Replimune Group Inc. reported research and development expenses of $57.9 million for the fiscal second quarter ended September 30, 2025, up from $43.4 million for the same period in 2024. The increase was mainly due to higher direct research costs related to the IGNYTE-3 confirmatory study and other study costs, as well as increased personnel-related expenses in preparation for a potential commercial launch of RP1. Cash, cash equivalents, and short-term investments totaled $323.6 million as of September 30, 2025, compared to $483.8 million as of March 31, 2025. The company announced the FDA accepted the BLA resubmission for RP1 for advanced melanoma, with a PDUFA target action date of April 10, 2026. Replimune expects its current cash position to fund operations into late Q4 2026, including potential commercialization of RP1 in skin cancers.