Transthera Sciences Reports Positive Phase 2 Results for Tinengotinib in Cholangiocarcinoma
TransThera Sciences (Nanjing) Inc. has announced the publication of clinical results from a US-based Phase 2 trial evaluating its core product, Tinengotinib, in patients with cholangiocarcinoma $(CCA)$. The results were published in The Lancet Gastroenterology and Hepatology. The study involved patients with FGFR2 fusion-positive CCA who had either primary or acquired resistance to prior FGFR inhibitor therapy, as well as patients with other FGFR alterations or FGFR wild-type tumors. Tinengotinib demonstrated clinical activity in patients with FGFR2 fusion-positive CCA with acquired resistance to FGFR inhibitors, as well as in other FGFR-altered subtypes. The company notes there is no assurance that Tinengotinib will ultimately be successfully developed and marketed.
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