Oct 3 (Reuters) - Wall Street's main indexes looked set to climb on Friday as optimism about an imminent interest-rate cut by the Federal Reserve boosted sentiment ahead of the final trading session of a week that saw volatility due to the U.S. .N

At 10:28 EDT, the Dow Jones Industrial Average .DJI was up 0.79% at 46,889.01.The S&P 500 .SPX was up 0.32% at 6,736.59, and the Nasdaq Composite .IXIC was up 0.03% at 22,851.38.

The top three S&P 500 .PG.INX percentage gainers:

** Humana Inc HUM.N, up 5.7%

** Align Technology Inc ALGN.OQ, up 4.5%

** Centene Corp CNC.N, up 4.4%

The top three S&P 500 .PL.INX percentage losers:

** Las Vegas Sands Corp LVS.N, down 5.6%

** Wynn Resorts Ltd WYNN.OQ, down 5.5%

** Palantir Technologies Inc PLTR.OQ, down 4.4%

The top three NYSE .PG.N percentage gainers:

** Alto Neuroscience Inc ANRO.N, up 58.0%

** Lithium Americas Corp LAC.N, up 26.7%

** SES AI Corp SES.N, up 16.0%

The top three NYSE .PL.N percentage losers:

** Lufax Holding Ltd LU.N, down 10.3%

** BGSF Inc BGSF.N, down 7.4%

** Roblox Corp RBLX.N, down 6.8%

The top three Nasdaq .PG.O percentage gainers:

** Epsium Enterprise Ltd EPSM.OQ, up 86.3%

** Actelis Networks Inc ASNS.OQ, up 75.9%

** Anbio Biotechnology NNNN.OQ, up 49.1%

The top three Nasdaq .PL.O percentage losers:

** American Rebel Holdings Inc AREB.OQ, down 27.6%

** Masonglory Ltd MSGY.OQ, down 16.2%

** Aspire Biopharma Holdings Inc ASBP.OQ, down 14.3%

** USA Rare Earth USAR.O:

BUZZ- Rises after report firm in talks with White House nL3N3VK0GB

** Applied Materials AMAT.O:

BUZZ- Falls on $600 million revenue hit from China export curbs nL3N3VK0GF

** Duke Energy DUK.N:

BUZZ- Scotiabank raises PT on Duke Energy; upgrades to "sector outperform" nL3N3VK0JA

** Instacart CART.O:

BUZZ- Slips after Piper Sandler downgrades on rising competition nL6N3VK0FL

** CSW Industrials CSW.N:

BUZZ- J.P.Morgan cuts CSW Industrials PT on macro risks

nL3N3VK0KA

** Shift4Payments FOUR.N:

BUZZ- Morgan Stanley cuts Shift4Payments' PT on low earnings optimism nL6N3VK0FX

** Rocket Pharmaceuticals RCKT.O:

BUZZ- Falls after pulling US application for blood disorder gene therapy nL6N3VK0GZ

** Occidental Petroleum OXY.N:

BUZZ- Gains as Mizuho upgrades rating to 'Outperform' on balance sheet boost, shale strength nL3N3VK0MR

** Ovid Therapeutics OVID.O:

BUZZ- Jumps after seizure treatment shows promise in trial nL3N3VK0MH

** Alto Neuroscience ANRO.N:

BUZZ- Climbs on FDA's 'fast track' tag for schizophrenia drug nL3N3VK0N5 ** Alaska Air ALK.N:

BUZZ- TD Cowen cuts Alaska Air PT amid cost pressure, IT outage impact nL3N3VK0NO

** Alphabet GOOGL.O:

BUZZ- Morgan Stanley lifts Alphabet’s PT on stronger search and cloud growth boosting EPS nL3N3VA0PV

** Apple AAPL.O:

BUZZ- Down after Jefferies downgrades to 'underperform' nL3N3VK0PA

** Tesla TSLA.O:

BUZZ- J.P.Morgan lifts Tesla's PT on upbeat Q3 deliveries; shares rise nL3N3VK0PC

** BHP Group BHP.N:

** Southern Copper Corp SCCO.N:

** Freeport-McMoRan Inc FCX.N:

** Teck Resources Ltd TECK.N:

** Hudbay Minerals Inc BUZZ- Copper miners gain as red metal hits 16-month high

** Starbucks SBUX.O:

BUZZ- TD Cowen cuts Starbucks' PT on softening Gen-Z dynamic

** GME.N:

BUZZ- Falls after mixed shelf offering filing nL6N3VK0IR ** Esperion ESPR.O:

BUZZ- Cimbs after patent win over Dr. Reddy’s cholesterol drugs nL3N3VK0R3

** Victoria's Secret VSCO.N:

BUZZ- Up after Jefferies raises PT to Street high ahead of 2025 Fashion Show nL6N3VK0IH

(Compiled by Sahil Pandey in Bengaluru)

((Sahil.Pandey@thomsonreuters.com;))