This article was automatically generated by Barrons.com using technology from Automated Insights.

With U.S. stock markets set to open in two hours, Vaxcyte Inc. $(PCVX)$ was up 54.1% in pre-market trading, and PTC Inc. (PTC) was up 36.2%.

Bio-Rad Laboratories Inc. Cl A (BIO), XP Inc. Cl A (XP), and Nu Holdings Ltd. Cl A (NU) were all posting gains of at least 11%. In early trading, Watts Water Technologies Inc. Cl A (WTS) and Westlake Corp. $(WLK)$ had posted declines, falling 13.0% and 11.2%, respectively.

Meanwhile S&P 500 futures were down 0.07%, with futures for the Dow Jones Industrial Average falling 0.06%. The Cboe Volatility Index futures were down 1.93%.

In commodities news, Brent crude oil futures were up 0.12%, while gold futures were up 0.65%. Bitcoin climbed 0.68% to $86,005.

The 10-Year Treasury yield slipped to 5.262%.

In the previous regular trading session, the S&P 500 and the Dow were up 0.73% and 0.49%, respectively. In Asia overnight, Japan's NIKKEI 225 Index was up 2.40%.

In afternoon trading, stocks in Europe are up, with the STOXX Europe 600 Index rising 0.32% and the FTSE 100 Index climbing 0.29% from the previous close.

U.S. stock markets open for trading at 9:30 a.m. ET.

Data source: Dow Jones Market Data, FactSet. Data compiled October 05, 2026.