Roche's CT-388 Could Compete With Lilly's Zepbound on Obesity Efficacy -- Market Talk

Dow Jones

01/27

0930 GMT - Roche Holding's results from a midstage study of obesity drug candidate CT-388 points to a competitive efficacy profile relative to Eli Lilly's Zepbound, but more data will be needed to make the comparison more accurate, J.P. Morgan analysts say in a research note. At 48 weeks, participants on the highest dose of CT-388 achieved a 22.5% weight loss when adjusting for placebo, while a separate Zepbound study showed a 17.9% reduction at that point, JPM says. Full data will be presented at an upcoming medical conference, and data on the baseline characteristics of the patients in the trial as well as the level of placebo weight loss will be key, according to JPM. Roche shares rise 0.6%. (adria.calatayud@wsj.com)

(END) Dow Jones Newswires

January 27, 2026 04:30 ET (09:30 GMT)

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Morgan analysts say in a research note. At 48 weeks, participants on the highest dose of CT-388 achieved a 22.5% weight loss when adjusting for placebo, while a separate Zepbound study showed a 17.9% reduction at that point, <a href=\"https://laohu8.com/S/JPM\">JPM</a> says. Full data will be presented at an upcoming medical conference, and data on the baseline characteristics of the patients in the trial as well as the level of placebo weight loss will be key, according to JPM. Roche shares rise 0.6%. (adria.calatayud@wsj.com) \n</p>\n<pre style=\"white-space: pre\">\n \n</pre>\n<p>\n  (END) Dow Jones Newswires\n</p>\n<p>\n  January 27, 2026 04:30 ET (09:30 GMT)\n</p>\n<p>\n  Copyright (c) 2026 Dow Jones &amp; Company, Inc.\n</p>\n</font>","source":null,"html":"<!DOCTYPE html>\n<html>\n<head>\n<meta http-equiv=\"Content-Type\" content=\"text/html; charset=utf-8\" />\n<meta name=\"viewport\" content=\"width=device-width,initial-scale=1.0,minimum-scale=1.0,maximum-scale=1.0,user-scalable=no\"/>\n<meta name=\"format-detection\" content=\"telephone=no,email=no,address=no\" />\n<title>Roche's CT-388 Could Compete With Lilly's Zepbound on Obesity Efficacy -- Market Talk</title>\n<style type=\"text/css\">\na,abbr,acronym,address,applet,article,aside,audio,b,big,blockquote,body,canvas,caption,center,cite,code,dd,del,details,dfn,div,dl,dt,\nem,embed,fieldset,figcaption,figure,footer,form,h1,h2,h3,h4,h5,h6,header,hgroup,html,i,iframe,img,ins,kbd,label,legend,li,mark,menu,nav,\nobject,ol,output,p,pre,q,ruby,s,samp,section,small,span,strike,strong,sub,summary,sup,table,tbody,td,tfoot,th,thead,time,tr,tt,u,ul,var,video{ font:inherit;margin:0;padding:0;vertical-align:baseline;border:0 }\nbody{ font-size:16px; line-height:1.5; color:#999; background:transparent; }\n.wrapper{ overflow:hidden;word-break:break-all;padding:10px; }\nh1,h2{ font-weight:normal; line-height:1.35; margin-bottom:.6em; }\nh3,h4,h5,h6{ line-height:1.35; margin-bottom:1em; }\nh1{ font-size:24px; }\nh2{ font-size:20px; }\nh3{ font-size:18px; }\nh4{ font-size:16px; }\nh5{ font-size:14px; }\nh6{ font-size:12px; }\np,ul,ol,blockquote,dl,table{ margin:1.2em 0; }\nul,ol{ margin-left:2em; }\nul{ list-style:disc; }\nol{ list-style:decimal; }\nli,li p{ margin:10px 0;}\nimg{ max-width:100%;display:block;margin:0 auto 1em; }\nblockquote{ color:#B5B2B1; border-left:3px solid #aaa; padding:1em; }\nstrong,b{font-weight:bold;}\nem,i{font-style:italic;}\ntable{ width:100%;border-collapse:collapse;border-spacing:1px;margin:1em 0;font-size:.9em; }\nth,td{ padding:5px;text-align:left;border:1px solid #aaa; }\nth{ font-weight:bold;background:#5d5d5d; }\n.symbol-link{font-weight:bold;}\n/* header{ border-bottom:1px solid #494756; } */\n.title{ margin:0 0 8px;line-height:1.3;color:#ddd; }\n.meta {color:#5e5c6d;font-size:13px;margin:0 0 .5em; }\na{text-decoration:none; color:#2a4b87;}\n.meta .head { display: inline-block; overflow: hidden}\n.head .h-thumb { width: 30px; height: 30px; margin: 0; padding: 0; border-radius: 50%; float: left;}\n.head .h-content { margin: 0; padding: 0 0 0 9px; float: left;}\n.head .h-name {font-size: 13px; color: #eee; margin: 0;}\n.head .h-time {font-size: 12.5px; color: #7E829C; margin: 0;}\n.small {font-size: 12.5px; display: inline-block; transform: scale(0.9); -webkit-transform: scale(0.9); transform-origin: left; -webkit-transform-origin: left;}\n.smaller {font-size: 12.5px; display: inline-block; transform: scale(0.8); -webkit-transform: scale(0.8); transform-origin: left; -webkit-transform-origin: left;}\n.bt-text {font-size: 12px;margin: 1.5em 0 0 0}\n.bt-text p {margin: 0}\n</style>\n</head>\n<body>\n<div class=\"wrapper\">\n<header>\n<h2 class=\"title\">\nRoche's CT-388 Could Compete With Lilly's Zepbound on Obesity Efficacy -- Market Talk\n</h2>\n<h4 class=\"meta\">\n<div class=\"head\" \">\n\n<div class=\"h-thumb\" style=\"background-image:url(https://static.tigerbbs.com/150f88aa4d182df19190059f4a365e99);background-size:cover;\"></div>\n\n<div class=\"h-content\">\n<p class=\"h-name\">Dow Jones </p>\n<p class=\"h-time smaller\">2026-01-27 17:30</p>\n</div>\n</div>\n</h4>\n</header>\n<article>\n<font class=\"NormalMinus1\" face=\"Arial\">\n<p>\n     0930 GMT - Roche Holding's results from a midstage study of obesity drug candidate CT-388 points to a competitive efficacy profile relative to Eli Lilly's Zepbound, but more data will be needed to make the comparison more accurate, J.P. Morgan analysts say in a research note. At 48 weeks, participants on the highest dose of CT-388 achieved a 22.5% weight loss when adjusting for placebo, while a separate Zepbound study showed a 17.9% reduction at that point, <a href=\"https://laohu8.com/S/JPM\">JPM</a> says. Full data will be presented at an upcoming medical conference, and data on the baseline characteristics of the patients in the trial as well as the level of placebo weight loss will be key, according to JPM. Roche shares rise 0.6%. (adria.calatayud@wsj.com) \n</p>\n<pre style=\"white-space: pre\">\n \n</pre>\n<p>\n  (END) Dow Jones Newswires\n</p>\n<p>\n  January 27, 2026 04:30 ET (09:30 GMT)\n</p>\n<p>\n  Copyright (c) 2026 Dow Jones &amp; Company, Inc.\n</p>\n</font>\n</article>\n</div>\n</body>\n</html>\n","isBrief":false,"type":0,"news_type":1,"symbol":"IE0005OL40V9.USD","symbol_name":"JANUS HENDERSON BALANCED \"A6M\" (USD) INC","start_time":0,"source_url":"https://dowjonesnews.com/newdjn/logon.aspx?AL=N","article_id":"2606202277","we_media_id":"106","thumbnails":[],"rights":null,"url":"https://stock-news.laohu8.com/highlight/detail?id=2606202277","pubTimestamp":1769506200,"columns":[],"sourceInfo":null,"weMediaInfo":{"media_name":"Dow Jones","introduction":"Dow Jones publishes the world’s most trusted business news and financial information in a variety of media.","home_visible":0,"id":"106","head_image":"https://static.tigerbbs.com/150f88aa4d182df19190059f4a365e99"},"summary":"0930 GMT - Roche Holding's results from a midstage study of obesity drug candidate CT-388 points to a competitive efficacy profile relative to Eli Lilly's Zepbound, but more data will be needed to make the comparison more accurate, J.P. Morgan analysts say in a research note. At 48 weeks, participants on the highest dose of CT-388 achieved a 22.5% weight loss when adjusting for placebo, while a separate Zepbound study showed a 17.9% reduction at that point, JPM says. Full data will be presented at an upcoming medical conference, and data on the baseline characteristics of the patients in the trial as well as the level of placebo weight loss will be key, according to JPM. Roche shares rise 0.6%. 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Roche Holding's results from a midstage study of obesity drug candidate CT-388 points to a competitive efficacy profile relative to Eli Lilly's Zepbound, but more data will be needed to make the comparison more accurate, J.P. Morgan analysts say in a research note. At 48 weeks, participants on the highest dose of CT-388 achieved a 22.5% weight loss when adjusting for placebo, while a separate Zepbound study showed a 17.9% reduction at that point, JPM says. Full data will be presented at an upcoming medical conference, and data on the baseline characteristics of the patients in the trial as well as the level of placebo weight loss will be key, according to JPM. Roche shares rise 0.6%. (adria.calatayud@wsj.com) \n\n\n \n\n\n  (END) Dow Jones Newswires\n\n\n  January 27, 2026 04:30 ET (09:30 GMT)\n\n\n  Copyright (c) 2026 Dow Jones & Company, Inc.","kind":"highlight","is_publish_news":true,"is_publish_highlight":false,"is_publish_live":false,"is_publish_wemedia":null,"editions":null,"column":"","sentiment":"1","news_tag":"","news_rank":0,"symbols":[],"gpt_button":0,"need_auth":true,"code":"91000000","status":"200"}}}