Autolus Therapeutics Doses First Patient in Phase 1 Trial of Obe-Cel for Progressive Multiple Sclerosis

Reuters

2025/10/20

Autolus <a href="https://laohu8.com/S/LENZ">Therapeutics</a> Doses First Patient in Phase 1 Trial of Obe-Cel for Progressive Multiple Sclerosis

Autolus Therapeutics plc has announced the dosing of the first patient in its Phase 1 BOBCAT trial evaluating obecabtagene autoleucel (obe-cel) in patients with progressive multiple sclerosis (PMS). The study, conducted at University College London Hospitals NHS Foundation Trust, will enroll up to 18 adult patients to assess the safety, tolerability, and preliminary efficacy of obe-cel in refractory progressive forms of multiple sclerosis. The primary endpoint is safety and tolerability, with additional data to be collected on efficacy measures. Preliminary results from the trial have not yet been presented.

Disclaimer: This news brief was created by Public Technologies (PUBT) using generative artificial intelligence. While PUBT strives to provide accurate and timely information, this AI-generated content is for informational purposes only and should not be interpreted as financial, investment, or legal advice. Autolus Therapeutics plc published the original content used to generate this news brief via GlobeNewswire (Ref. ID: GNW9547732-en) on October 20, 2025, and is solely responsible for the information contained therein.

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The study, conducted at University College London Hospitals NHS Foundation Trust, will enroll up to 18 adult patients to assess the safety, tolerability, and preliminary efficacy of obe-cel in refractory progressive forms of multiple sclerosis. The primary endpoint is safety and tolerability, with additional data to be collected on efficacy measures. Preliminary results from the trial have not yet been presented.\n      </p>\n</div><div xmlns:xsd=\"http://www.w3.org/2001/XMLSchema\" xmlns:xsi=\"http://www.w3.org/2001/XMLSchema-instance\">\n<em>Disclaimer: <span>This news brief was created by Public Technologies (PUBT) using generative artificial intelligence. While PUBT strives to provide accurate and timely information, this AI-generated content is for informational purposes only and should not be interpreted as financial, investment, or legal advice. Autolus Therapeutics plc published the original content used to generate this news brief via GlobeNewswire (Ref. ID: GNW9547732-en) on October 20, 2025, and is solely responsible for the information contained therein.</span></em>\n</div></body></html>\n</article>\n</div>\n</body>\n</html>\n","isBrief":false,"type":0,"news_type":1,"symbol":"LU2210150020.SGD","symbol_name":"Natixis Thematics Subscription Economy R/A SGD","start_time":0,"source_url":"https://api.refinitiv.com/data/news/v1/stories/urn:newsml:reuters.com:20251020:nNDL19R4Ch:1","article_id":"2576853149","we_media_id":"1032215980","thumbnails":[],"rights":null,"url":"https://stock-news.laohu8.com/highlight/detail?id=2576853149","pubTimestamp":1760958024,"columns":[],"sourceInfo":null,"weMediaInfo":{"media_name":"Reuters","introduction":"Reuters.com brings you the latest news from around the world, covering breaking news in markets, business, politics, entertainment and technology","home_visible":1,"id":"1032215980","head_image":"https://community-static.tradeup.com/news/4567337cbdf294b657b1fa87c5488b48"},"summary":"Autolus Therapeutics plc has announced the dosing of the first patient in its Phase 1 BOBCAT trial evaluating obecabtagene autoleucel  in patients with progressive multiple sclerosis . 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The study, conducted at University College London Hospitals NHS Foundation Trust, will enroll up to 18 adult patients to assess the safety, tolerability, and preliminary efficacy of obe-cel in refractory progressive forms of multiple sclerosis. The primary endpoint is safety and tolerability, with additional data to be collected on efficacy measures. Preliminary results from the trial have not yet been presented.\n      \n\nDisclaimer: This news brief was created by Public Technologies (PUBT) using generative artificial intelligence. While PUBT strives to provide accurate and timely information, this AI-generated content is for informational purposes only and should not be interpreted as financial, investment, or legal advice. Autolus Therapeutics plc published the original content used to generate this news brief via GlobeNewswire (Ref. 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