Monopar Therapeutics Inc. reported a net loss of $3.4 million, or $0.48 per share, for the third quarter of 2025, compared to a net loss of $1.3 million, or $0.37 per share, for the same period in 2024. As of September 30, 2025, the company held $143.7 million in cash, cash equivalents, and investments. Recent business developments include FDA clearance of an IND application for MNPR-101-Lu, a Phase 1 trial for advanced or metastatic solid tumors, and preparations to submit a New Drug Application for ALXN1840 for Wilson disease in early 2026. The company also completed a share repurchase of 550,229 shares from Tactic Pharma for $35 million, following a public offering, resulting in net proceeds of approximately $91.9 million before expenses.