Kazia Therapeutics Reports Paxalisib Shows Tumor Shrinkage and Immune Reinvigoration in Advanced Breast Cancer Trial

Reuters

2025/12/10

<a href="https://laohu8.com/S/KZA.AU">Kazia Therapeutics</a> Reports Paxalisib Shows Tumor Shrinkage and Immune Reinvigoration in Advanced Breast Cancer Trial

Kazia Therapeutics Limited has announced new clinical and translational findings demonstrating the activity of its brain-penetrant dual PI3K/mTOR inhibitor, paxalisib, across multiple advanced breast cancer populations, including triple-negative breast cancer (TNBC) and HER2-positive metastatic breast cancer. The results were presented at the 2025 San Antonio Breast Cancer Symposium (SABCS). Highlights include a 76% reduction in tumor volume in the first TNBC patient, significant decreases in circulating tumor cell (CTC) clusters, and evidence of immune system reinvigoration. Preliminary ex-vivo data in HER2-positive patients showed similar immune effects and reductions in CTCs. The findings suggest that paxalisib may address metastatic mechanisms not targeted by current therapies.

Disclaimer: This news brief was created by Public Technologies (PUBT) using generative artificial intelligence. While PUBT strives to provide accurate and timely information, this AI-generated content is for informational purposes only and should not be interpreted as financial, investment, or legal advice. Kazia Therapeutics Limited published the original content used to generate this news brief via PR Newswire (Ref. ID: CN43262) on December 10, 2025, and is solely responsible for the information contained therein.

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The results were presented at the 2025 San Antonio Breast Cancer Symposium (SABCS). Highlights include a 76% reduction in tumor volume in the first TNBC patient, significant decreases in circulating tumor cell (CTC) clusters, and evidence of immune system reinvigoration. Preliminary ex-vivo data in HER2-positive patients showed similar immune effects and reductions in CTCs. The findings suggest that paxalisib may address metastatic mechanisms not targeted by current therapies.\n      </p>\n</div><div xmlns:xsd=\"http://www.w3.org/2001/XMLSchema\" xmlns:xsi=\"http://www.w3.org/2001/XMLSchema-instance\">\n<em>Disclaimer: <span>This news brief was created by Public Technologies (PUBT) using generative artificial intelligence. 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The results were presented at the 2025 San Antonio Breast Cancer Symposium (SABCS). Highlights include a 76% reduction in tumor volume in the first TNBC patient, significant decreases in circulating tumor cell (CTC) clusters, and evidence of immune system reinvigoration. Preliminary ex-vivo data in HER2-positive patients showed similar immune effects and reductions in CTCs. The findings suggest that paxalisib may address metastatic mechanisms not targeted by current therapies.\n      </p>\n</div><div xmlns:xsd=\"http://www.w3.org/2001/XMLSchema\" xmlns:xsi=\"http://www.w3.org/2001/XMLSchema-instance\">\n<em>Disclaimer: <span>This news brief was created by Public Technologies (PUBT) using generative artificial intelligence. While PUBT strives to provide accurate and timely information, this AI-generated content is for informational purposes only and should not be interpreted as financial, investment, or legal advice. <a href=\"https://laohu8.com/S/NVGNF\">Kazia Therapeutics Limited</a> published the original content used to generate this news brief via PR Newswire (Ref. ID: CN43262) on December 10, 2025, and is solely responsible for the information contained therein.</span></em>\n</div></body></html>\n</article>\n</div>\n</body>\n</html>\n","isBrief":false,"type":0,"news_type":1,"symbol":"BK4139","symbol_name":"生物科技","start_time":0,"source_url":"https://api.refinitiv.com/data/news/v1/stories/urn:newsml:reuters.com:20251210:nNDL5L8hvJ:1","article_id":"2590837587","we_media_id":"1032215980","thumbnails":[],"rights":null,"url":"https://stock-news.laohu8.com/highlight/detail?id=2590837587","pubTimestamp":1765371654,"columns":[],"sourceInfo":null,"weMediaInfo":{"media_name":"Reuters","introduction":"Reuters.com brings you the latest news from around the world, covering breaking news in markets, business, politics, entertainment and technology","home_visible":1,"id":"1032215980","head_image":"https://community-static.tradeup.com/news/4567337cbdf294b657b1fa87c5488b48"},"summary":"Kazia Therapeutics Limited has announced new clinical and translational findings demonstrating the activity of its brain-penetrant dual PI3K/mTOR inhibitor, paxalisib, across multiple advanced breast cancer populations, including triple-negative breast cancer  and HER2-positive metastatic breast cancer. 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