Aardvark 在審查副作用時暫停兩項肥胖症藥物試驗

路透中文

5小時前

路透3月23日 - Aardvark Therapeutics AARD.O周一表示，由於要審查其中一種藥物的副作用，它已主動暫停了兩項肥胖症試驗性聯合療法的中期研究。

這種名為ARD-201的聯合療法正在接受測試，目的是誘導那些服用流行的GLP-1類藥物（包括禮來公司的LLY.N Zepbound和諾和諾德公司的NOVOb.CO Wegovy）後體重下降約15%的患者減輕體重並防止體重反彈。
ARD-201是Aardvark的實驗藥物ARD-101與默克公司的糖尿病藥物MRK.N Januvia（化學名稱為西格列汀）的組合。
ARD-101旨在觸發包括GLP-1在內的多種腸肽激素的釋放，以調節飢餓感。
上個月，該公司在一項健康志願者研究中對 ARD-101 進行安全監測時發現了與心臟有關的副作用。隨後，該公司暫停了一項後期試驗 (link)，即在患有罕見遺傳性疾病普拉德-威利綜合症的患者中測試 ARD-101。
Aardvark公司表示，預計將在2026年第二季度提供有關這些藥物的進一步更新信息。

(為便利非英文母語者，路透將其報導自動化翻譯為數種其他語言。由於自動化翻譯可能有誤，或未能包含所需語境，路透不保證自動化翻譯文本的準確性，僅是為了便利讀者而提供自動化翻譯。對於因為使用自動化翻譯功能而造成的任何損害或損失，路透不承擔任何責任。)

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</span><a href=\"https://laohu8.com/S/AARD\">Aardvark Therapeutics</a> <span>AARD.O</span>周一表示，由於要審查其中一種藥物的副作用，它已主動暫停了兩項肥胖症試驗性聯合療法的中期研究。</p><ul><li><p>這種名為ARD-201的聯合療法正在接受測試，目的是誘導那些服用流行的GLP-1類藥物（包括<a href=\"https://laohu8.com/S/LLY\">禮來</a>公司的<span>LLY.N</span> Zepbound和<a href=\"https://laohu8.com/S/NVO\">諾和諾德</a>公司的<span>NOVOb.CO</span> Wegovy）後體重下降約15%的患者減輕體重並防止體重反彈。</p></li><li><p>ARD-201是Aardvark的實驗藥物ARD-101與默克公司的糖尿病藥物<span>MRK.N</span> Januvia（化學名稱為西格列汀）的組合。</p></li><li><p>ARD-101旨在觸發包括GLP-1在內的多種腸肽激素的釋放，以調節飢餓感。</p></li><li><p>上個月，該公司在一項健康志願者研究中對 ARD-101 進行安全監測時發現了與心臟有關的副作用。隨後，該公司暫停了一項後期試驗 (<span>link</span>)，即在患有罕見遺傳性疾病普拉德-威利綜合症的患者中測試 ARD-101。</p></li><li><p>Aardvark公司表示，預計將在2026年第二季度提供有關這些藥物的進一步更新信息。</p></li></ul><p>(為便利非英文母語者，路透將其報導自動化翻譯為數種其他語言。由於自動化翻譯可能有誤，或未能包含所需語境，路透不保證自動化翻譯文本的準確性，僅是為了便利讀者而提供自動化翻譯。對於因為使用自動化翻譯功能而造成的任何損害或損失，路透不承擔任何責任。)</p></body></html>","source":null,"html":"<!DOCTYPE html>\n<html>\n<head>\n<meta http-equiv=\"Content-Type\" content=\"text/html; charset=utf-8\" />\n<meta name=\"viewport\" content=\"width=device-width,initial-scale=1.0,minimum-scale=1.0,maximum-scale=1.0,user-scalable=no\"/>\n<meta name=\"format-detection\" content=\"telephone=no,email=no,address=no\" />\n<title>Aardvark 在審查副作用時暫停兩項肥胖症藥物試驗</title>\n<style type=\"text/css\">\na,abbr,acronym,address,applet,article,aside,audio,b,big,blockquote,body,canvas,caption,center,cite,code,dd,del,details,dfn,div,dl,dt,\nem,embed,fieldset,figcaption,figure,footer,form,h1,h2,h3,h4,h5,h6,header,hgroup,html,i,iframe,img,ins,kbd,label,legend,li,mark,menu,nav,\nobject,ol,output,p,pre,q,ruby,s,samp,section,small,span,strike,strong,sub,summary,sup,table,tbody,td,tfoot,th,thead,time,tr,tt,u,ul,var,video{ font:inherit;margin:0;padding:0;vertical-align:baseline;border:0 }\nbody{ font-size:16px; line-height:1.5; color:#999; background:transparent; }\n.wrapper{ overflow:hidden;word-break:break-all;padding:10px; }\nh1,h2{ font-weight:normal; line-height:1.35; margin-bottom:.6em; }\nh3,h4,h5,h6{ line-height:1.35; margin-bottom:1em; }\nh1{ font-size:24px; }\nh2{ font-size:20px; }\nh3{ font-size:18px; }\nh4{ font-size:16px; }\nh5{ font-size:14px; }\nh6{ font-size:12px; }\np,ul,ol,blockquote,dl,table{ margin:1.2em 0; }\nul,ol{ margin-left:2em; }\nul{ list-style:disc; }\nol{ list-style:decimal; }\nli,li p{ margin:10px 0;}\nimg{ max-width:100%;display:block;margin:0 auto 1em; }\nblockquote{ color:#B5B2B1; border-left:3px solid #aaa; padding:1em; }\nstrong,b{font-weight:bold;}\nem,i{font-style:italic;}\ntable{ width:100%;border-collapse:collapse;border-spacing:1px;margin:1em 0;font-size:.9em; }\nth,td{ padding:5px;text-align:left;border:1px solid #aaa; }\nth{ font-weight:bold;background:#5d5d5d; }\n.symbol-link{font-weight:bold;}\n/* header{ border-bottom:1px solid #494756; } */\n.title{ margin:0 0 8px;line-height:1.3;color:#ddd; }\n.meta {color:#5e5c6d;font-size:13px;margin:0 0 .5em; }\na{text-decoration:none; color:#2a4b87;}\n.meta .head { display: inline-block; overflow: hidden}\n.head .h-thumb { width: 30px; height: 30px; margin: 0; padding: 0; border-radius: 50%; float: left;}\n.head .h-content { margin: 0; padding: 0 0 0 9px; float: left;}\n.head .h-name {font-size: 13px; color: #eee; margin: 0;}\n.head .h-time {font-size: 12.5px; color: #7E829C; margin: 0;}\n.small {font-size: 12.5px; display: inline-block; transform: scale(0.9); -webkit-transform: scale(0.9); transform-origin: left; -webkit-transform-origin: left;}\n.smaller {font-size: 12.5px; display: inline-block; transform: scale(0.8); -webkit-transform: scale(0.8); transform-origin: left; -webkit-transform-origin: left;}\n.bt-text {font-size: 12px;margin: 1.5em 0 0 0}\n.bt-text p {margin: 0}\n</style>\n</head>\n<body>\n<div class=\"wrapper\">\n<header>\n<h2 class=\"title\">\nAardvark 在審查副作用時暫停兩項肥胖症藥物試驗\n</h2>\n<h4 class=\"meta\">\n<a class=\"head\" href=\"https://laohu8.com/wemedia/1098195322\">\n\n<div class=\"h-thumb\" style=\"background-image:url(https://community-static.tradeup.com/news/4567337cbdf294b657b1fa87c5488b48);background-size:cover;\"></div>\n\n<div class=\"h-content\">\n<p class=\"h-name\">路透中文 </p>\n<p class=\"h-time smaller\">2026-03-24 05:52</p>\n</div>\n</a>\n</h4>\n</header>\n<article>\n<html xmlns=\"http://www.w3.org/1999/xhtml\"><head><title>Aardvark 在審查副作用時暫停兩項肥胖症藥物試驗</title></head><body><p>\n<span>路透3月23日</span><span> - </span><a href=\"https://laohu8.com/S/AARD\">Aardvark Therapeutics</a> <span>AARD.O</span>周一表示，由於要審查其中一種藥物的副作用，它已主動暫停了兩項肥胖症試驗性聯合療法的中期研究。</p><ul><li><p>這種名為ARD-201的聯合療法正在接受測試，目的是誘導那些服用流行的GLP-1類藥物（包括<a href=\"https://laohu8.com/S/LLY\">禮來</a>公司的<span>LLY.N</span> Zepbound和<a href=\"https://laohu8.com/S/NVO\">諾和諾德</a>公司的<span>NOVOb.CO</span> Wegovy）後體重下降約15%的患者減輕體重並防止體重反彈。</p></li><li><p>ARD-201是Aardvark的實驗藥物ARD-101與默克公司的糖尿病藥物<span>MRK.N</span> Januvia（化學名稱為西格列汀）的組合。</p></li><li><p>ARD-101旨在觸發包括GLP-1在內的多種腸肽激素的釋放，以調節飢餓感。</p></li><li><p>上個月，該公司在一項健康志願者研究中對 ARD-101 進行安全監測時發現了與心臟有關的副作用。隨後，該公司暫停了一項後期試驗 (<span>link</span>)，即在患有罕見遺傳性疾病普拉德-威利綜合症的患者中測試 ARD-101。</p></li><li><p>Aardvark公司表示，預計將在2026年第二季度提供有關這些藥物的進一步更新信息。</p></li></ul><p>(為便利非英文母語者，路透將其報導自動化翻譯為數種其他語言。由於自動化翻譯可能有誤，或未能包含所需語境，路透不保證自動化翻譯文本的準確性，僅是為了便利讀者而提供自動化翻譯。對於因為使用自動化翻譯功能而造成的任何損害或損失，路透不承擔任何責任。)</p></body></html>\n</article>\n</div>\n</body>\n</html>\n","isBrief":false,"type":0,"news_type":1,"symbol":"LU2491050154.USD","symbol_name":"WELLINGTON SUSTAINABLE OUTCOMES \"A\" (USD) ACC","start_time":0,"source_url":"https://api.refinitiv.com/data/news/v1/stories/urn:newsml:reuters.com:20260323:nL4S40B1XI:1","article_id":"2621041087","we_media_id":"1098195322","thumbnails":[],"rights":null,"url":"https://stock-news.laohu8.com/highlight/detail?id=2621041087","pubTimestamp":1774302743,"columns":[],"sourceInfo":null,"weMediaInfo":{"media_name":"路透中文","introduction":"路透中文","home_visible":1,"id":"1098195322","head_image":"https://community-static.tradeup.com/news/4567337cbdf294b657b1fa87c5488b48"},"summary":"路透3月23日 - 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Aardvark Therapeutics AARD.O周一表示，由於要審查其中一種藥物的副作用，它已主動暫停了兩項肥胖症試驗性聯合療法的中期研究。這種名為ARD-201的聯合療法正在接受測試，目的是誘導那些服用流行的GLP-1類藥物（包括禮來公司的LLY.N Zepbound和諾和諾德公司的NOVOb.CO Wegovy）後體重下降約15%的患者減輕體重並防止體重反彈。ARD-201是Aardvark的實驗藥物ARD-101與默克公司的糖尿病藥物MRK.N Januvia（化學名稱為西格列汀）的組合。ARD-101旨在觸發包括GLP-1在內的多種腸肽激素的釋放，以調節飢餓感。上個月，該公司在一項健康志願者研究中對 ARD-101 進行安全監測時發現了與心臟有關的副作用。隨後，該公司暫停了一項後期試驗 (link)，即在患有罕見遺傳性疾病普拉德-威利綜合症的患者中測試 ARD-101。Aardvark公司表示，預計將在2026年第二季度提供有關這些藥物的進一步更新信息。(為便利非英文母語者，路透將其報導自動化翻譯為數種其他語言。由於自動化翻譯可能有誤，或未能包含所需語境，路透不保證自動化翻譯文本的準確性，僅是為了便利讀者而提供自動化翻譯。對於因為使用自動化翻譯功能而造成的任何損害或損失，路透不承擔任何責任。)","kind":"highlight","is_publish_news":true,"is_publish_highlight":false,"is_publish_live":false,"is_publish_wemedia":null,"editions":null,"column":"","sentiment":"-1","news_tag":"","news_rank":0,"symbols":[],"gpt_button":1,"need_auth":true,"code":"91000000","status":"200"}}}