European equities traded in the US as American depositary receipts were little changed around 1,893.13 on the S&P Europe Select ADR Index late Wednesday morning.

From continental Europe, the gainers were led by biopharmaceutical companies Cellectis (CLLS) and DBV Technologies (DBVT), which advanced 17% and 3.2% respectively. They were followed by healthcare tech firm Royal Philips (PHG) and medical device maker EDAP TMS (FOCL), which increased 2.2% and 1.7% respectively.

The decliners from continental Europe were led by 3D printer company Materialise (MTLS) and lender Banco Santander (SAN), which dropped 22% and 5% respectively. They were followed by consumer goods company Unilever (UL), which lost 1.7%.

The gainers from the UK and Ireland were led by Amarin (AMRN) and Biodexa Pharmaceuticals (BDRX), which rose 5.9% and 5.5% respectively. They were followed by Akari Therapeutics (AKTX) and Autolus Therapeutics (AUTL), which were up 5.1% and 1.6% respectively.

The decliners from the UK and Ireland were led by pharmaceutical company GSK (GSK) and biopharmaceutical firm NuCana (NCNA), which fell 3.3% and 2.7% respectively. They were followed by software firm Endava (DAVA) and mining firm BHP Group (BHP), which were off 2% and 1.8% respectively.