NextCure and Simcere Zaiming Expand Phase 1 Trial of SIM0505 (CDH6 ADC) into U.S.; First American Patient Dosed

Reuters

Oct 16

NextCure and Simcere Zaiming Expand Phase 1 Trial of SIM0505 (CDH6 ADC) into U.S.; First American Patient Dosed

NextCure Inc. and Simcere Zaiming have announced the expansion of the ongoing Phase 1 clinical trial of SIM0505, a novel antibody drug conjugate targeting cadherin-6 (CDH6), into the United States. The first U.S. patient has been dosed at a mid-tier dose level where multiple responses have previously been observed. The multi-regional trial, which began in China, is evaluating safety, tolerability, pharmacokinetics, and efficacy in patients with advanced solid tumors. NextCure expects to present proof-of-concept clinical data in the first half of 2026. No clinical results have been presented yet.

Disclaimer: This news brief was created by Public Technologies (PUBT) using generative artificial intelligence. While PUBT strives to provide accurate and timely information, this AI-generated content is for informational purposes only and should not be interpreted as financial, investment, or legal advice. NextCure Inc. published the original content used to generate this news brief via GlobeNewswire (Ref. ID: GNW9546244-en) on October 16, 2025, and is solely responsible for the information contained therein.

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