Taysha Gene Therapies Inc. has announced progress in its TSHA-102 pivotal gene therapy program for Rett syndrome. The company recently dosed the first patient in the REVEAL pivotal trial, which will enroll 15 female patients aged 6 to under 22 years. The trial is evaluating a single intrathecal administration of TSHA-102, an AAV9-based gene therapy, with response rate as the primary endpoint. Additionally, Taysha has reached written alignment with the FDA to include at least three months of safety data from the ASPIRE trial, involving patients aged 2 to under 4 years, in its planned Biologics License Application (BLA) submission. Completion of dosing in both the REVEAL and ASPIRE trials is expected in the second quarter of 2026. Longer-term safety and efficacy data from Part A of the REVEAL Phase 1/2 trials are expected to be available in the first half of 2026. Results from the trials have not yet been presented.

Disclaimer: This news brief was created by Public Technologies (PUBT) using generative artificial intelligence. While PUBT strives to provide accurate and timely information, this AI-generated content is for informational purposes only and should not be interpreted as financial, investment, or legal advice. Taysha Gene Therapies Inc. published the original content used to generate this news brief via GlobeNewswire (Ref. ID: 9620301) on January 06, 2026, and is solely responsible for the information contained therein.