Arvinas Reports Positive Phase 1 Data and Advances Pipeline in Q3 2025 Update
Arvinas Inc. announced its third quarter 2025 financial results and provided a corporate update. The company reported positive data from Phase 1 clinical trials of ARV-102 in both healthy volunteers and patients with Parkinson's disease. Preclinical data from ARV-806 showed robust and differentiated activity in models of KRAS G12D-mutated cancer. Additionally, preclinical data from ARV-027 demonstrated significant degradation of polyQ-AR in muscle, supporting further evaluation as a potential disease-modifying therapy in spinal bulbar muscular atrophy (SBMA). Arvinas also announced an agreement with Pfizer to jointly select a third party for the commercialization and potential further development of vepdegestrant. The company highlighted these developments as part of its ongoing efforts to advance its PROTAC degrader portfolio.
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