HeartFlow Inc's stock experienced a significant after-hours plunge of 5.18% following the release of its fourth quarter and full year 2025 financial results.

The company reported an adjusted loss of $0.12 per share for the quarter, which was better than the $0.17 loss anticipated by analysts. Revenue also exceeded expectations, coming in at $49.1 million compared to the estimated $46.6 million, representing a 40% year-over-year increase.

Despite these positive beats, the company continues to operate at a loss, with a net loss of $24.4 million for the quarter. Investors may be reacting to concerns about ongoing profitability challenges despite revenue growth, or potentially to the company's 2026 revenue guidance of $218-222 million, which while above analyst expectations, may not have met some investors' more optimistic projections.