Transcenta Holding Limited has announced updated efficacy data from the phase I/II Transtar102 trial evaluating osemitamab in combination with nivolumab and CAPOX as a first-line treatment for gastric or gastroesophageal junction (G/GEJ) cancer. The findings were presented in a poster session at the ESMO Asia Congress 2025 in Singapore. In a subgroup of 26 patients with high CLDN18.2 expression (≥40%, ≥2+), the median progression-free survival $(PFS)$ was 16.6 months, the objective response rate $(ORR)$ was 68%, and the median duration of response (DoR) was 18 months at a median follow-up of 25.8 months. The results indicated consistent treatment benefit of osemitamab regardless of PD-L1 expression levels.
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