BioAge Labs Inc. has announced positive interim results from an ongoing Phase 1 clinical trial of BGE-102, a novel orally available, brain-penetrant NLRP3 inhibitor. The study's initial findings indicate that BGE-102 was well tolerated across single and multiple ascending dose cohorts, with a pharmacokinetic profile supporting once-daily oral dosing. BGE-102 demonstrated strong target engagement, achieving 90-98% suppression of IL-1β at Day 14, and high brain penetration at doses of 60 mg and above. The company is expanding the Phase 1 trial to include multiple ascending dose cohorts in participants with obesity and elevated hsCRP, with data from these cohorts anticipated in the first half of 2026. Full safety and efficacy analyses will follow after database lock and unblinding.