Innovent Biologics Inc. has announced the results of a Phase 1b clinical study evaluating mazdutide, a dual GLP-1 and glucagon receptor agonist, in Chinese adolescents with obesity. The study met its primary endpoint, with participants receiving 4 mg and 6 mg doses of mazdutide achieving BMI reductions of 8.78% and 10.99%, and weight reductions of 7.72 kg and 8.65 kg, respectively, over 12 weeks. These outcomes were significantly greater than those observed in the placebo group. Mazdutide also showed favorable safety and tolerability, with no serious adverse events reported. Improvements were noted in multiple metabolic parameters. Based on these results, Innovent Biologics plans to initiate a Phase 3 registration clinical trial in adolescents with obesity or overweight in the near future.