var,video{ font:inherit;margin:0;padding:0;vertical-align:baseline;border:0 }\nbody{ font-size:16px; line-height:1.5; color:#999; background:transparent; }\n.wrapper{ overflow:hidden;word-break:break-all;padding:10px; }\nh1,h2{ font-weight:normal; line-height:1.35; margin-bottom:.6em; }\nh3,h4,h5,h6{ line-height:1.35; margin-bottom:1em; }\nh1{ font-size:24px; }\nh2{ font-size:20px; }\nh3{ font-size:18px; }\nh4{ font-size:16px; }\nh5{ font-size:14px; }\nh6{ font-size:12px; }\np,ul,ol,blockquote,dl,table{ margin:1.2em 0; }\nul,ol{ margin-left:2em; }\nul{ list-style:disc; }\nol{ list-style:decimal; }\nli,li p{ margin:10px 0;}\nimg{ max-width:100%;display:block;margin:0 auto 1em; }\nblockquote{ color:#B5B2B1; border-left:3px solid #aaa; padding:1em; }\nstrong,b{font-weight:bold;}\nem,i{font-style:italic;}\ntable{ width:100%;border-collapse:collapse;border-spacing:1px;margin:1em 0;font-size:.9em; }\nth,td{ padding:5px;text-align:left;border:1px solid #aaa; }\nth{ font-weight:bold;background:#5d5d5d; }\n.symbol-link{font-weight:bold;}\n/* header{ border-bottom:1px solid #494756; } */\n.title{ margin:0 0 8px;line-height:1.3;color:#ddd; }\n.meta {color:#5e5c6d;font-size:13px;margin:0 0 .5em; }\na{text-decoration:none; color:#2a4b87;}\n.meta .head { display: inline-block; overflow: hidden}\n.head .h-thumb { width: 30px; height: 30px; margin: 0; padding: 0; border-radius: 50%; float: left;}\n.head .h-content { margin: 0; padding: 0 0 0 9px; float: left;}\n.head .h-name {font-size: 13px; color: #eee; margin: 0;}\n.head .h-time {font-size: 11px; color: #7E829C; margin: 0;line-height: 11px;}\n.small {font-size: 12.5px; display: inline-block; transform: scale(0.9); -webkit-transform: scale(0.9); transform-origin: left; -webkit-transform-origin: left;}\n.smaller {font-size: 12.5px; display: inline-block; transform: scale(0.8); -webkit-transform: scale(0.8); transform-origin: left; -webkit-transform-origin: left;}\n.bt-text {font-size: 12px;margin: 1.5em 0 0 0}\n.bt-text p {margin: 0}\n</style>\n</head>\n<body>\n<div class=\"wrapper\">\n<header>\n<h2 class=\"title\">\nAstrazeneca Non-oncology Trial Failure is Unexpected\n</h2>\n\n<h4 class=\"meta\">\n\n\n<div class=\"head\" \">\n\n\n<div class=\"h-thumb\" style=\"background-image:url(https://static.tigerbbs.com/150f88aa4d182df19190059f4a365e99);background-size:cover;\"></div>\n\n<div class=\"h-content\">\n<p class=\"h-name\">Dow Jones </p>\n<p class=\"h-time\">2026-07-09 15:54</p>\n</div>\n\n</div>\n\n\n</h4>\n\n</header>\n<article>\n<font class=\"NormalMinus1\" face=\"Arial\">\n<p>\n     0754 GMT - AstraZeneca's negative headline results for its Wainua drug trial are unexpected, analysts at Bernstein say in a note. The U.<a href=\"https://laohu8.com/S/TKKD.SI\">K</a>. drugmaker said the trial evaluating Wainua for transthyretin amyloid cardiomyopathy, a rare heart disease, didn't meet its primary objective. \"We've just spoken to AZN who are extremely and disappointed surprised by this news,\" the analysts say. \"We are too.\" The company recently doubled the trial size to 1,400 patients to increase the chances of positive, statistically rigorous results on the primary endpoint in the total population, Bernstein says. Shares fall 8.9%. (andrea.figueras@wsj.com) \n</p>\n<pre style=\"white-space: pre\">\n \n</pre>\n<p>\n  (END) Dow Jones Newswires\n</p>\n<p>\n  July 09, 2026 03:54 ET (07:54 GMT)\n</p>\n<p>\n  Copyright (c) 2026 Dow Jones &amp; Company, Inc.\n</p>\n</font>\n\n</article>\n</div>\n</body>\n</html>\n","isBrief":false,"type":0,"news_type":1,"symbol":"LU2417539215.USD","symbol_name":"ALLIANZ GLOBAL INCOME \"AMF\" (USD) INC","start_time":0,"source_url":"https://dowjonesnews.com/newdjn/logon.aspx?AL=N","article_id":"2650294427","we_media_id":"106","thumbnails":[],"rights":null,"url":"https://stock-news.laohu8.com/highlight/detail?id=2650294427","pubTimestamp":1783583640,"columns":[],"sourceInfo":null,"weMediaInfo":{"media_name":"Dow Jones","introduction":"Dow Jones publishes the world’s most trusted business news and financial information in a variety of media.","home_visible":0,"id":"106","head_image":"https://static.tigerbbs.com/150f88aa4d182df19190059f4a365e99"},"summary":"0754 GMT - AstraZeneca's negative headline results for its Wainua drug trial are unexpected, analysts at Bernstein say in a note. The U.K. drugmaker said the trial evaluating Wainua for transthyretin amyloid cardiomyopathy, a rare heart disease, didn't meet its primary objective. \"We've just spoken to AZN who are extremely and disappointed surprised by this news,\" the analysts say. \"We are too.\" The company recently doubled the trial size to 1,400 patients to increase the chances of positive, statistically rigorous results on the primary endpoint in the total population, Bernstein says. Shares fall 8.9%.  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The U.K. drugmaker said the trial evaluating Wainua for transthyretin amyloid cardiomyopathy, a rare heart disease, didn't meet its primary objective. \"We've just spoken to AZN who are extremely and disappointed surprised by this news,\" the analysts say. \"We are too.\" The company recently doubled the trial size to 1,400 patients to increase the chances of positive, statistically rigorous results on the primary endpoint in the total population, Bernstein says. Shares fall 8.9%. (andrea.figueras@wsj.com) \n\n\n \n\n\n  (END) Dow Jones Newswires\n\n\n  July 09, 2026 03:54 ET (07:54 GMT)\n\n\n  Copyright (c) 2026 Dow Jones & Company, Inc.","kind":"highlight","is_publish_news":true,"is_publish_highlight":false,"is_publish_live":false,"is_publish_wemedia":true,"editions":null,"column":"","sentiment":"-1","news_tag":"","news_rank":0,"isVideo":false,"video":null,"symbols":[],"gpt_button":0,"need_auth":true,"need_login_tip":false,"code":"91000000","status":"200"}}}