智通财经APP获悉，荣昌生物(09995)涨超7%，截至发稿，涨7.25%，报109.4港元，成交额3.57亿港元。
消息面上，9月28日，CDE官网显示，荣昌生物泰它西普拟纳入优先审评品种，用于治疗具有进展风险的原发性免疫球蛋白 A(IgA)肾病成人患者，显著降低蛋白尿水平。此前8月27日，荣昌生物宣布泰它西普治疗lgA肾病的国内III期研究达成A阶段的主要终点。研究结果显示，与安慰剂组相比，泰它西普组患者在治疗39周时24小时尿蛋白肌酐比值(UPCR)降低了55%。
据了解，泰它西普是目前唯一可同时抑制B淋巴细胞刺激因子(BLyS)和增殖诱导配体(APRIL)的药物，而这两种细胞因子在IgA肾病患者中的水平显著高于正常人群，是疾病发生的关键驱动因素。通过抑制这两种因子，泰它西普可减少B细胞增殖、降低浆细胞数量及异常免疫球蛋白生成，从源头阻断免疫复合物沉积，减轻肾脏免疫炎症反应。
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