Akeso Inc. Announces Launch of Phase III Clinical Trial for Ivonescimab in Treatment of IO-Resistant NSCLC

Reuters

2025/07/31

Akeso Inc. Announces Launch of Phase III Clinical Trial for Ivonescimab in Treatment of IO-Resistant NSCLC

Akeso Inc. has announced the initiation of a Phase III clinical trial involving ivonescimab, a PD-1/VEGF bispecific antibody, in combination with docetaxel for the treatment of locally advanced or metastatic non-small cell lung cancer (NSCLC) that has progressed following PD-1/L1 inhibitors and platinum-based chemotherapy. This pivotal study, AK112-305/HARMONi-8A, recently dosed its first patient. Ivonescimab is notable for being the only bispecific immunotherapy antibody currently in Phase III registration trials for immunotherapy-resistant lung cancer. The trial aims to provide a novel treatment option for patients with IO-resistant NSCLC, leveraging the synergistic effects of targeting both PD-1 and VEGF pathways to reactivate anti-tumor immune responses. The results of this ongoing study have not yet been presented.

Disclaimer: This news brief was created by Public Technologies (PUBT) using generative artificial intelligence. While PUBT strives to provide accurate and timely information, this AI-generated content is for informational purposes only and should not be interpreted as financial, investment, or legal advice. Akeso Inc. published the original content used to generate this news brief via PR Newswire (Ref. ID: CN41516) on July 31, 2025, and is solely responsible for the information contained therein.

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Announces Launch of Phase III Clinical Trial for Ivonescimab in Treatment of IO-Resistant NSCLC\n</h2>\n<h4 class=\"meta\">\n<a class=\"head\" href=\"https://laohu8.com/wemedia/1032215980\">\n\n<div class=\"h-thumb\" style=\"background-image:url(https://community-static.tradeup.com/news/4567337cbdf294b657b1fa87c5488b48);background-size:cover;\"></div>\n\n<div class=\"h-content\">\n<p class=\"h-name\">Reuters </p>\n<p class=\"h-time smaller\">2025-07-31 09:47</p>\n</div>\n</a>\n</h4>\n</header>\n<article>\n<html xmlns=\"http://www.w3.org/1999/xhtml\" xmlns:newsg2=\"http://iptc.org/std/nar/2006-10-01/\" xmlns:xhtml=\"http://www.w3.org/1999/xhtml\"><head><title>\n      Akeso Inc. Announces Launch of Phase III Clinical Trial for Ivonescimab in Treatment of IO-Resistant NSCLC\n    </title></head><body><div xmlns:xsd=\"http://www.w3.org/2001/XMLSchema\" xmlns:xsi=\"http://www.w3.org/2001/XMLSchema-instance\">\n<p>\n        Akeso Inc. has announced the initiation of a Phase III clinical trial involving ivonescimab, a PD-1/VEGF bispecific antibody, in combination with docetaxel for the treatment of locally advanced or metastatic non-small cell lung cancer (NSCLC) that has progressed following PD-1/L1 inhibitors and platinum-based chemotherapy. This pivotal study, AK112-305/HARMONi-8A, recently dosed its first patient. Ivonescimab is notable for being the only bispecific immunotherapy antibody currently in Phase III registration trials for immunotherapy-resistant lung cancer. 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ID: CN41516) on July 31, 2025, and is solely responsible for the information contained therein.</span></em>\n</div></body></html>\n</article>\n</div>\n</body>\n</html>\n","isBrief":false,"type":0,"news_type":1,"symbol":"IE00BPRC5H50.USD","symbol_name":"NEUBERGER BERMAN CHINA EQUITY \"A\" (USD) INC","start_time":0,"source_url":"https://api.refinitiv.com/data/news/v1/stories/urn:newsml:reuters.com:20250731:nNDL75mxhk:1","article_id":"2555607999","we_media_id":"1032215980","thumbnails":[],"rights":null,"url":"https://stock-news.laohu8.com/highlight/detail?id=2555607999","pubTimestamp":1753926439,"columns":[],"sourceInfo":null,"weMediaInfo":{"media_name":"Reuters","introduction":"Reuters.com brings you the latest news from around the world, covering breaking news in markets, business, politics, entertainment and technology","home_visible":1,"id":"1032215980","head_image":"https://community-static.tradeup.com/news/4567337cbdf294b657b1fa87c5488b48"},"summary":"Akeso Inc. has announced the initiation of a Phase III clinical trial involving ivonescimab, a PD-1/VEGF bispecific antibody, in combination with docetaxel for the treatment of locally advanced or metastatic non-small cell lung cancer  that has progressed following PD-1/L1 inhibitors and platinum-based chemotherapy. 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Announces Launch of Phase III Clinical Trial for Ivonescimab in Treatment of IO-Resistant NSCLC\n    \n\n        Akeso Inc. has announced the initiation of a Phase III clinical trial involving ivonescimab, a PD-1/VEGF bispecific antibody, in combination with docetaxel for the treatment of locally advanced or metastatic non-small cell lung cancer (NSCLC) that has progressed following PD-1/L1 inhibitors and platinum-based chemotherapy. This pivotal study, AK112-305/HARMONi-8A, recently dosed its first patient. Ivonescimab is notable for being the only bispecific immunotherapy antibody currently in Phase III registration trials for immunotherapy-resistant lung cancer. The trial aims to provide a novel treatment option for patients with IO-resistant NSCLC, leveraging the synergistic effects of targeting both PD-1 and VEGF pathways to reactivate anti-tumor immune responses. The results of this ongoing study have not yet been presented.\n      \n\nDisclaimer: This news brief was created by Public Technologies (PUBT) using generative artificial intelligence. While PUBT strives to provide accurate and timely information, this AI-generated content is for informational purposes only and should not be interpreted as financial, investment, or legal advice. Akeso Inc. published the original content used to generate this news brief via PR Newswire (Ref. ID: CN41516) on July 31, 2025, and is solely responsible for the information contained therein.","kind":"highlight","is_publish_news":true,"is_publish_highlight":false,"is_publish_live":false,"is_publish_wemedia":null,"editions":null,"column":"","sentiment":"1","news_tag":"productRelease","news_rank":0,"symbols":[],"gpt_button":0,"need_auth":true,"code":"91000000","status":"200"}}}