Press Release: Sana Biotechnology Reports Fourth Quarter and Full Year 2025 Financial Results and Business Updates

Dow Jones
03/04

Shared 12-month clinical results of ongoing UP421 type 1 diabetes study showing that hypoimmune-modified pancreatic islet cells transplanted without immunosuppression are safe and well-tolerated, evade detection by the immune system, and continue to function one year post-transplant

New England Journal of Medicine published positive 12-week clinical results of the UP421 type 1 diabetes study

Incorporating the tested hypoimmune technology to develop SC451, a hypoimmune-modified, stem cell-derived therapy, as a one-time treatment for patients with type 1 diabetes, with a goal of normal blood glucose, with no insulin and no immunosuppression

Made significant progress with SC451 across manufacturing, regulatory, and clinical trial preparedness, including the non-clinical testing plan and manufacture of the master cell bank

Expect to file investigational new drug application $(IND)$ for SC451 in type 1 diabetes and begin Phase 1 trial as early as this year

Expect to generate first-in-human data in blood cancers as early as this year for the next-generation in vivo CAR T product candidate, SG293, a CD8-targeted fusosome that delivers a CD19-directed CAR

Demonstrated deep B-cell depletion and immune reset with a single treatment in non-human primates with surrogate SG293

Raised aggregate gross proceeds of $133.7 million from sales of common stock through Sana's at the market offering facility (ATM) and equity financing in 2025

Q4 2025 cash position of $138.4 million and expected cash runway into late 2026

SEATTLE, March 03, 2026 (GLOBE NEWSWIRE) -- Sana Biotechnology, Inc. (NASDAQ: SANA), a company focused on creating and delivering engineered cells as medicines, today reported financial results and business highlights for the fourth quarter and year ended December 31, 2025.

"Meaningful scientific and operational progress in 2025 has positioned us well to generate human proof-of-concept data over the next 12-18 months for SC451 in type 1 diabetes and SG293 in blood cancers," said Steve Harr, Sana's President and Chief Executive Officer. "Clinical data for UP421, a study which is now out beyond a year, provide the first known example of transplanting an allogeneic cell therapy for the treatment of type 1 diabetes without any immunosuppression. These results, when combined with progress in the field of transplanting pancreatic islets, make us optimistic that SC451, which incorporates the same hypoimmune gene edits into a more scalable manufacturing platform, can lead to a functional cure for people with type 1 diabetes, meaning normal blood glucose, no more insulin injections, and no immunosuppression. Moving to the fusogen platform, we made improvements to our in vivo CAR T platform with our next--generation SG293 candidate, offering the potential for a simple, one-time, off-the-shelf treatment without the use of conditioning chemotherapy for the treatment of B cell cancers and B cell-mediated autoimmune diseases. We look forward to beginning clinical trials for both of these therapies this year. With two powerful platforms advancing in parallel, we look to drive meaningful clinical benefit for patients."

Corporate Highlights

Published positive results from an investigator-sponsored, first-in-human study transplanting UP421, an allogeneic primary islet cell therapy engineered with hypoimmune platform (HIP) technology, into a patient with type 1 diabetes without the use of any immunosuppression.

   -- UP421 is a primary human HIP-modified pancreatic islet cell therapy for 
      patients with type 1 diabetes. The goal of this investigator-sponsored 
      trial (IST) was to understand safety, immune evasion, islet cell survival, 
      and beta cell function, as measured by C-peptide production, of 
      HIP-modified pancreatic islet cells transplanted into a type 1 diabetes 
      patient without the use of any immunosuppression. The trial is being 
      conducted under a clinical trial authorization at Uppsala University 
      Hospital with Dr. Per-Ola Carlsson as the principal investigator. 
 
   -- Results of the study through one year after cell transplantation 
      demonstrate the survival and function of pancreatic beta cells as 
      measured by the presence of circulating C-peptide, a biomarker indicating 
      that transplanted beta cells are producing insulin. C-peptide levels also 
      increase with mixed meal tolerance tests performed over the course of the 
      study, consistent with insulin secretion in response to a meal. PET-MRI 
      scanning performed at week 12 and again at week 52 demonstrated islet 
      cells at the transplant site in the forearm. The study identified no 
      safety issues, and the HIP-modified islet cells evaded immune detection. 
 
   -- The New England Journal of Medicine (NEJM) published a journal article 
      titled "Survival of Transplanted Allogeneic Beta Cells with No 
      Immunosuppression" (DOI: 10.1056/NEJMoa2503822). The article discusses 
      12-week results from this study. NEJM also published an accompanying 
      editorial that further describes both the Sana technology and progress in 
      the field (DOI: 10.1056/NEJMe2507578). 

Advancing our focused pipeline across two platforms:

   -- Hypoimmune Platform -- Type 1 diabetes -- Sana continues development of 
      SC451, an O-negative, HIP-modified, iPSC-derived pancreatic islet cell 
      therapy, which uses the same HIP technology as UP421. Sana has had 
      multiple interactions with regulators over the last year, including FDA 
      INTERACT and Pre-IND meetings, the results of which increase confidence 
      in its manufacturing process, manufacturing controls, nonclinical testing 
      plan, and clinical trial plan. Sana expects to file an IND and begin a 
      Phase 1 clinical trial for SC451 as early as this year. 
 
   -- Fusogen Platform -- In vivo CAR T cells -- Sana continues to develop its 
      next-generation in vivo CAR T product candidate, SG293, which uses Sana's 
      proprietary fusogen delivery-based technology. SG293 is a CD8-targeted 
      fusosome that delivers to CD8+ T cells the genetic material to make 
      CD19-directed CAR T cells while avoiding potentially troublesome delivery 
      to tissues such as the liver. Preclinical data demonstrate that a SG293 
      surrogate achieves cell-specific delivery and deep B-cell depletion -- as 
      measured by depletion in circulating and lymph node B cells as well as a 
      phenotypic reset when B cells return -- in non-human primates without the 
      use of any lymphodepleting chemotherapy. Sana intends to explore SG293 in 
      both B-cell cancers and B-cell mediated autoimmune diseases and expects 
      to generate first-in-human data as early as this year. 

Published preclinical data in Nature Biotechnology demonstrating potent in vivo gene editing of hematopoietic stem cells (HSCs) in the bone marrow with systemic delivery in preclinical murine models using fusogen technology:

   -- The article describes a study that evaluated a systemically delivered 
      virus-like particle $(VLP)$ using the fusogen technology to target and gene 
      edit HSCs in vivo. Results show potent and cell-specific in vivo delivery 
      and gene editing of HSCs in the bone marrow in several murine models, 
      with stable gene editing of long-term HSCs. 
 
   -- This broadens the application of fusogen technology beyond T cells to a 
      second cell type, HSCs, and underscores the ability to deliver diverse 
      payloads, including CRISPR gene-editing and base-editing machinery. 

Raised aggregate gross proceeds of $133.7 million from sales of common stock through Sana's at-the-market offering facility (ATM) and equity financing in 2025; expected cash runway into late 2026.

   -- Closed public offering in August 2025 of 24.3 million shares of Sana's 
      common stock, including 3.4 million shares pursuant to the full exercise 
      of the underwriters' option to purchase additional shares, and pre-funded 
      warrants to purchase 1.5 million shares of Sana's common stock. The gross 
      proceeds from this offering were $86.3 million before deducting 
      underwriting discounts and commissions and offering expenses. 
 
   -- Raised gross proceeds of $47.4 million in 2025 from sales of common stock 
      through Sana's ATM. 

Strengthened leadership with the appointment of new Chief Financial Officer

   -- In the first quarter of 2026, appointed Brian Piper as Executive Vice 
      President, Chief Financial Officer. Mr. Piper has decades of experience 
      in financial management within the biotechnology sector -- including CFO 
      roles at Scorpion Therapeutics, Antares Therapeutics, and Prelude 
      Therapeutics -- and has successfully led financings and worked with 
      companies to maximize their assets. 

Fourth Quarter 2025 Financial Results

GAAP Results

   -- Cash Position: Cash, cash equivalents, and marketable securities as of 
      December 31, 2025 were $138.4 million compared to $152.5 million as of 
      December 31, 2024. The decrease of $14.1 million was primarily driven by 
      cash used in operations of $143.8 million, partially offset by net 
      proceeds from equity financings of $126.4 million, proceeds from stock 
      option exercises and Sana's employee stock purchase plan of $2.7 million, 
      and other cash inflows. 
 
   -- Research and Development Expenses: For the three and twelve months ended 
      December 31, 2025, research and development expenses, inclusive of 
      non-cash expenses, were $34.9 million and $132.0 million, respectively, 
      compared to $45.1 million and $215.7 million for the same periods in 
      2024. The decreases of $10.2 million and $83.7 million for the three and 
      twelve months ended December 31, 2025 compared to the same periods in 
      2024, respectively, were primarily due to the portfolio prioritization 
      announced in the fourth quarter of 2024, which resulted in a reduction of 
      the scope of research, laboratory, and clinical development activities, 
      lower personnel-related costs, including non-cash stock-based 
      compensation, and a decrease in facility and other allocated costs. 
      Research and development expenses include non-cash stock-based 
      compensation of $3.2 million and $15.2 million, respectively, for the 
      three and twelve months ended December 31, 2025, and $3.9 million and 
      $23.4 million for the same periods in 2024. 
 
   -- Research and Development Related Success Payments and Contingent 
      Consideration: For the three and twelve months ended December 31, 2025, 
      Sana recognized non-cash expenses of $14.1 million and $29.4 million, 
      respectively, compared to non-cash gains of $13.4 million and $8.9 
      million for the same periods in 2024, in connection with the change in 
      the estimated fair value of the success payment liabilities and 
      contingent consideration in aggregate. The value of these potential 
      liabilities fluctuates significantly with changes in Sana's market 
      capitalization and stock price. 
 
   -- General and Administrative Expenses: General and administrative expenses 
      for the three and twelve months ended December 31, 2025, inclusive of 
      non-cash expenses, were $12.2 million and $44.3 million, respectively, 
      compared to $17.3 million and $64.0 million for the same periods in 2024. 
      The decrease of $5.1 million for the three months ended December 31, 2025 
      compared to the same period in 2024 was primarily due to 
      personnel-related costs incurred in connection with the portfolio 
      prioritization announced in the fourth quarter of 2024. The decrease of 
      $19.7 million for the twelve months ended December 31, 2025 compared to 
      the same period in 2024 was primarily due to lower personnel-related 
      costs, including non-cash stock-based compensation, due to a decrease in 
      headcount in connection with the portfolio prioritization announced in 
      the fourth quarter of 2024, and decreased legal and consulting fees. 
      General and administrative expenses include non-cash stock-based 
      compensation of $3.2 million and $10.3 million for the three and twelve 
      months ended December 31, 2025, respectively, compared to $2.5 million 
      and $14.3 million for the same periods in 2024. 
 
   -- Impairment of Long-Lived Assets: For the twelve months ended December 31, 
      2025, non-cash impairment of long-lived assets was $44.6 million, 
      compared to $1.9 million for the same period in 2024. The non-cash 
      impairment of $44.6 million recorded in the second quarter of 2025 was 
      primarily related to Sana's manufacturing facility in Bothell, Washington 
      and certain laboratory and office space in Seattle, Washington. Because 
      of the increased availability of manufacturing capacity at third-party 
      contract development and manufacturing organizations (CDMOs) for cell and 
      gene therapy products as well as progress in understanding its near-term 
      manufacturing needs, Sana expects to use CDMOs to meet its manufacturing 
      needs at present and has suspended further build-out of internal 
      manufacturing capabilities. Impairment of long-lived assets in 2024 
      consists of non-cash losses recognized for the impairment of certain 
      laboratory equipment and leasehold improvements as a result of the 
      portfolio prioritization in the fourth quarter of 2024. 
 
   -- Net Loss: Net loss for the three and twelve months ended December 31, 
      2025 was $58.8 million, or $0.21 per share, and $244.2 million, or $0.96 
      per share, respectively, compared to $49.1 million, or $0.21 per share, 
      and $266.8 million, or $1.16 per share, for the same periods in 2024. 

Non-GAAP Measures

   -- Non-GAAP Operating Cash Burn: Non-GAAP operating cash burn for the twelve 
      months ended December 31, 2025 was $138.5 million compared to $195.1 
      million for the same period in 2024. Non-GAAP operating cash burn is the 
      decrease in cash, cash equivalents, and marketable securities, excluding 
      cash inflows from financing activities, costs related to portfolio 
      prioritizations, and the purchase of property and equipment. 
 
   -- Non-GAAP General and Administrative Expenses: Non-GAAP general and 
      administrative expenses for the three and twelve months ended December 
      31, 2025 were $12.2 million and $44.3 million, respectively, compared to 
      $11.4 million and $58.2 million for the same periods in 2024. Non-GAAP 
      general and administrative expense excludes personnel-related costs 
      related to the portfolio prioritization in the fourth quarter of 2024. 
 
   -- Non-GAAP Net Loss: Non-GAAP net loss for the three and twelve months 
      ended December 31, 2025 was $44.7 million, or $0.16 per share, and $170.1 
      million, or $0.67 per share, respectively, compared to $54.8 million, or 
      $0.23 per share, and $263.1 million, or $1.14 per share, for the same 
      periods in 2024. Non-GAAP net loss excludes non-cash expenses and gains 
      related to the change in the estimated fair value of contingent 
      consideration and success payment liabilities, and non-cash impairment 
      losses recorded in 2025 and 2024. 

A discussion of non-GAAP measures, including a reconciliation of GAAP and non-GAAP measures, is presented below under "Non-GAAP Financial Measures."

About Sana

Sana Biotechnology, Inc. is focused on creating and delivering engineered cells as medicines for patients. We share a vision of repairing and controlling genes, replacing missing or damaged cells, and making our therapies broadly available to patients. We are a passionate group of people working together to create an enduring company that changes how the world treats disease. Sana has operations in Seattle, WA, Cambridge, MA, and South San Francisco, CA.

Cautionary Note Regarding Forward-Looking Statements

This press release contains forward-looking statements about Sana Biotechnology, Inc. (the "Company," "we," "us," or "our") within the meaning of the federal securities laws, including those related to the Company's vision, progress, and business plans; expectations for its development programs, product candidates, and technology platforms, including its preclinical, clinical, and regulatory development plans and timing expectations, including with respect to the substance and timing of potential INDs, the commencement of clinical trials and generation of human data, and potential indications for and the potential impact and benefits of its platforms and product candidates; expectations with respect to the impact of regulatory interactions and the ability to move forward with the Company's SC451 manufacturing process, manufacturing controls, nonclinical testing plan, and clinical trial plan; the potential ability for SG293 to be a simple, one-time, off-the-shelf treatment without the use of conditioning chemotherapy; expectations with respect to manufacturing and scalability of SC451 and the potential ability for SC451 in type 1 diabetes to be a single treatment that restores normal blood glucose without insulin or immunosuppression and lead to a functional cure for people with type 1 diabetes; expectations regarding the significance and impact of data from preclinical studies and clinical trials of the Company's product candidates and technologies, including the potential breadth of application and ability of the fusogen technology to deliver diverse payloads, and an IST utilizing HIP-modified primary pancreatic islet cells; expectations regarding the Company's cash runway; expectations regarding the use of CDMOs; and statements made by the Company's President and Chief Executive Officer. All statements other than statements of historical facts contained in this press release, including, among others, statements regarding the Company's strategy, expectations, cash runway and future financial condition, future operations, and prospects, are forward-looking statements. In some cases, you can identify forward-looking statements by terminology such as "aim, " "anticipate," "assume," "believe," "contemplate," "continue," "could," "design," "due," "estimate," "expect," "goal," "intend," "may," "objective," "plan," "positioned," "potential," "predict," "seek," "should," "target," "will," "would," and other similar expressions that are predictions of or indicate future events and future trends, or the negative of these terms or other comparable terminology. The Company has based these forward-looking statements largely on its current expectations, estimates, forecasts and projections about future events and financial trends that it believes may affect its financial condition, results of operations, business strategy and financial needs. In light of the significant uncertainties in these forward-looking statements, you should not rely upon forward-looking statements as predictions of future events. These statements are subject to risks and uncertainties that could cause the actual results to vary materially, including, among others, the risks inherent in drug development such as those associated with the initiation, cost, timing, progress and results of the Company's current and future research and development programs, preclinical and clinical trials, as well as economic, market, and social disruptions. For a detailed discussion of the risk factors that could affect the Company's actual results, please refer to the risk factors identified in the Company's Securities and Exchange Commission (SEC) reports, including but not limited to its Annual Report on Form 10-K dated March 3, 2026. Except as required by law, the Company undertakes no obligation to update publicly any forward-looking statements for any reason.

Investor Relations & Media:

Nicole Keith

investor.relations@sana.com

media@sana.com

 
                        Sana Biotechnology, Inc. 
           Unaudited Selected Consolidated Balance Sheet Data 
                               December 31, 2025    December 31, 2024 
                              -------------------  ------------------- 
                                           (in thousands) 
Cash, cash equivalents, and 
 marketable securities          $         138,382    $         152,497 
Total assets                              416,890              501,020 
Contingent consideration                  123,718              108,968 
Success payment liabilities                19,238                4,556 
Total liabilities                         256,006              250,516 
Total stockholders' equity                160,884              250,504 
 
 
                      Sana Biotechnology, Inc. 
           Unaudited Consolidated Statements of Operations 
                      Three Months Ended     Twelve Months Ended 
                         December 31,           December 31, 
                     --------------------   --------------------- 
                       2025       2024        2025        2024 
                     --------   ---------   ---------   --------- 
                        (in thousands, except per share data) 
Operating 
expenses: 
   Research and 
    development      $ 34,924   $  45,145   $ 131,980   $ 215,673 
   Research and 
    development 
    related success 
    payments and 
    contingent 
    consideration      14,089     (13,447)     29,432      (8,881) 
   General and 
    administrative     12,186      17,277      44,296      64,040 
   Impairment of 
    long-lived 
    assets                 --       1,891      44,611       1,891 
                      -------    --------    --------    -------- 
      Total 
       operating 
       expenses        61,199      50,866     250,319     272,723 
                      -------    --------    --------    -------- 
Loss from 
 operations           (61,199)    (50,866)   (250,319)   (272,723) 
Interest income, 
 net                    1,276       1,656       3,848      10,471 
Other income 
 (expense), net         1,098         141       2,305      (4,507) 
                      -------    --------    --------    -------- 
Net loss             $(58,825)  $ (49,069)  $(244,166)  $(266,759) 
                      =======    ========    ========    ======== 
Net loss per common 
 share -- basic and 
 diluted             $  (0.21)  $   (0.21)  $   (0.96)  $   (1.16) 
                      -------    --------    --------    -------- 
Weighted-average 
 number of common 
 shares -- basic 
 and diluted          275,882     236,299     253,234     230,891 
                      =======    ========    ========    ======== 
 
 
                     Sana Biotechnology, Inc. 
      Changes in the Estimated Fair Value of Success Payments 
                   and Contingent Consideration 
                                                  Total Success 
                                                     Payment 
                 Success                          Liability and 
                 Payment         Contingent         Contingent 
              Liability(1)    Consideration(2)    Consideration 
              -------------  ------------------   -------------- 
                                (in thousands) 
Liability 
 balance as 
 of December 
 31, 2024     $       4,556   $         108,968   $      113,524 
   Changes 
    in fair 
    value -- 
    expense              93               1,864            1,957 
               ------------      --------------    ------------- 
Liability 
 balance as 
 of March 
 31, 2025             4,649             110,832          115,481 
   Changes 
    in fair 
    value -- 
    expense           3,962               6,300           10,262 
               ------------      --------------    ------------- 
Liability 
 balance as 
 of June 30, 
 2025                 8,611             117,132          125,743 
   Changes 
    in fair 
    value -- 
    expense 
    (gain)            5,115              (1,991)           3,124 
               ------------      --------------    ------------- 
Liability 
 balance as 
 of 
 September 
 30, 2025            13,726             115,141          128,867 
   Changes 
    in fair 
    value -- 
    expense           5,512               8,577           14,089 
               ------------      --------------    ------------- 
Liability 
 balance as 
 of December 
 31, 2025     $      19,238   $         123,718   $      142,956 
               ============      ==============    ============= 
Total change 
 in fair 
 value for 
 the twelve 
 months 
 ended 
 December 
 31, 2025     $      14,682   $          14,750   $       29,432 
               ============      ==============    ============= 
 
 (1) Cobalt Biomedicine, Inc. (Cobalt) and the President 
 and Fellows of Harvard College (Harvard) are entitled 
 to success payments pursuant to the terms and conditions 
 of their respective agreements. The success payments 
 are recorded at fair value and remeasured at each 
 reporting period with changes in the estimated fair 
 value recorded in research and development related 
 success payments and contingent consideration on the 
 statement of operations. 
 (2) Cobalt is entitled to contingent consideration 
 upon the achievement of certain milestones pursuant 
 to the terms and conditions of the agreement. Contingent 
 consideration is recorded at fair value and remeasured 
 at each reporting period with changes in the estimated 
 fair value recorded in research and development related 
 success payments and contingent consideration on the 
 statement of operations. 
 

Non-GAAP Financial Measures

To supplement the financial results presented in accordance with generally accepted accounting principles in the United States (GAAP), Sana uses certain non-GAAP financial measures to evaluate its business. Sana's management believes that these non-GAAP financial measures are helpful in understanding Sana's financial performance and potential future results, as well as providing comparability to peer companies and period over period. In particular, Sana's management utilizes non-GAAP operating cash burn, non-GAAP research and development expense, non-GAAP general and administrative expense, and non-GAAP net loss and net loss per share. Sana believes the presentation of these non-GAAP measures provides management and investors greater visibility into the company's actual ongoing costs to operate its business, including actual research and development costs unaffected by non-cash valuation changes and certain one-time expenses for acquiring technology, as well as facilitating a more meaningful comparison of period-to-period activity. Sana excludes these items because they are highly variable from period to period and, in respect of the non-cash expenses, provide investors with insight into the actual cash investment in the development of its therapeutic programs and platform technologies.

These are not meant to be considered in isolation or as a substitute for comparable GAAP measures and should be read in conjunction with Sana's financial statements prepared in accordance with GAAP. These non-GAAP measures differ from GAAP measures with the same captions, may be different from non-GAAP financial measures with the same or similar captions that are used by other companies, and do not reflect a comprehensive system of accounting. Sana's management uses these supplemental non-GAAP financial measures internally to understand, manage, and evaluate Sana's business and make operating decisions. In addition, Sana's management believes that the presentation of these non-GAAP financial measures is useful to investors because they enhance the ability of investors to compare Sana's results from period to period and allow for greater transparency with respect to key financial metrics Sana uses in making operating decisions. The following are reconciliations of GAAP to non-GAAP financial measures:

 
                        Sana Biotechnology, Inc. 
      Unaudited Reconciliation of Change in Cash, Cash Equivalents, 
                      and Marketable Securities to 
                      Non-GAAP Operating Cash Burn 
                                  Twelve Months Ended December 31, 
                               -------------------------------------- 
                                      2025                  2024 
                               ------------------      -------------- 
                                           (in thousands) 
Beginning cash, cash 
 equivalents, and marketable 
 securities                     $         152,497      $      205,195 
Ending cash, cash 
 equivalents, and marketable 
 securities                               138,382             152,497 
                                   --------------       ------------- 
Change in cash, cash 
 equivalents, and marketable 
 securities                               (14,115)            (52,698) 
   Cash paid to purchase 
    property and equipment                    938              33,430 
                                   --------------       ------------- 
Change in cash, cash 
 equivalents, and marketable 
 securities, excluding 
 capital expenditures                     (13,177)            (19,268) 
Adjustments: 
   Net proceeds from issuance 
    of common stock                      (126,404)           (181,000) 
   Cash paid for 
    personnel-related costs 
    incurred in connection 
    with portfolio 
    prioritizations                         1,062               5,158 
Operating cash burn -- 
 Non-GAAP                       $        (138,519)     $     (195,110) 
                                   ==============       ============= 
 
 
                     Sana Biotechnology, Inc. 
       Unaudited Reconciliation of GAAP to Non-GAAP General 
                    and Administrative Expense 
                                               Twelve Months 
                        Three Months Ended     Ended December 
                           December 31,             31, 
                        ------------------   ------------------ 
                         2025      2024       2025      2024 
                        -------  ---------   -------  --------- 
                                    (in thousands) 
General and 
 administrative -- 
 GAAP                   $12,186  $  17,277   $44,296  $  64,040 
Adjustments: 
   Personnel-related 
    costs incurred in 
    connection with 
    portfolio 
    prioritization           --     (5,840)       --     (5,840) 
General and 
 administrative -- 
 Non-GAAP               $12,186  $  11,437   $44,296  $  58,200 
                         ======   ========    ======   ======== 
 
 
                       Sana Biotechnology, Inc. 
         Unaudited Reconciliation of GAAP to Non-GAAP Net Loss 
                         and Net Loss Per Share 
                         Three Months Ended     Twelve Months Ended 
                            December 31,           December 31, 
                        --------------------   --------------------- 
                          2025       2024        2025        2024 
                        --------   ---------   ---------   --------- 
                           (in thousands, except per share data) 
Net loss -- GAAP        $(58,825)  $ (49,069)  $(244,166)  $(266,759) 
Adjustments: 
   Change in the 
    estimated fair 
    value of the 
    success payment 
    liabilities(1)         5,512     (10,559)     14,682      (8,243) 
   Change in the 
    estimated fair 
    value of 
    contingent 
    consideration(2)       8,577      (2,888)     14,750        (638) 
   Personnel-related 
    costs incurred in 
    connection with 
    portfolio 
    prioritization            --       5,840          --       5,840 
   Impairment of 
    long-lived assets         --       1,891      44,611       1,891 
   Impairment of other 
    assets                    --          --          --       4,832 
                         -------    --------    --------    -------- 
Net loss -- Non-GAAP    $(44,736)  $ (54,785)  $(170,123)  $(263,077) 
                         =======    ========    ========    ======== 
Net loss per share -- 
 GAAP                   $  (0.21)  $   (0.21)  $   (0.96)  $   (1.16) 
Adjustments: 
   Change in the 
    estimated fair 
    value of the 
    success payment 
    liabilities(1)          0.02       (0.04)       0.06       (0.04) 
   Change in the 
    estimated fair 
    value of 
    contingent 
    consideration(2)        0.03       (0.01)       0.06          -- 
   Personnel-related 
    costs incurred in 
    connection with 
    portfolio 
    prioritization            --        0.02          --        0.03 
   Impairment of 
    long-lived assets         --        0.01        0.17        0.01 
   Impairment of other 
    assets                    --          --          --        0.02 
                         -------    --------    --------    -------- 
Net loss per share -- 
 Non-GAAP               $  (0.16)  $   (0.23)  $   (0.67)  $   (1.14) 
                         =======    ========    ========    ======== 
Weighted-average 
 shares outstanding -- 
 basic and diluted       275,882     236,299     253,234     230,891 
                         =======    ========    ========    ======== 
 
 (1) For the three months ended December 31, 2025, 
 the expense related to the Cobalt success payment 
 liability was $5.1 million compared to a gain of $9.2 
 million for the same period in 2024. For the twelve 
 months ended December 31, 2025, the expense related 
 to the Cobalt success payment liability was $13.6 
 million compared to a gain of $6.9 million for the 
 same period in 2024. For the three months ended December 
 31, 2025, the expense related to the Harvard success 
 payment liabilities was $0.4 million compared to a 
 gain of $1.3 million for the same period in 2024. 
 For the twelve months ended December 31, 2025, the 
 expense related to the Harvard success payment liabilities 
 was $1.1 million compared to a gain of $1.3 million 
 for the same period in 2024. 
 (2) The contingent consideration is in connection 
 with the acquisition of Cobalt. 
 

(END) Dow Jones Newswires

March 03, 2026 16:05 ET (21:05 GMT)

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