Caris Life Sciences Inc. has published a new study in Nature's npj Breast Cancer journal detailing mechanisms of resistance to trastuzumab deruxtecan (T-DXd) in metastatic breast cancer. The study, which analyzed real-world data from 2,799 T-DXd-treated patients, identified ERBB2 (HER2) and ABCC1 as key transcriptomic predictors of overall survival specific to T-DXd treatment. Higher ERBB2 expression was associated with improved outcomes, while higher ABCC1 expression correlated with poorer outcomes, independent of HER2 category. The research also found that increased ABCC1 expression and enrichment of mutations in ERBB2, NFE2L2, KEAP1, and TOP1 were present in post-treatment samples, suggesting routes to acquired resistance. The results of this study have already been published.

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