ProMIS Neurosciences Completes Enrollment for Phase 1b Trial of PMN310 in Alzheimer’s Disease

Reuters

2025/12/18

ProMIS Neurosciences Completes Enrollment for Phase 1b Trial of PMN310 in Alzheimer’s Disease

ProMIS Neurosciences Inc. has announced the completion of patient enrollment for its PRECISE-AD Phase 1b clinical trial of PMN310, a therapeutic antibody candidate for the treatment of Alzheimer's disease. The trial enrolled 144 patients with mild cognitive impairment or early Alzheimer's disease, exceeding the initial target. The study is a randomized, double-blind, placebo-controlled trial designed to assess the safety, tolerability, pharmacokinetics, biomarkers, and clinical effects of PMN310, which targets toxic soluble amyloid-beta oligomers. Interim blinded data from a 6-month analysis are expected in the second quarter of 2026, with final unblinded top-line results anticipated in the fourth quarter of 2026. No treatment-related serious adverse events have been reported so far. Results have not yet been presented.

Disclaimer: This news brief was created by Public Technologies (PUBT) using generative artificial intelligence. While PUBT strives to provide accurate and timely information, this AI-generated content is for informational purposes only and should not be interpreted as financial, investment, or legal advice. ProMIS Neurosciences Inc. published the original content used to generate this news brief via GlobeNewswire (Ref. ID: GNW9604315-en) on December 18, 2025, and is solely responsible for the information contained therein.

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The trial enrolled 144 patients with mild cognitive impairment or early Alzheimer's disease, exceeding the initial target. The study is a randomized, double-blind, placebo-controlled trial designed to assess the safety, tolerability, pharmacokinetics, biomarkers, and clinical effects of PMN310, which targets toxic soluble amyloid-beta oligomers. Interim blinded data from a 6-month analysis are expected in the second quarter of 2026, with final unblinded top-line results anticipated in the fourth quarter of 2026. No treatment-related serious adverse events have been reported so far. Results have not yet been presented.\n      </p>\n</div><div xmlns:xsd=\"http://www.w3.org/2001/XMLSchema\" xmlns:xsi=\"http://www.w3.org/2001/XMLSchema-instance\">\n<i>Disclaimer: <span>This news brief was created by Public Technologies (PUBT) using generative artificial intelligence. While PUBT strives to provide accurate and timely information, this AI-generated content is for informational purposes only and should not be interpreted as financial, investment, or legal advice. ProMIS Neurosciences Inc. published the original content used to generate this news brief via GlobeNewswire (Ref. ID: GNW9604315-en) on December 18, 2025, and is solely responsible for the information contained therein.</span></i>\n</div></body></html>\n</article>\n</div>\n</body>\n</html>\n","isBrief":false,"type":0,"news_type":1,"symbol":"IE00BKPKM429.USD","symbol_name":"NEUBERGER BERMAN GLOBAL SUSTAINABLE EQUITY \"A\" (USD) ACC","start_time":0,"source_url":"https://api.refinitiv.com/data/news/v1/stories/urn:newsml:reuters.com:20251218:nNDL49nLWY:1","article_id":"2592903776","we_media_id":"1032215980","thumbnails":[],"rights":null,"url":"https://stock-news.laohu8.com/highlight/detail?id=2592903776","pubTimestamp":1766061024,"columns":[],"sourceInfo":null,"weMediaInfo":{"media_name":"Reuters","introduction":"Reuters.com brings you the latest news from around the world, covering breaking news in markets, business, politics, entertainment and technology","home_visible":1,"id":"1032215980","head_image":"https://community-static.tradeup.com/news/4567337cbdf294b657b1fa87c5488b48"},"summary":"ProMIS Neurosciences Inc. has announced the completion of patient enrollment for its PRECISE-AD Phase 1b clinical trial of PMN310, a therapeutic antibody candidate for the treatment of Alzheimer's disease. 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The trial enrolled 144 patients with mild cognitive impairment or early Alzheimer's disease, exceeding the initial target. The study is a randomized, double-blind, placebo-controlled trial designed to assess the safety, tolerability, pharmacokinetics, biomarkers, and clinical effects of PMN310, which targets toxic soluble amyloid-beta oligomers. Interim blinded data from a 6-month analysis are expected in the second quarter of 2026, with final unblinded top-line results anticipated in the fourth quarter of 2026. No treatment-related serious adverse events have been reported so far. Results have not yet been presented.\n      \n\nDisclaimer: This news brief was created by Public Technologies (PUBT) using generative artificial intelligence. While PUBT strives to provide accurate and timely information, this AI-generated content is for informational purposes only and should not be interpreted as financial, investment, or legal advice. 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