European equities traded in the US as American depositary receipts edged lower late Wednesday morning, declining 0.12% to 1,758.23 on the S&P Europe Select ADR Index.

From continental Europe, the gainers were led by biotech firm BioNTech (BNTX) and petroleum refiner Equinor (EQNR), which advanced 8% and 2.4%, respectively. They were followed by internet browser company Opera (OPRA) and telecommunications company Ericsson (ERIC), which were up 1.5% and 1.2%.

The decliners from continental Europe were led by biopharmaceutical companies DBV Technologies (DBVT) and Grifols (GRFS), which fell 4.5% and 2% respectively. They were followed by consumer goods company Unilever (UL) and software firm SAP (SAP), which dropped 1.6% and 1.5%.

From the UK and Ireland, the gainers were led by software company Endava (DAVA) and oil and gas company BP (BP), which rose 2% and 1.9% respectively. They were followed by oil and gas company Shell (SHEL) and communications company WPP (WPP), which increased 1.3% and 1.1%

The decliners from the UK and Ireland were led by biopharmaceutical company Biodexa Pharmaceuticals (BDRX) and biotech firm Autolus Therapeutics (AUTL), which dropped 4.1% and 2.2% respectively. They were followed by biopharmaceutical company NuCana (NCNA) and cruise line operator Carnival (CUK), which lost 1.8% and 1.2%.