超21億美元！國產BCMA/CD19雙靶CAR-T授權出海

生物製品圈

2025/07/22

7月22日，科弈藥業宣佈，與美國生物醫藥企業ERIGEN LLC達成戰略合作，雙方簽署了關於科弈藥業自主研發的全球首個並聯增強型雙靶向CAR-T細胞治療產品KQ-2003（靶向BCMA/CD19）的獨家海外授權許可協議。KQ-2003是科弈藥業基於增強型雙靶CAR-T平台開發的創新療法，通過並聯結構設計和信號域優化，顯著提升CAR-T細胞的持久性與抗腫瘤活性，同時降低傳統CAR-T的復發風險。根據...

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Domestic BCMA/CD19 dual-target CAR-T authorized to go overseas","themeId":null,"isJumpTheme":false,"ttsUrl":null,"symbols_score_info":{"CAR":1,"AZN":0.9},"content_text":"7月22日，科弈藥業宣佈，與美國生物醫藥企業ERIGEN LLC達成戰略合作，雙方簽署了關於科弈藥業自主研發的全球首個並聯增強型雙靶向CAR-T細胞治療產品KQ-2003（靶向BCMA/CD19）的獨家海外授權許可協議。KQ-2003是科弈藥業基於增強型雙靶CAR-T平台開發的創新療法，通過並聯結構設計和信號域優化，顯著提升CAR-T細胞的持久性與抗腫瘤活性，同時降低傳統CAR-T的復發風險。根據醫藥魔方數據庫，聚焦BCMA/CD19雙靶CAR-T賽道，科弈藥業的KQ-2003目前在全球排名第3，此外阿斯利康旗下的亙喜生物也佈局了同類產品。此次合作涵蓋大中華區以外（不含印度、土耳其及俄羅斯）的全球權益，ERIGEN將獲得該產品在相關區域的獨家開發、註冊和商業化權利。此外，協議還授予ERIGEN使用KQ-2003關鍵專利結構與序列，用於開發「通用型CAR-T細胞療法」的權利。根據合作條款，科弈藥業將獲得1500萬美元近期開發里程碑付款，並有資格獲得總金額最高達13.2億美元的研發、註冊及商業化階段里程碑付款，此外，科弈藥業還將基於KQ-2003在授權區域的淨銷售額，獲得最高8億美元的銷售分成。根據協議安排，科弈藥業保留該通用型產品在大中華區的完整權益，為後續聯合開發及區域商業化奠定基礎。識別微信二維碼，添加生物製品圈小編，符合條件者即可加入生物製品微信羣！請註明：姓名+研究方向！版權聲明本公眾號所有轉載文章系出於傳遞更多信息之目的，且明確註明來源和作者，不希望被轉載的媒體或個人可與我們聯繫(cbplib@163.com)，我們將立即進行刪除處理。所有文章僅代表作者觀不本站。","kind":"news","is_publish_news":true,"is_publish_highlight":false,"is_publish_live":false,"is_publish_wemedia":null,"editions":null,"column":"","sentiment":"1","news_tag":"","news_rank":0,"symbols":[],"gpt_button":1,"need_auth":false,"code":"91000000","status":"200"}}}