Cullinan Therapeutics Shares Rise on Positive Early Trial Data for Autoimmune Drug

Dow Jones

06/08

By Adriano Marchese

Cullinan Therapeutics shares rose in premarket trading Monday after the company reported that preliminary data showed its experimental T-cell engager produced encouraging clinical responses in lupus and rheumatoid arthritis patients.

Shares traded 9.6% higher ahead of the morning bell at $14.81.

The clinical-stage biopharmaceutical said a single dose of its CD19xCD3 T-cell engager, called CLN-978, led to clinical improvements and even remissions in patients with hard-to-treat lupus and rheumatoid arthritis.

A CD19xCD3 T-cell engager is a type of next-generation immune therapy designed to force T-cells to kill B-cells, the kind that sustain autoimmune diseases like lupus and rheumatoid arthritis.

Cullinan said that the early results showed deep, dose-dependent B-cell depletion and a safety profile that it said supports further clinical development.

"We are focused on advancing CLN-978 rapidly through global clinical development to accelerate bringing this new therapeutic option to patients," Chief Medical Officer Jeffrey Jones said.

Write to Adriano Marchese at adriano.marchese@wsj.com

(END) Dow Jones Newswires

June 08, 2026 06:38 ET (10:38 GMT)

Copyright (c) 2026 Dow Jones & Company, Inc.

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