This article was automatically generated by Dow Jones using technology from Automated Insights.

International stocks trading in New York closed lower on Wednesday, as the S&P/BNY Mellon index of American depositary receipts declined 1.3% to 273.80.

The European index dropped 0.9% to 238.99. The Asian index fell 1.6% to 370.64. The Latin American index fell 1.6% to 275.72, while the emerging-markets index declined 1.7% to 617.77.

SaverOne 2014 Ltd., based in Israel, posted the largest decline, cratering 22% to $2.19, followed by shares of Netherlands's trivago N.V., which tumbled 17% to $5.26. Shares of Australia-based Kazia Therapeutics Ltd. tumbled 12% to $9.60.

China's VisionSys AI Inc. was the biggest leader during the session, soaring 84% to $3.64, and China-based Lixiang Education Holding Co. Ltd. surged 16% to $1.59. CL Workshop Group Ltd., which is based in Macau, rounded out the top three leaders on Wednesday, with shares jumping 12% to $1.41.

Data source: Dow Jones Market Data, FactSet