The world's economy is constantly evolving, but some shifts are so large and long-lasting that they shape industries for decades.

These are called megatrends — powerful structural changes that create long-term growth opportunities for businesses and investors alike.

The good news for Australian investors is that you don't need to look overseas to tap into them. The ASX offers access to a number of ETFs that are positioned to benefit from these trends.

Here are three global megatrends you can invest in right now, without leaving the local market.

Artificial intelligence and automation

From ChatGPT to self-driving cars, artificial intelligence (AI) is rapidly moving from science fiction to everyday reality. Automation, powered by AI, is also transforming industries from logistics to healthcare.

One ASX ETF that targets this trend is the Betashares Global Robotics and Artificial Intelligence ETF (ASX: RBTZ). It provides exposure to companies developing cutting-edge AI applications, robotics systems, and automation technologies. Holdings include NVIDIA (NASDAQ: NVDA), a leader in AI chips, and Intuitive Surgical (NASDAQ: ISRG), which makes robotic surgery systems.

With AI adoption expected to accelerate for decades, this megatrend offers investors a rare blend of innovation and scale.

The rise of Asia's middle class

Asia is home to a fast-growing consumer base, with hundreds of millions of people moving into the middle class. This is boosting demand for everything from technology and financial services to travel and premium goods.

Investors can tap into this trend through the Betashares Asia Technology Tigers ETF (ASX: ASIA), which includes giants like TSMC (NYSE: TSM), Meituan (SEHK: 3690), and PDD Holdings (NASDAQ: PDD). These companies are benefiting from rapid digital adoption and increasing consumer spending in the region.

With Asia's economic growth expected to outpace many developed markets, this megatrend could be a powerful long-term driver of returns.

Global healthcare innovation

An ageing population, rising healthcare spending, and advances in medical technology are fuelling a boom in healthcare innovation. From biotechnology to medical devices and digital health, this trend is only getting stronger.

Australian investors can gain access via the iShares Global Healthcare ETF (ASX: IXJ). Its holdings include Johnson & Johnson (NYSE: JNJ), AbbVie Inc (NYSE: ABBV), and locally listed ResMed Inc (ASX: RMD). These are companies at the forefront of treating chronic diseases, improving patient outcomes, and delivering cutting-edge medical products.

Healthcare demand tends to be resilient across economic cycles, making this megatrend an attractive option for defensive growth.