Press Release: SOPHiA GENETICS Reports First Quarter 2025 Results

Dow Jones
05-06

SOPHiA GENETICS Reports First Quarter 2025 Results

PR Newswire

BOSTON and ROLLE, Switzerland, May 6, 2025

BOSTON and ROLLE, Switzerland, May 6, 2025 /PRNewswire/ -- SOPHiA GENETICS (Nasdaq: SOPH), a cloud-native software company and leader in data-driven medicine, today reported financial results for the first quarter ended March 31, 2025.

First Quarter 2025 Financial Results

   -- Revenue was $17.8 million, up 13% year-over-year or 15% on a constant 
      currency basis 
 
   -- Gross margin was 68.7% on a reported basis and 75.7% on an adjusted basis, 
      up from 65.9% and 70.5% in the prior year period, respectively 
 
   -- IFRS net loss increased 27% year-over-year to $17.4 million (including a 
      net foreign exchange P&L impact of $5.2 million), and adjusted EBITDA 
      loss improved 24% year-over-year to $9.8 million 
 
   -- The company reiterates full-year guidance of revenue between $72 million 
      and $76 million and adjusted EBITDA loss between $35 million and $39 
      million 

"We started the year strong with year-over-year revenue growth of 13%, or 15% on a constant currency basis, as the large amount of new business signed in 2024 begins to ramp," said Jurgi Camblong, PhD., Chief Executive Officer and Co-founder. "In addition to reaccelerating topline growth, we also continued to optimize SOPHiA DDM$(TM)$'s data processing capabilities and delivered a record adjusted gross margin of 75.7%, up 520bps year-over-year. Prudent cost management across all spending categories resulted in a 24% year-over-year improvement to adjusted EBITDA loss during the period, demonstrating steady progress on our path to profitability."

Camblong added, "Looking ahead, we remain confident in our long-term growth and in the growth prospects of our end markets. New business momentum remains strong, driven by notable catalysts such as the new Liquid Biopsy application MSK-ACCESS$(R)$ powered with SOPHiA DDM(TM), a relatively underpenetrated U.S. market where revenue from core genomics customers grew over 30%, and a large base of new customers to onboard and expand over the remainder of 2025."

First Quarter 2025 Business Highlights

Expanding usage of SOPHiA DDM(TM) worldwide

   -- Performed 93,000 analyses on SOPHiA DDM(TM), representing 11% 
      year-over-year volume growth 
 
   -- Reached 490 core genomics customers as of March 31, 2025, up from 463 
      customers at the end of Q1 2024 
 
   -- Completed implementation for 33 new core genomics customers during Q1 
      2025, up from an average of 23 customers implemented per quarter in 2024 
 
   -- Delivered strong analysis volume growth in NORAM and APAC with 32% and 
      40% year-over-year growth, respectively 
 
   -- Hit a major Platform milestone during Q1, passing 2 million cumulative 
      genomic profiles analyzed by SOPHiA DDM(TM) since inception 

Landing new customers to fuel future platform growth

   -- Landed 28 new core genomics customers in Q1 2025 who will implement 
      SOPHiA DDM(TM) and begin generating revenue over the next twelve months, 
      up from 20 new customers signed in Q1 2024 
 
   -- Signed major new customers across geographies including Jessa Ziekenhuis 
      in Belgium who is adopting SOPHiA DDM(TM) for Solid Tumor, Liquid Biopsy, 
      and HemOnc testing; LifeLabs, a central reference lab in Canada, who is 
      adopting Solid Tumor applications; and Premier Integrated Labs in 
      Malaysia who is adopting numerous applications in Hereditary Cancer, 
      HemOnc, and Inherited Disorders, in addition to MSK-ACCESS(R) powered 
      with SOPHiA DDM(TM) 

Building strong new business momentum with new applications

   -- Expanded the October 2024 collaboration with AstraZeneca to accelerate 
      the deployment of MSK-ACCESS(R) powered with SOPHiA DDM(TM) globally, 
      extending the scope to 30 total sponsored institutions worldwide 
 
   -- Recently signed new customers to the Liquid Biopsy application 
      MSK-ACCESS(R) powered with SOPHiA DDM(TM), including Kuwait Cancer 
      Control Center; Centre Hospitalier Régional Universitaire de Nancy 
      in Nancy, France; and Hospital de Amor in Barretos, Brazil 
 
   -- Continued to drive significant demand for MSK-ACCESS(R) and MSK-IMPACT(R) 
      powered with SOPHiA DDM(TM), with a healthy and growing pipeline of more 
      than 60 identified opportunities 

Continued driving strong business growth in the U.S. market

   -- Delivered over 30% year-over-year revenue growth from U.S. core genomics 
      customers in Q1 
 
   -- Expanded our partnerships with two top-ranked U.S. hospitals, including 
      Henry Ford Hospital who is adopting additional Solid Tumor and HemOnc 
      applications on SOPHiA DDM(TM) and the Mayo Clinic who is adopting HemOnc 
      applications 
 
   -- Signed Mount Sinai during Q1, one of the leading hospital systems in the 
      world based in New York City, who is adopting HemOnc and Solid Tumor 
      applications 

Growing sustainably by maintaining an obsession with operational excellence

   -- Achieved a record 75.7% adjusted gross margin, up 520bps year-over-year, 
      by continuing to optimize compute costs and leverage the scale of the 
      cloud-native SOPHiA DDM(TM) platform 
 
   -- Remained laser-focused on operational excellence and cost containment and 
      improved adjusted EBITDA loss by 24% year-over-year to $9.8 million 
 
   -- The Company reaffirms commitment to profitable growth and expects to be 
      approaching adjusted EBITDA breakeven by the end of 2026 and crossing 
      over to positive adjusted EBITDA in the second half of 2027 

2025 Financial Outlook

Based on information as of today, SOPHiA GENETICS is reaffirming the previously provided guidance of:

   -- Full-year revenue between $72 million and $76 million, representing 
      growth of approximately 10% to 17% compared to FY 2024 
 
   -- Adjusted EBITDA loss between $35 million and $39 million, compared to 
      $40.2 million in FY 2024 

Non-IFRS Financial Measures

Other than with respect to revenue, the Company only provides guidance on a non-IFRS basis. The Company does not provide a reconciliation of forward-looking adjusted gross margin (non-IFRS measure) to gross margin (the most comparable IFRS financial measure), due to the inherent difficulty in forecasting and quantifying amortization of capitalized research & development expenses that are necessary for such reconciliation. In addition, the Company does not provide a reconciliation of forward-looking adjusted operating loss (non-IFRS measure) to operating loss (the most comparable IFRS financial measure), due to the inherent difficulty in forecasting and quantifying amortization of capitalized research & development expenses and intangible assets, share-based compensation expenses, and non-cash portion of pensions paid in excess of actual contributions, that are necessary for such reconciliation.

To provide investors with additional information regarding the company's financial results, SOPHiA GENETICS has disclosed here and elsewhere in this earnings release the following non-IFRS measures:

   -- Adjusted gross profit, which the company calculates as revenue minus cost 
      of revenue adjusted to exclude amortization of capitalized research and 
      development expenses; 
 
   -- Adjusted gross profit margin, which the company calculates as adjusted 
      gross profit as a percentage of revenue; 
 
   -- Adjusted operating loss, which the company calculates as operating loss 
      adjusted to exclude amortization of capitalized research and development 
      expenses, amortization of intangible assets, share-based compensation 
      expense, and non-cash portion of pensions expense paid in excess of 
      actual contributions to match the actuarial expense. 
 
   -- EBITDA, which the company calculates as loss for the year before 
      depreciation, amortization, interest income, interest expense, fair value 
      adjustments on warrant obligations, foreign exchange (losses) gains, net, 
      and income tax (expense) benefit; and 
 
   -- Adjusted EBITDA, which the company calculates as EBITDA adjusted to 
      exclude share-based compensation expense, non-cash pension expenses, and 
      costs associated with restructuring. 

These non-IFRS measures are key measures used by SOPHiA GENETICS management and board of directors to evaluate its operating performance and generate future operating plans. The exclusion of certain expenses facilitates operating performance comparability across reporting periods by removing the effect of non-cash expenses and certain variable charges. Accordingly, the company believes that these non-IFRS measures provide useful information to investors and others in understanding and evaluating its operating results in the same manner as its management and board of directors.

These non-IFRS measures have limitations as financial measures, and you should not consider them in isolation or as a substitute for analysis of SOPHiA GENETICS' results as reported under IFRS. Some of these limitations are:

   -- These non-IFRS measures exclude the impact of depreciation. Although 
      depreciation is a non-cash charge, the assets being depreciated may need 
      to be replaced in the future and these non-IFRS measures do not reflect 
      capital expenditure requirements for such replacements or for new capital 
      expenditures; 
 
   -- These non-IFRS measures exclude the impact of interest expense. Interest 
      expense will continue to be for the foreseeable future a recurring 
      expense based on the company's financial liabilities; 
 
   -- These non-IFRS measures exclude the impact of interest income. Interest 
      income will continue to be for the foreseeable future recurring income 
      based on the company's financial assets; 
 
   -- These non-IFRS measures exclude the impact of income taxes. Income taxes 
      will continue to be for the foreseeable future a recurring expense 
      incurred in the various jurisdictions in which the company operates; 
 
   -- These non-IFRS measures exclude the impact of foreign exchange gains 
      (losses),net. Foreign exchange gains and losses will continue to be for 
      the foreseeable future a recurring expense incurred as the company 
      participates in transactions outside of the company's functional 
      currency; 
 
   -- These non-IFRS measures exclude the impact of fair value adjustments of 
      warrant obligations. Fair value adjustments on warrant obligations will 
      continue to be for the foreseeable future a recurring expense incurred as 
      the company has outstanding warrant obligations; 
 
   -- These non-IFRS measures exclude the impact of amortization of capitalized 
      research and development expenses and intangible assets. Although 
      amortization is a non-cash charge, the assets being amortized may need to 
      be replaced in the future and these non-IFRS measures do not reflect 
      capital expenditure requirements for such replacements or for new capital 
      expenditures; 
 
   -- These non-IFRS measures exclude the impact of share-based compensation 
      expenses. Share-based compensation has been, and will continue to be for 
      the foreseeable future, a recurring expense in the company's business and 
      an important part of its compensation strategy; 
 
   -- These non-IFRS measures exclude the impact of the non-cash portion of 
      pensions paid in excess of actual contributions to match actuarial 
      expenses. Pension expenses have been, and will continue to be for the 
      foreseeable future, a recurring expense in the business; and 
 
   -- Other companies, including companies in the company's industry, may 
      calculate these non-IFRS measures differently, which reduces their 
      usefulness as comparative measures. 

Because of these limitations, you should consider these non-IFRS measures alongside other financial performance measures, including various cash flow metrics, net income and other IFRS results.

The tables below provide the reconciliation of the most comparable IFRS measures to the non-IFRS measures for the periods presented.

Presentation of Constant Currency Revenue

SOPHiA GENETICS operates internationally, and its revenues are generated primarily in the U.S. dollar, the euro and Swiss franc and, to a lesser extent, British pound, Australian dollar, Brazilian real, Turkish lira and Canadian dollar depending on the company's customers' geographic locations. Changes in revenue include the impact of changes in foreign currency exchange rates. We present the non-IFRS financial measure "constant currency revenue" (or similar terms such as constant currency revenue growth) to show changes in revenue without giving effect to period-to-period currency fluctuations. Under IFRS, revenues received in local (non-U.S. dollar) currencies are translated into U.S. dollars at the average monthly exchange rate for the month in which the transaction occurred. When the company uses the term "constant currency", it means that it has translated local currency revenues for the current reporting period into U.S. dollars using the same average foreign currency exchange rates for the conversion of revenues into U.S. dollars that we used to translate local currency revenues for the comparable reporting period of the prior year. The company then calculates the difference between the IFRS revenue and the constant currency revenue to yield the "constant currency impact" for the current period.

The company's management and board of directors use constant currency revenue growth to evaluate growth and generate future operating plans. The exclusion of the impact of exchange rate fluctuations provides comparability across reporting periods and reflects the effects of customer acquisition efforts and land-and-expand strategy. Accordingly, it believes that this non-IFRS measure provides useful information to investors and others in understanding and evaluating revenue growth in the same manner as the management and board of directors. However, this non-IFRS measure has limitations, particularly as the exchange rate effects that are eliminated could constitute a significant element of its revenue and could significantly impact performance and prospects. Because of these limitations, you should consider this non-IFRS measure alongside other financial performance measures, including revenue and revenue growth presented in accordance with IFRS and other IFRS results.

The table below provides the reconciliation of the most comparable IFRS growth measures to the non-IFRS growth measures for the current period.

Earnings Call and Webcast Information

SOPHiA GENETICS will host a conference call and live webcast to discuss the first quarter 2025 results on Tuesday, May 6, 2025, at 8:00 a.m. (08:00) Eastern Time / 2:00 p.m. (14:00) Central European Time. The call will be webcast live on the SOPHiA GENETICS Investor Relations website, ir.sophiagenetics.com. Additionally, an audio replay of the conference call will be available on the SOPHiA GENETICS website after its completion.

About SOPHiA GENETICS

SOPHiA GENETICS (Nasdaq: SOPH) is a cloud-native healthcare technology company on a mission to expand access to data-driven medicine by using AI to deliver world-class care to patients with cancer and rare disorders across the globe. It is the creator of SOPHiA DDM(TM), a platform that analyzes complex genomic and multimodal data and generates real-time, actionable insights for a broad global network of hospital, laboratory, and biopharma institutions. For more information, visit SOPHiAGENETICS.COM and connect with us on LinkedIn.

Forward-Looking Statements

This press release contains statements that constitute forward-looking statements. All statements other than statements of historical facts contained in this press release, including statements regarding SOPHiA GENETICS future results of operations and financial position, business strategy, products and technology, partnerships and collaborations, as well as plans and objectives of management for future operations, are forward-looking statements. Forward-looking statements are based on SOPHiA GENETICS' management's beliefs and assumptions and on information currently available to the company's management. Such statements are subject to risks and uncertainties, and actual results may differ materially from those expressed or implied in the forward-looking statements due to various factors, including those described in the company's filings with the U.S. Securities and Exchange Commission. No assurance can be given that such future results will be achieved. Such forward-looking statements contained in this press release speak only as of its date. We expressly disclaim any obligation or undertaking to update these forward-looking statements contained in this press release to reflect any change in the company's expectations or any change in events, conditions, or circumstances on which such statements are based, unless required to do so by applicable law. No representations or warranties (expressed or implied) are made about the accuracy of any such forward-looking statements.

 
                            SOPHiA GENETICS SA 
             Interim Condensed Consolidated Statements of Loss 
             (Amounts in USD thousands, except per share data) 
                                (Unaudited) 
 
                                Three months ended March 31, 
                  -------------------------------------------------------- 
                             2025                         2024 
                  ---------------------------  --------------------------- 
Revenue             $                  17,779    $                  15,779 
Cost of revenue                       (5,571)                      (5,374) 
                  ---------------------------  --------------------------- 
Gross profit                           12,208                       10,405 
                  ---------------------------  --------------------------- 
Research and 
 development 
 costs                                (9,118)                      (9,391) 
Selling and 
 marketing 
 costs                                (7,534)                      (6,951) 
General and 
 administrative 
 costs                               (11,600)                     (12,825) 
Other operating 
 income, net                                8                            6 
                  ---------------------------  --------------------------- 
Operating loss                       (16,036)                     (18,756) 
                  ---------------------------  --------------------------- 
Interest income                           450                          901 
Interest expense                        (659)                        (143) 
Fair value 
adjustments on 
warrant 
obligations                              (38)                           -- 
Foreign exchange 
 (losses) gains, 
 net                                    (599)                        4,610 
                  ---------------------------  --------------------------- 
Loss before 
 income taxes                        (16,882)                     (13,388) 
                  ---------------------------  --------------------------- 
Income tax 
 expense                                (503)                        (316) 
                  ---------------------------  --------------------------- 
Loss for the 
 period                              (17,385)                     (13,704) 
                  ---------------------------  --------------------------- 
Attributable to 
 the owners of 
 the parent                          (17,385)                     (13,704) 
                  ---------------------------  --------------------------- 
 
Basic and 
 diluted loss 
 per share        $                    (0.26)  $                    (0.21) 
                  ===========================  =========================== 
 
 
                            SOPHiA GENETICS SA 
      Interim Condensed Consolidated Statements of Comprehensive Loss 
                         (Amounts in USD thousands) 
                                (Unaudited) 
 
                                 Three months ended March 31, 
                    ------------------------------------------------------- 
                               2025                        2024 
                    --------------------------  --------------------------- 
Loss for the 
 period             $                 (17,385)   $                 (13,704) 
Other 
comprehensive 
(loss) income: 
   Items that may 
   be 
   reclassified 
   to statement 
   of loss 
   Currency 
    translation 
    adjustments                          2,586                      (9,393) 
                    --------------------------  --------------------------- 
Total items that 
 may be 
 reclassified to 
 statement of 
 loss                                    2,586                      (9,393) 
   Items that 
   will not be 
   reclassified 
   to statement 
   of loss (net 
   of tax) 
   Remeasurement 
    of defined 
    benefit plans                           47                         (15) 
                    --------------------------  --------------------------- 
Total items that 
 will not be 
 reclassified to 
 statement of 
 loss                                       47                         (15) 
Other 
 comprehensive 
 (loss) income for 
 the period         $                    2,633  $                   (9,408) 
                    ==========================  =========================== 
Total 
 comprehensive 
 loss for the 
 period             $                 (14,752)   $                 (23,112) 
                    ==========================  =========================== 
Attributable to 
 owners of the 
 parent             $                 (14,752)   $                 (23,112) 
                    ==========================  =========================== 
 
 
                            SOPHiA GENETICS SA 
               Interim Condensed Consolidated Balance Sheets 
                        (Amounts in USD thousands) 
                                (Unaudited) 
 
                          March 31, 2025            December 31, 2024 
                    --------------------------  -------------------------- 
Assets 
Current assets 
 Cash and cash 
  equivalents        $                  68,528   $                  80,226 
 Accounts 
  receivable                            10,695                       7,436 
 Inventory                               5,050                       5,868 
 Prepaids and 
  other current 
  assets                                 5,778                       5,875 
                    --------------------------  -------------------------- 
Total current 
 assets                                 90,051                      99,405 
                    --------------------------  -------------------------- 
Non-current 
assets 
 Property and 
  equipment                              4,986                       5,209 
 Intangible assets                      29,994                      28,998 
 Right-of-use 
  assets                                14,028                      14,168 
 Deferred tax 
  assets                                 1,777                       1,767 
 Other non-current 
  assets                                 5,883                       5,762 
                    --------------------------  -------------------------- 
Total non-current 
 assets                                 56,668                      55,904 
                    --------------------------  -------------------------- 
Total assets          $                146,719    $                155,309 
                    ==========================  ========================== 
Liabilities and 
equity 
Current 
liabilities 
 Accounts payable   $                    4,606  $                    5,220 
 Accrued expenses                       11,730                      13,217 
 Deferred contract 
  revenue                                9,838                       5,732 
 Lease 
  liabilities, 
  current portion                        2,288                       2,190 
 Warrant 
  obligations                              482                         444 
Total current 
 liabilities                            28,944                      26,803 
                    --------------------------  -------------------------- 
Non-current 
liabilities 
 Borrowings                             13,317                      13,237 
 Lease 
  liabilities, net 
  of current 
  portion                               14,525                      14,603 
 Defined benefit 
  pension 
  liabilities                            3,983                       3,839 
 Other non-current 
  liabilities                              337                         337 
                    --------------------------  -------------------------- 
Total non-current 
 liabilities                            32,162                      32,016 
                    --------------------------  -------------------------- 
Total liabilities                       61,106                      58,819 
                    --------------------------  -------------------------- 
Equity 
 Share capital                           4,188                       4,188 
 Share premium                         472,283                     472,244 
 Treasury shares                         (694)                       (702) 
 Other reserves                         67,498                      61,037 
 Accumulated 
  deficit                            (457,662)                   (440,277) 
                    --------------------------  -------------------------- 
Total equity                            85,613                      96,490 
                    --------------------------  -------------------------- 
Total liabilities 
 and equity           $                146,719    $                155,309 
                    ==========================  ========================== 
 
 
                            SOPHiA GENETICS SA 
          Interim Condensed Consolidated Statements of Cash Flows 
                        (Amounts in USD thousands) 
                                (Unaudited) 
 
                                 Three months ended March 31, 
                    ------------------------------------------------------ 
                               2025                        2024 
                    --------------------------  -------------------------- 
                                                      (As Recast)(1) 
Operating 
activities 
Loss before tax     $                 (16,882)  $                 (13,388) 
Adjustments for 
non-monetary 
items 
Depreciation                               985                       1,158 
Amortization                             1,312                         901 
Finance expense 
 (income), net                             925                     (5,046) 
Fair value 
adjustments on 
warrant 
obligations                                 38                          -- 
Expected credit 
 loss allowance                           (20)                        (48) 
Share-based 
 compensation                            3,835                       3,714 
Movements in 
 provisions and 
 pensions                                   57                       (135) 
Research tax 
 credit                                  (172)                       (104) 
Working capital 
changes 
(Increase) 
 decrease in 
 accounts 
 receivable                            (2,961)                       2,168 
Decrease 
 (increase) in 
 prepaids and 
 other assets                              393                       (182) 
Decrease in 
 inventory                                 972                         376 
Increase 
 (decrease) in 
 accounts 
 payables, accrued 
 expenses, 
 deferred contract 
 revenue, and 
 other 
 liabilities                               813                     (4,058) 
                    --------------------------  -------------------------- 
Cash used in 
 operating 
 activities                           (10,705)                    (14,644) 
                    --------------------------  -------------------------- 
Income tax paid                           (45)                         (1) 
                    --------------------------  -------------------------- 
Net cash flows 
 used in operating 
 activities                           (10,750)                    (14,645) 
                    --------------------------  -------------------------- 
Investing 
activities 
Purchase of 
 property and 
 equipment                                  --                        (99) 
Acquisition of 
 intangible 
 assets                                   (46)                        (50) 
Capitalized 
 development 
 costs                                 (1,445)                     (1,809) 
Interest received                          452                         953 
                    --------------------------  -------------------------- 
Net cash flow used 
 in investing 
 activities                            (1,039)                     (1,005) 
                                                -------------------------- 
Financing 
activities 
Proceeds from 
 exercise of share 
 options                                    40                         188 
Interest paid                            (567)                       (147) 
Capitalized 
 borrowing 
 transaction 
 costs                                      --                        (49) 
Payments of 
 principal portion 
 of lease 
 liabilities                             (463)                       (735) 
                    --------------------------  -------------------------- 
Net cash flow used 
 in financing 
 activities                              (990)                       (743) 
                    --------------------------  -------------------------- 
Decrease in cash 
 and cash 
 equivalents                          (12,779)                    (16,393) 
                    --------------------------  -------------------------- 
Effect of exchange 
 differences on 
 cash balances                           1,081                     (3,123) 
Cash and cash 
 equivalents at 
 beginning of the 
 year                                   80,226                     123,251 
                    --------------------------  -------------------------- 
Cash and cash 
 equivalents at 
 end of the 
 period              $                  68,528    $                103,735 
                    ==========================  ========================== 
 
 
(1) Refer to "Note 1--Change in accounting policies--Statement of Cash Flows - 
Interest Classification" for details on change in accounting policy of exhibit 
99.1 within of the Form 6-K filed on May 6,2025 . 
 
 
                            SOPHiA GENETICS SA 
       Reconciliation of IFRS Net Loss to EBITDA and Adjusted EBITDA 
                        (Amounts in USD thousands) 
                                (Unaudited) 
 
                                Three months ended March 31, 
                   ------------------------------------------------------- 
                              2025                         2024 
Loss for the 
 period             $                 (17,385)  $                 (13,704) 
Exclude the 
impact of: 
Depreciation       $                       985  $                    1,158 
Amortization                             1,312                         901 
Interest income                          $(450.UK)$                       (901) 
Interest expense                           659                         143 
Fair value 
adjustments on 
warrant 
obligations                                 38                          -- 
Foreign exchange 
 gains (losses), 
 net                                       599                     (4,610) 
Income tax 
 expense                                   503                         316 
                   ---------------------------  -------------------------- 
EBITDA              $                 (13,739)  $                 (16,697) 
Adjustments to 
EBITDA: 
Share-based 
 compensation 
 expense(1)                              3,835                       3,714 
Non-cash pension 
 expense(2)                                 86                          77 
Adjusted EBITDA    $                   (9,818)  $                 (12,906) 
 
 
  SOPHiA GENETICS SA Reconciliation of IFRS Net Loss to EBITDA and Adjusted 
   EBITDA for the fiscal year 2024 (Amounts in USD thousands) (Unaudited) 
 
                                         Year ended 
                ------------------------------------------------------------- 
                                      December 31, 2024 
Loss for the 
 period          $                                                   (62,493) 
Exclude the 
impact of: 
Depreciation    $                                                       4,575 
Amortization                                                            4,021 
Interest 
 income                                                               (3,362) 
Interest 
 expense                                                                1,913 
Fair value 
 adjustments 
 on warrant 
 obligations                                                            (370) 
Foreign 
 exchange 
 losses, net                                                          (3,479) 
Income tax 
 expense                                                                1,223 
                ------------------------------------------------------------- 
EBITDA           $                                                   (57,972) 
Adjustments 
to EBITDA: 
Share-based 
 compensation 
 expense(1)                                                            16,488 
Non-cash 
 pension 
 expense(2)                                                             1,306 
Adjusted 
 EBITDA          $                                                   (40,178) 
 
 
  SOPHiA GENETICS SA Reconciliation of IFRS Revenue Growth to Constant 
    Currency Revenue Growth (Amounts in USD thousands, except for %) 
                              (Unaudited) 
 
                                        Three months ended March 31, 
                                    ------------------------------------ 
                                        2025           2024       Growth 
                                    -------------  -------------  ------ 
IFRS revenue                        $      17,779  $      15,779    13 % 
 Current period constant currency 
 impact                                       418             -- 
                                    -------------  -------------  ------ 
Constant currency revenue           $      18,197  $      15,779    15 % 
 
 
                            SOPHiA GENETICS SA 
  Reconciliation of IFRS to Adjusted Gross Profit and Gross Profit Margin 
              (Amounts in USD thousands, except percentages) 
                                (Unaudited) 
 
                                     Three months ended March 31, 
                            ---------------------------------------------- 
                                     2025                    2024 
                            ----------------------  ---------------------- 
Revenue                     $               17,779  $               15,779 
 Cost of revenue                           (5,571)                 (5,374) 
                            ----------------------  ---------------------- 
Gross profit                $               12,208  $               10,405 
 Amortization of 
  capitalized research and 
  development expenses(3)                    1,241                     727 
Adjusted gross profit       $               13,449  $               11,132 
                            ======================  ====================== 
 
Gross profit margin                         68.7 %                  65.9 % 
 Amortization of 
  capitalized research and 
  development expenses(3)                    7.0 %                   4.6 % 
Adjusted gross profit 
 margin                                     75.7 %                  70.5 % 
 
 
                            SOPHiA GENETICS SA 
     Reconciliation of IFRS to Adjusted Operating Loss for the Period 
                        (Amounts in USD thousands) 
                                (Unaudited) 
 
                                 Three months ended March 31, 
                    ------------------------------------------------------ 
                               2025                        2024 
                    --------------------------  -------------------------- 
Operating loss      $                 (16,036)  $                 (18,756) 
 Amortization of 
  capitalized 
  research & 
  development 
  expenses(3)                            1,241                         727 
 Amortization of 
  intangible 
  assets(4)                                 71                         174 
 Share-based 
  compensation 
  expense(1)                             3,835                       3,714 
 Non-cash pension 
  expense(2)                                86                          77 
Adjusted operating 
 loss               $                 (10,803)  $                 (14,064) 
                    ==========================  ========================== 
 
 
  Notes to the Reconciliation of IFRS to Adjusted Financial Measures Tables 
 
(1)  Share-based compensation expense represents the cost of equity awards 
     issued to our directors, officers, and employees. The fair value of 
     awards is computed at the time the award is granted and is recognized 
     over the vesting period of the award by a charge to the income statement 
     and a corresponding increase in other reserves within equity. These 
     expenses do not have a cash impact but remain a recurring expense for our 
     business and represent an important part of our overall compensation 
     strategy. 
(2)  Non-cash pension expense consists of the amount recognized in excess of 
     actual contributions made to our defined pension plans to match actuarial 
     expenses calculated for IFRS purposes. The difference represents a 
     non-cash expense but remains a recurring expense for our business as we 
     continue to make contributions to our plans for the foreseeable future. 
(3)  Amortization of capitalized research and development expenses consists of 
     software development costs amortized using the straight-line method over 
     an estimated life of five years. These expenses do not have a cash impact 
     but remain a recurring expense generated over the course of our research 
     and development initiatives. 
(4)  Amortization of intangible assets consists of costs related to intangible 
     assets amortized over the course of their useful lives. These expenses do 
     not have a cash impact, but we could continue to generate such expenses 
     through future capital investments. 
 

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May 06, 2025 06:45 ET (10:45 GMT)

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