HeartFlow Inc (HTFL) experienced a significant 5.46% decline in after-hours trading on Wednesday, following the release of its fourth quarter and full year 2025 financial results.

The company reported an adjusted loss of $0.12 per share for the quarter, which was better than the $0.17 loss anticipated by analysts. Revenue also exceeded expectations, coming in at $49.1 million compared to the estimated $46.6 million, representing a 40% year-over-year increase. Despite these positive beats, the stock price moved lower as investors focused on the company's ongoing profitability challenges.

Market participants appear to be reacting to concerns about HeartFlow's continued net loss of $24.4 million for the quarter, as well as the company's 2026 revenue guidance of $218-222 million, which while above analyst expectations, may not have met some investors' more optimistic projections for the AI-driven cardiovascular care technology company.