Monte Rosa Therapeutics Inc. announced that it will present new preclinical data on MRT-6160, a VAV1-directed molecular glue degrader, at ACR Convergence 2025, held October 24-29 in Chicago, IL. The data will be presented in a poster session on October 26 at 10:30 am CDT. Preclinical results demonstrate that MRT-6160 inhibited disease pathology, including proteinuria, lymphadenopathy, skin lesion formation, autoantibody production, and organomegaly, in a spontaneous autoimmune disease mouse model. The findings support the potential of MRT-6160 to address multiple rheumatic autoimmune and inflammatory diseases, such as Sjögren's disease, systemic lupus erythematosus, and rheumatoid arthritis. According to the company, MRT-6160 attenuated T and B cell effector functions and reduced disease progression in preclinical studies. Further development toward Phase 2 clinical studies is underway.