4D Molecular Therapeutics Inc. (4DMT) announced an exclusive license agreement with Otsuka Pharmaceutical Co., Ltd. for the development and commercialization of 4D-150 in the Asia-Pacific region, including Japan. Under the terms of the agreement, 4DMT will receive an upfront cash payment of $85 million and is expected to receive at least $50 million in cost sharing from Otsuka over the next three years to support global development activities. The agreement also includes up to $336 million in potential regulatory and commercial milestone payments, along with tiered double-digit royalties based on net sales in Otsuka's territories. 4DMT retains full development and commercialization rights for 4D-150 outside the APAC region, including the U.S., Latin America, and Europe. Proceeds and cost sharing from this agreement are expected to support a global Phase 3 clinical trial in diabetic macular edema (DME) and pre-commercial activities.