Gain Therapeutics Reports First Reduction of GluSph in Parkinson’s Patients with GT-02287 in Phase 1b Trial

Reuters

Dec 18, 2025

Gain <a href="https://laohu8.com/S/LENZ">Therapeutics</a> Reports First Reduction of GluSph in Parkinson’s Patients with GT-02287 in Phase 1b Trial

Gain Therapeutics Inc. announced positive results from its Phase 1b clinical study of GT-02287 in people with Parkinson’s disease. The study demonstrated central nervous system target engagement, with a reduction in the GCase substrate glucosylsphingosine (GluSph) in cerebrospinal fluid, a prespecified exploratory endpoint. This reduction, observed for the first time following administration of a GCase modulator to Parkinson’s disease patients, suggests increased GCase activity in the brain. The results will be discussed during a virtual KOL event scheduled for January 6, 2026.

Disclaimer: This news brief was created by Public Technologies (PUBT) using generative artificial intelligence. While PUBT strives to provide accurate and timely information, this AI-generated content is for informational purposes only and should not be interpreted as financial, investment, or legal advice. Gain Therapeutics Inc. published the original content used to generate this news brief via GlobeNewswire (Ref. ID: GNW9604240-en) on December 18, 2025, and is solely responsible for the information contained therein.

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The study demonstrated central nervous system target engagement, with a reduction in the GCase substrate glucosylsphingosine (GluSph) in cerebrospinal fluid, a prespecified exploratory endpoint. This reduction, observed for the first time following administration of a GCase modulator to Parkinson’s disease patients, suggests increased GCase activity in the brain. The results will be discussed during a virtual KOL event scheduled for January 6, 2026.\n      \n\nDisclaimer: This news brief was created by Public Technologies (PUBT) using generative artificial intelligence. While PUBT strives to provide accurate and timely information, this AI-generated content is for informational purposes only and should not be interpreted as financial, investment, or legal advice. Gain Therapeutics Inc. published the original content used to generate this news brief via GlobeNewswire (Ref. ID: GNW9604240-en) on December 18, 2025, and is solely responsible for the information contained therein.","kind":"highlight","is_publish_news":true,"is_publish_highlight":false,"is_publish_live":false,"is_publish_wemedia":null,"editions":null,"column":"","sentiment":"1","news_tag":"dataReport,express","news_rank":0,"symbols":[],"gpt_button":0,"need_auth":false,"code":"91000000","status":"200"}}}