ENG/中
老虎證券
市场
行情
24/7新闻
产品
Cash Boost账户
期权
A股通
港股
固定票息票据
美股
ETF
基金超市
美国国债
新加坡股
期货
Tiger BOSS Debit Card
老虎钱袋子
功能
经纪人
定投
CPF/SRS 投资
专栏
美股碎股
TigerAI
费用
综合账户
股票与ETF
期权、窝轮与牛熊证
期货
债券
基金超市
Cash Boost
股票与ETF
融资利率
活动
帮助
账户操作
如何开户
开户文件
账户类型
资金与转仓
入金
DDA快捷入金
出金
转入股票
转出股票
货币兑换
产品与交易
可交易产品
订单类型
交易规则
申报
融资融券
保证金与杠杆
风险管理
做空风险
基金超市
基金开户与交易
Cash Boost账户
Cash Boost 账户FAQ
如何开通 Cash Boost 账户
如何用Cash Boost 账户交易
如何绑定CDP证券账户
Tiger Boss Debit Card
常见问题
费用说明
如何充值
如何使用我的Debit card
账单报表
账单报表
股息（分红）
机构
Tiger Fund Management
机构服务
财富及资产管理人
自营交易机构
介绍经纪商
三方服务商
老虎API平台
登入
立即註冊
Toggle
美股
詳情
本頁面由Tiger Trade Technology Pte. Ltd.提供服務
Ionis Pharmaceuticals, Inc
75.26
-1.5600
-2.03%
成交量：
187.39萬
成交額：
1.41億
市值：
124.32億
市盈率：
-31.62
高：
76.53
開：
76.42
低：
73.91
收：
76.82
52周最高：
86.74
52周最低：
27.90
股本：
1.65億
流通股本：
1.64億
量比：
1.28
換手率：
1.14%
股息：
- -
股息率：
- -
每股收益(TTM):
-2.3800
每股收益(LYR):
-2.3812
淨資產收益率：
-70.80%
總資產收益率：
-7.31%
市淨率：
25.42
市盈率(LYR):
-31.61
資料載入中...
總覽
公司
新聞資訊
公告
2021/05/05
季度報告
10-Q - Quarterly report [Sections 13 or 15(d)]
2021/05/05
重要事件披露
8-K - Current report
2021/04/13
重要事件披露
8-K - Current report
2021/04/06
重要事件披露
8-K - Current report
2021/03/29
重要事件披露
8-K - Current report
2021/03/23
重要事件披露
8-K - Current report
2021/02/24
年度報告
10-K - Annual report [Section 13 and 15(d), not S-K Item 405]
2021/02/24
重要事件披露
8-K - Current report
2021/02/16
超過5%披露
SC 13G - Statement of acquisition of beneficial ownership by individuals
2021/02/12
超過5%披露
SC 13G/A [Amend] - Statement of acquisition of beneficial ownership by individuals
2021/02/10
超過5%披露
SC 13G/A [Amend] - Statement of acquisition of beneficial ownership by individuals
2021/02/09
超過5%披露
SC 13G/A [Amend] - Statement of acquisition of beneficial ownership by individuals
2021/02/08
超過5%披露
SC 13G/A [Amend] - Statement of acquisition of beneficial ownership by individuals
2021/02/05
超過5%披露
SC 13G/A [Amend] - Statement of acquisition of beneficial ownership by individuals
2021/01/14
SEC問詢函
CORRESP [Cover] - Correspondence
2020/12/31
員工持股計劃
S-8 - Securities to be offered to employees in employee benefit plans
2020/12/18
重要事件披露
8-K - Current report
2020/12/09
重要事件披露
8-K - Current report
2020/11/04
季度報告
10-Q - Quarterly report [Sections 13 or 15(d)]
2020/11/04
重要事件披露
8-K - Current report
更多
{"basename":"/hant","ssrTDKData":{"titleTemplate":"%s - 老虎證券","title":"老虎证券全球投资理财平台| 一站式投资美股新股港股A股","description":"老虎证券助您一站式投资美股，新股，港股，A股等全球金融理财产品。新加坡华人最信赖的在线投资平台，现在加入即享低费用，24/5 无时差炒美股投资理财！","keywords":"老虎證券,老虎證券開戶,老虎券商,老虎證券官網,老虎證券app,tigertrade老虎證券,股票,炒股,新加坡股票交易平臺,投資,投資理財","social":{"ogDescription":"老虎证券助您一站式投资美股，新股，港股，A股等全球金融理财产品。新加坡华人最信赖的在线投资平台，现在加入即享低费用，24/5 无时差炒美股投资理财！","ogImage":"https://c1.itigergrowtha.com/portal5/static/media/og-logo.be62fbe1.png","ogUrl":"https://www.itiger.com/hant/stock/IONS/filings?page=15"},"companyName":"老虎證券"},"pageData":{"isMobile":false,"isTiger":false,"isTTM":true,"region":"SGP","license":"TBSG","edition":"fundamental","symbol":"IONS","isAnalysisPage":false},"__swrFallback__":{"@#url:\"https://hq.skytigris.cn/stock_info/detail/global\",params:#delay:false,,method:\"POST\",data:#items:@#symbol:\"IONS\",,,,,undefined,":{"symbol":"IONS","market":"US","secType":"STK","nameCN":"Ionis Pharmaceuticals, Inc","latestPrice":75.26,"timestamp":1776369600000,"preClose":76.82,"halted":0,"volume":1873899,"delay":0,"changeRate":-0.02030721166362911,"floatShares":164000000,"shares":165192011,"eps":-2.38,"marketStatus":"盤前交易","change":-1.56,"latestTime":"04-17 07:59:34 EDT","open":76.42,"high":76.525,"low":73.905,"amount":140635239.21747002,"amplitude":0.034106,"askPrice":87.11,"askSize":100,"bidPrice":72.85,"bidSize":43,"shortable":3,"etf":0,"ttmEps":-2.38,"tradingStatus":1,"nextMarketStatus":{"tag":"開盤","tradingStatus":2,"beginTime":1776432600000},"marketStatusCode":1,"adr":0,"adrRate":0,"exchange":"NASDAQ","adjPreClose":75.26,"postHourTrading":{"tag":"盘后","latestPrice":75.0343,"preClose":75.26,"latestTime":"17:14 EDT","volume":153429,"amount":11545116.8733,"timestamp":1776374060831,"change":-0.2257,"changeRate":-0.002999,"amplitude":0.002999},"volumeRatio":1.2804971547606827,"impliedVol":0.3772,"impliedVolPercentile":0.1566},"@#url:\"https://hq.skytigris.cn/stock_info/fundamental/all\",params:#delay:false,,method:\"POST\",data:#items:@#symbol:\"IONS\",,,,,undefined,":{"symbol":"IONS","floatShares":164000000,"roa":"-7.31%","roe":"-70.80%","lyrEps":-2.38125,"volumeRatio":1.2804971547606827,"shares":165192011,"dividePrice":0,"high":76.525,"amplitude":0.034106,"preClose":76.82,"low":73.905,"week52Low":27.9,"pbRate":"25.42","psRate":"13.17","week52High":86.74,"institutionHeld":0.9791,"latestPrice":75.26,"committee":-0.398601,"eps":-2.38,"divideRate":0,"volume":1873899,"delay":0,"ttmEps":-2.38,"open":76.42,"prevYearClose":79.11,"prevWeekClose":75.17,"prevMonthClose":75.09,"prevQuarterClose":75.09,"fiveDayClose":76.43,"twentyDayClose":71.67,"sixtyDayClose":77.53,"earningDate":1777392000000,"earningTime":"盘前"},"@#url:\"https://hq.skytigris.cn/fundamental/corporate_actions/details/IONS\",params:#limit:5,,,undefined,":[{"date":"2026-04-29","symbol":"IONS","type":"earning","reportTimeType":"pre","market":"US","fiscalQuarterEnding":"2026/03","expectedEps":-0.86,"defaultRemindTime":1777449600000,"name":null,"time":"盤前","dateTimestamp":1777435200000,"actualEps":null},{"market":"US","date":"2026-02-25","symbol":"IONS","fiscalQuarterEnding":"2025/12","expectedEps":-1.31,"name":null,"time":"盤前","type":"earning","dateTimestamp":1771995600000,"reportTimeType":"pre","actualEps":-1.41},{"market":"US","date":"2025-10-29","symbol":"IONS","fiscalQuarterEnding":"2025/09","expectedEps":-1.23,"name":null,"time":"盤前","type":"earning","dateTimestamp":1761710400000,"reportTimeType":"pre","actualEps":-0.8},{"market":"US","date":"2025-07-30","symbol":"IONS","fiscalQuarterEnding":"2025/06","expectedEps":-0.11,"name":null,"time":"盤前","type":"earning","dateTimestamp":1753848000000,"reportTimeType":"pre","actualEps":0.7},{"market":"US","date":"2025-04-30","symbol":"IONS","fiscalQuarterEnding":"2025/03","expectedEps":-1.16,"name":null,"time":"盤前","type":"earning","dateTimestamp":1745985600000,"reportTimeType":"pre","actualEps":-0.93}],"@#url:\"https://hq.skytigris.cn/fundamental/dividend/history\",params:#symbol:\"IONS\",market:\"US\",,,undefined,":[],"@#url:\"https://hq.skytigris.cn/fundamental/estimate/recommendation\",params:#symbol:\"IONS\",market:\"US\",delay:false,,,undefined,":{"strongBuy":0.2917,"buy":0.4583,"hold":0.25,"sell":0,"strongSell":0,"meanLabel":"BUY","meanPercent":0.4583,"analysts":24,"updateTime":1775793600000},"@#url:\"https://hq.skytigris.cn/value_analysis/stock/IONS\",params:#withQuantilePoint:true,period:\"5year\",factor:\"peRate\",delay:false,algorithm:1,,,undefined,":{"brief":{"id":"IONS","date":"2026-04-16","current":-31.621849,"percent":0.248578,"low":-1664.931905,"twenty":-46.808807,"median":-17.348546,"eighty":-10.419492,"high":882.260453,"avg":-63.508601,"sd":366.123368,"marketCap":12690050285},"quantilePoints":[{"date":"2021-04-23","current":-13.542136,"twenty":-113.715351,"median":24.094838,"eighty":153.903551,"marketCap":6016269938},{"date":"2021-04-30","current":-13.583375,"twenty":-113.715351,"median":24.094838,"eighty":153.903551,"marketCap":6034590741},{"date":"2021-05-07","current":-10.416072,"twenty":-112.558018,"median":24.094838,"eighty":153.903551,"marketCap":5150789043},{"date":"2021-05-14","current":-10.900673,"twenty":-110.935774,"median":24.094838,"eighty":153.903551,"marketCap":5390426190},{"date":"2021-05-21","current":-10.322002,"twenty":-108.007821,"median":24.094838,"eighty":153.903551,"marketCap":5104271243},{"date":"2021-05-28","current":-10.618464,"twenty":-103.625784,"median":24.094838,"eighty":153.903551,"marketCap":5250872793},{"date":"2021-06-04","current":-9.845953,"twenty":-51.294186,"median":24.094838,"eighty":153.903551,"marketCap":4868862987},{"date":"2021-06-11","current":-10.812304,"twenty":-50.272801,"median":24.094838,"eighty":153.903551,"marketCap":5346727652},{"date":"2021-06-18","current":-10.772396,"twenty":-49.437626,"median":24.094838,"eighty":153.903551,"marketCap":5326992828},{"date":"2021-06-25","current":-11.097364,"twenty":-48.412553,"median":24.094838,"eighty":153.903551,"marketCap":5487690680},{"date":"2021-07-02","current":-11.379572,"twenty":-48.099131,"median":24.094838,"eighty":153.903551,"marketCap":5627244077},{"date":"2021-07-09","current":-11.08026,"twenty":-47.813364,"median":24.094838,"eighty":153.903551,"marketCap":5479232898},{"date":"2021-07-16","current":-10.418922,"twenty":-46.987407,"median":24.094838,"eighty":153.903551,"marketCap":5152198673},{"date":"2021-07-23","current":-10.84081,"twenty":-46.428779,"median":24.094838,"eighty":153.903551,"marketCap":5360823954},{"date":"2021-07-30","current":-10.587107,"twenty":-45.619415,"median":24.094838,"eighty":153.903551,"marketCap":5235366859},{"date":"2021-08-06","current":-9.961983,"twenty":-44.489253,"median":24.094838,"eighty":153.903551,"marketCap":5476530682},{"date":"2021-08-13","current":-10.187925,"twenty":-43.823694,"median":23.887124,"eighty":151.247358,"marketCap":5600740656},{"date":"2021-08-20","current":-10.080089,"twenty":-43.823694,"median":23.605478,"eighty":146.702778,"marketCap":5541458623},{"date":"2021-08-27","current":-10.175088,"twenty":-43.823694,"median":23.306229,"eighty":141.027241,"marketCap":5593683271},{"date":"2021-09-03","current":-10.146845,"twenty":-43.823694,"median":22.806307,"eighty":135.009304,"marketCap":5578157024},{"date":"2021-09-10","current":-9.266185,"twenty":-43.823694,"median":22.273726,"eighty":92.336284,"marketCap":5094020420},{"date":"2021-09-17","current":-9.553748,"twenty":-43.823694,"median":22.105712,"eighty":90.484478,"marketCap":5252105842},{"date":"2021-09-24","current":-9.294428,"twenty":-43.823694,"median":21.894477,"eighty":89.822908,"marketCap":5109546667},{"date":"2021-10-01","current":-8.61917,"twenty":-43.823694,"median":21.739571,"eighty":88.160122,"marketCap":4738328221},{"date":"2021-10-08","current":-8.752681,"twenty":-43.823694,"median":21.475528,"eighty":87.371554,"marketCap":4811725024},{"date":"2021-10-15","current":-9.012001,"twenty":-43.823694,"median":21.145012,"eighty":86.264015,"marketCap":4954284199},{"date":"2021-10-22","current":-7.815535,"twenty":-43.823694,"median":21.004285,"eighty":84.663252,"marketCap":4296535927},{"date":"2021-10-29","current":-8.182691,"twenty":-43.823694,"median":20.82218,"eighty":83.19244,"marketCap":4498377135},{"date":"2021-11-05","current":-7.827936,"twenty":-43.823694,"median":20.669316,"eighty":82.070133,"marketCap":4757365405},{"date":"2021-11-12","current":-7.595584,"twenty":-43.823694,"median":20.616507,"eighty":76.079084,"marketCap":4616155390},{"date":"2021-11-19","current":-7.432938,"twenty":-43.823694,"median":20.366546,"eighty":75.49578,"marketCap":4517308379},{"date":"2021-11-26","current":-6.749823,"twenty":-43.823694,"median":20.294106,"eighty":74.547727,"marketCap":4102150935},{"date":"2021-12-03","current":-6.131767,"twenty":-43.823694,"median":20.173015,"eighty":74.030875,"marketCap":3726532295},{"date":"2021-12-10","current":-6.847411,"twenty":-43.823694,"median":20.114106,"eighty":72.607318,"marketCap":4161459142},{"date":"2021-12-17","current":-7.542143,"twenty":-43.823694,"median":20.025743,"eighty":70.436541,"marketCap":4583677086},{"date":"2021-12-23","current":-7.600231,"twenty":-43.823694,"median":19.891562,"eighty":60.214071,"marketCap":4618979590},{"date":"2021-12-31","current":-7.070469,"twenty":-43.823694,"median":19.796653,"eighty":53.012098,"marketCap":4297020756},{"date":"2022-01-07","current":-7.058851,"twenty":-43.611673,"median":19.749198,"eighty":51.923862,"marketCap":4289960255},{"date":"2022-01-14","current":-7.686201,"twenty":-43.611673,"median":19.64938,"eighty":51.147099,"marketCap":4671227296},{"date":"2022-01-21","current":-6.942675,"twenty":-43.611673,"median":19.61175,"eighty":50.934296,"marketCap":4219355248},{"date":"2022-01-28","current":-7.360909,"twenty":-43.611673,"median":19.468798,"eighty":50.847883,"marketCap":4473533275},{"date":"2022-02-04","current":-7.319085,"twenty":-43.611673,"median":19.28882,"eighty":50.5876,"marketCap":4448115472},{"date":"2022-02-11","current":-7.639731,"twenty":-43.611673,"median":19.164904,"eighty":50.143461,"marketCap":4642985293},{"date":"2022-02-18","current":-7.497996,"twenty":-43.611673,"median":18.965356,"eighty":49.908881,"marketCap":4556847184},{"date":"2022-02-25","current":-157.459445,"twenty":-44.533501,"median":18.77393,"eighty":49.713145,"marketCap":4502867744},{"date":"2022-03-04","current":-160.035874,"twenty":-45.829592,"median":18.155386,"eighty":49.32903,"marketCap":4576545882},{"date":"2022-03-11","current":-159.49086,"twenty":-46.633425,"median":-6.144547,"eighty":48.69515,"marketCap":4560960122},{"date":"2022-03-18","current":-174.652153,"twenty":-47.12015,"median":-6.881102,"eighty":48.427938,"marketCap":4994527626},{"date":"2022-03-25","current":-181.687786,"twenty":-47.927671,"median":-7.000763,"eighty":48.265452,"marketCap":5195725619},{"date":"2022-04-01","current":-192.736702,"twenty":-48.230031,"median":-7.040263,"eighty":47.833218,"marketCap":5511691480},{"date":"2022-04-08","current":-198.781401,"twenty":-48.689101,"median":-7.082087,"eighty":47.228668,"marketCap":5684551727},{"date":"2022-04-14","current":-202.992871,"twenty":-49.716018,"median":-7.119262,"eighty":46.918857,"marketCap":5804987145},{"date":"2022-04-22","current":-206.852389,"twenty":-50.435043,"median":-7.237762,"eighty":46.570634,"marketCap":5915357781},{"date":"2022-04-29","current":-182.216483,"twenty":-51.591015,"median":-7.300497,"eighty":46.245658,"marketCap":5210844764},{"date":"2022-05-06","current":-1322.183946,"twenty":-128.214398,"median":-7.341159,"eighty":45.925265,"marketCap":5147262100},{"date":"2022-05-13","current":-1314.170709,"twenty":-130.326929,"median":-7.37485,"eighty":45.90793,"marketCap":5116066572},{"date":"2022-05-20","current":-1438.375868,"twenty":-130.86667,"median":-7.37485,"eighty":45.90793,"marketCap":5599597254},{"date":"2022-05-27","current":-1370.6276,"twenty":-132.625178,"median":-7.37485,"eighty":45.90793,"marketCap":5335853246},{"date":"2022-06-03","current":-1316.720376,"twenty":-134.128325,"median":-7.37485,"eighty":45.90793,"marketCap":5125992422},{"date":"2022-06-10","current":-1266.091293,"twenty":-137.45382,"median":-7.37485,"eighty":45.90793,"marketCap":4928893405},{"date":"2022-06-17","current":-1284.303193,"twenty":-139.005646,"median":-7.37485,"eighty":45.90793,"marketCap":4999792332},{"date":"2022-06-24","current":-1429.634156,"twenty":-139.862338,"median":-7.360909,"eighty":45.909339,"marketCap":5565565769},{"date":"2022-07-01","current":-1386.289834,"twenty":-141.353878,"median":-7.360909,"eighty":45.909339,"marketCap":5396826323},{"date":"2022-07-08","current":-1353.144176,"twenty":-142.456573,"median":-7.360909,"eighty":45.909339,"marketCap":5267790276},{"date":"2022-07-15","current":-1431.819584,"twenty":-143.808127,"median":-7.360909,"eighty":45.909339,"marketCap":5574073640},{"date":"2022-07-22","current":-1387.746786,"twenty":-144.656772,"median":-7.360909,"eighty":45.909339,"marketCap":5402498237},{"date":"2022-07-29","current":-1368.077934,"twenty":-146.022974,"median":-7.360909,"eighty":45.909339,"marketCap":5325927396},{"date":"2022-08-05","current":-1664.567667,"twenty":-147.819198,"median":-7.360909,"eighty":45.909339,"marketCap":6480161927},{"date":"2022-08-12","current":-222.342663,"twenty":-148.698169,"median":-7.360909,"eighty":45.909339,"marketCap":6259613005},{"date":"2022-08-19","current":-221.838485,"twenty":-149.407406,"median":-7.360909,"eighty":45.909339,"marketCap":6245418872},{"date":"2022-08-26","current":-213.519542,"twenty":-149.883165,"median":-7.360909,"eighty":45.909339,"marketCap":6011215664},{"date":"2022-09-02","current":-218.006729,"twenty":-150.165357,"median":-7.360909,"eighty":45.909339,"marketCap":6137543455},{"date":"2022-09-09","current":-236.157151,"twenty":-151.092649,"median":-7.360909,"eighty":45.909339,"marketCap":6648532271},{"date":"2022-09-16","current":-233.585841,"twenty":-153.529951,"median":-7.360909,"eighty":45.909339,"marketCap":6576142189},{"date":"2022-09-23","current":-217.956312,"twenty":-156.46647,"median":-7.360909,"eighty":45.909339,"marketCap":6136124041},{"date":"2022-09-30","current":-222.998095,"twenty":-157.969129,"median":-7.360909,"eighty":45.909339,"marketCap":6278065379},{"date":"2022-10-07","current":-231.569128,"twenty":-159.577078,"median":-7.360909,"eighty":45.909339,"marketCap":6519365654},{"date":"2022-10-14","current":-233.737095,"twenty":-160.082841,"median":-7.360909,"eighty":45.909339,"marketCap":6580400429},{"date":"2022-10-21","current":-226.62818,"twenty":-160.43291,"median":-7.360909,"eighty":45.909339,"marketCap":6380263143},{"date":"2022-10-28","current":-224.913973,"twenty":-161.94987,"median":-7.360909,"eighty":45.909339,"marketCap":6332003088},{"date":"2022-11-04","current":-209.486115,"twenty":-162.370971,"median":-7.360909,"eighty":45.909339,"marketCap":5897662593},{"date":"2022-11-11","current":839.185498,"twenty":-162.756411,"median":-7.319085,"eighty":46.031035,"marketCap":6143677032},{"date":"2022-11-18","current":836.080997,"twenty":-162.756411,"median":-7.284232,"eighty":46.34415,"marketCap":6120948978},{"date":"2022-11-25","current":806.394204,"twenty":-162.756411,"median":-7.219174,"eighty":46.64061,"marketCap":5903611964},{"date":"2022-12-02","current":782.334319,"twenty":-162.756411,"median":-7.102998,"eighty":47.141347,"marketCap":5727469547},{"date":"2022-12-09","current":727.617484,"twenty":-162.756411,"median":-7.058851,"eighty":47.387939,"marketCap":5326887600},{"date":"2022-12-16","current":750.125118,"twenty":-162.756411,"median":-7.014704,"eighty":48.047842,"marketCap":5491665989},{"date":"2022-12-23","current":740.423552,"twenty":-162.756411,"median":-6.972881,"eighty":48.293594,"marketCap":5420640821},{"date":"2022-12-30","current":732.85633,"twenty":-162.756411,"median":-6.749823,"eighty":48.503303,"marketCap":5365241190},{"date":"2023-01-06","current":786.214945,"twenty":-162.756411,"median":-6.749823,"eighty":48.503303,"marketCap":5755879614},{"date":"2023-01-13","current":773.214846,"twenty":-162.756411,"median":-6.749823,"eighty":48.503303,"marketCap":5660705889},{"date":"2023-01-20","current":790.871697,"twenty":-162.756411,"median":-6.749823,"eighty":48.503303,"marketCap":5789971695},{"date":"2023-01-27","current":776.513379,"twenty":-162.756411,"median":-6.749823,"eighty":48.503303,"marketCap":5684854446},{"date":"2023-02-03","current":793.976198,"twenty":-162.756411,"median":-6.749823,"eighty":48.503303,"marketCap":5812699749},{"date":"2023-02-10","current":756.722183,"twenty":-162.756411,"median":-6.749823,"eighty":48.503303,"marketCap":5539963104},{"date":"2023-02-17","current":748.96093,"twenty":-162.756411,"median":-6.749823,"eighty":48.503303,"marketCap":5483142969},{"date":"2023-02-24","current":-18.915876,"twenty":-162.756411,"median":-6.942675,"eighty":48.318169,"marketCap":5102028010},{"date":"2023-03-03","current":-19.398181,"twenty":-162.756411,"median":-7.010057,"eighty":48.167441,"marketCap":5232116143},{"date":"2023-03-10","current":-17.998968,"twenty":-162.756411,"median":-7.047233,"eighty":47.522459,"marketCap":4854717602},{"date":"2023-03-17","current":-18.645574,"twenty":-162.756411,"median":-7.096027,"eighty":47.151665,"marketCap":5029121473},{"date":"2023-03-24","current":-17.993668,"twenty":-162.756411,"median":-7.188968,"eighty":46.719576,"marketCap":4853288062},{"date":"2023-03-31","current":-18.942377,"twenty":-162.739653,"median":-7.283071,"eighty":46.447558,"marketCap":5109175709},{"date":"2023-04-06","current":-19.392881,"twenty":-162.739653,"median":-7.309791,"eighty":46.139197,"marketCap":5230686603},{"date":"2023-04-14","current":-19.906986,"twenty":-162.756411,"median":-7.388791,"eighty":45.881909,"marketCap":5369351977},{"date":"2023-04-21","current":-19.158378,"twenty":-162.756411,"median":-7.484055,"eighty":45.586713,"marketCap":5167435947},{"date":"2023-04-28","current":-18.691747,"twenty":-162.756411,"median":-7.542143,"eighty":45.238708,"marketCap":5041575343},{"date":"2023-05-05","current":-15.654507,"twenty":-162.722895,"median":-7.581643,"eighty":45.096531,"marketCap":5148454369},{"date":"2023-05-12","current":-15.484823,"twenty":-162.005118,"median":-7.581643,"eighty":45.096531,"marketCap":5092648444},{"date":"2023-05-19","current":-15.937315,"twenty":-160.611822,"median":-7.581643,"eighty":45.096531,"marketCap":5241464245},{"date":"2023-05-26","current":-17.042442,"twenty":-160.205418,"median":-7.581643,"eighty":45.096531,"marketCap":5604918222},{"date":"2023-06-02","current":-18.682728,"twenty":-159.773437,"median":-7.581643,"eighty":45.096531,"marketCap":6144375503},{"date":"2023-06-09","current":-18.121463,"twenty":-159.192484,"median":-7.581643,"eighty":45.096531,"marketCap":5959786673},{"date":"2023-06-16","current":-18.138866,"twenty":-156.985977,"median":-7.581643,"eighty":45.096531,"marketCap":5965510357},{"date":"2023-06-23","current":-17.925673,"twenty":-155.435521,"median":-7.578157,"eighty":45.109315,"marketCap":5895395220},{"date":"2023-06-30","current":-17.886515,"twenty":-151.740635,"median":-7.574672,"eighty":45.122099,"marketCap":5882516929},{"date":"2023-07-07","current":-18.169323,"twenty":-150.657265,"median":-7.574672,"eighty":45.122099,"marketCap":5975526805},{"date":"2023-07-14","current":-18.560903,"twenty":-150.083568,"median":-7.574672,"eighty":45.122099,"marketCap":6104309711},{"date":"2023-07-21","current":-17.821251,"twenty":-149.641501,"median":-7.574672,"eighty":45.122099,"marketCap":5861053112},{"date":"2023-07-28","current":-16.750932,"twenty":-149.090615,"median":-7.574672,"eighty":45.122099,"marketCap":5509046504},{"date":"2023-08-04","current":-17.151214,"twenty":-148.303568,"median":-7.574672,"eighty":45.122099,"marketCap":5640691252},{"date":"2023-08-11","current":-18.467972,"twenty":-148.00823,"median":-7.574672,"eighty":45.122099,"marketCap":5707249602},{"date":"2023-08-18","current":-18.147959,"twenty":-147.735407,"median":-7.574672,"eighty":45.122099,"marketCap":5608354519},{"date":"2023-08-25","current":-18.463334,"twenty":-145.579013,"median":-7.574672,"eighty":45.122099,"marketCap":5705816340},{"date":"2023-09-01","current":-18.676675,"twenty":-145.219114,"median":-7.574672,"eighty":45.122099,"marketCap":5771746396},{"date":"2023-09-08","current":-18.727692,"twenty":-145.219114,"median":-7.574672,"eighty":45.122099,"marketCap":5787512279},{"date":"2023-09-15","current":-20.239635,"twenty":-145.219114,"median":-7.574672,"eighty":45.122099,"marketCap":6254755717},{"date":"2023-09-22","current":-19.701643,"twenty":-144.797122,"median":-7.574672,"eighty":45.122099,"marketCap":6088497315},{"date":"2023-09-29","current":-21.454756,"twenty":-143.400598,"median":-7.574672,"eighty":45.122099,"marketCap":6630270382},{"date":"2023-10-06","current":-21.728389,"twenty":-143.032342,"median":-7.574672,"eighty":45.122099,"marketCap":6714832844},{"date":"2023-10-13","current":-21.38055,"twenty":-143.032342,"median":-7.574672,"eighty":45.122099,"marketCap":6607338188},{"date":"2023-10-20","current":-21.593891,"twenty":-143.032342,"median":-7.574672,"eighty":45.122099,"marketCap":6673268244},{"date":"2023-10-27","current":-21.16257,"twenty":-143.300049,"median":-7.55957,"eighty":45.146419,"marketCap":6539974871},{"date":"2023-11-03","current":-15.297336,"twenty":-140.032184,"median":-7.55957,"eighty":45.146419,"marketCap":6267655075},{"date":"2023-11-10","current":-16.577399,"twenty":-22.395314,"median":-7.55957,"eighty":45.146419,"marketCap":6787665949},{"date":"2023-11-17","current":-17.008391,"twenty":-21.672735,"median":-7.55957,"eighty":45.146419,"marketCap":6964136656},{"date":"2023-11-24","current":-17.460406,"twenty":-21.484438,"median":-7.55957,"eighty":45.146419,"marketCap":7149215689},{"date":"2023-12-01","current":-17.334262,"twenty":-21.2275,"median":-7.55957,"eighty":45.146419,"marketCap":7097565726},{"date":"2023-12-08","current":-17.334262,"twenty":-20.411236,"median":-7.572349,"eighty":45.140651,"marketCap":7097565726},{"date":"2023-12-15","current":-17.456902,"twenty":-20.127399,"median":-7.572349,"eighty":45.140651,"marketCap":7147780968},{"date":"2023-12-22","current":-17.208119,"twenty":-19.907658,"median":-7.572349,"eighty":45.140651,"marketCap":7045915764},{"date":"2023-12-29","current":-17.695174,"twenty":-19.76602,"median":-7.55957,"eighty":45.146419,"marketCap":7245342009},{"date":"2024-01-05","current":-18.038565,"twenty":-19.665059,"median":-7.54679,"eighty":45.152187,"marketCap":7385944686},{"date":"2024-01-12","current":-18.763892,"twenty":-19.458602,"median":-7.54679,"eighty":45.152187,"marketCap":7682931972},{"date":"2024-01-19","current":-17.747734,"twenty":-19.2678,"median":-7.544467,"eighty":45.157955,"marketCap":7266862827},{"date":"2024-01-26","current":-18.073605,"twenty":-19.134896,"median":-7.54679,"eighty":45.152187,"marketCap":7400291898},{"date":"2024-02-02","current":-17.859862,"twenty":-19.007278,"median":-7.54679,"eighty":45.152187,"marketCap":7312773905},{"date":"2024-02-09","current":-17.512966,"twenty":-18.941814,"median":-7.54679,"eighty":45.152187,"marketCap":7170736507},{"date":"2024-02-16","current":-15.866089,"twenty":-18.881956,"median":-7.54679,"eighty":45.152187,"marketCap":6496417548},{"date":"2024-02-23","current":-17.500434,"twenty":-18.811317,"median":-7.54679,"eighty":45.152187,"marketCap":6410164032},{"date":"2024-03-01","current":-17.989873,"twenty":-18.791838,"median":-7.578157,"eighty":45.146419,"marketCap":6589438742},{"date":"2024-03-08","current":-17.774998,"twenty":-18.791838,"median":-7.603716,"eighty":45.146419,"marketCap":6510732771},{"date":"2024-03-15","current":-16.784182,"twenty":-18.791838,"median":-7.673842,"eighty":45.146419,"marketCap":6147810797},{"date":"2024-03-22","current":-17.010995,"twenty":-18.791838,"median":-7.777023,"eighty":45.146419,"marketCap":6230889321},{"date":"2024-03-28","current":-17.771018,"twenty":-18.791838,"median":-7.81825,"eighty":45.146419,"marketCap":6509275254},{"date":"2024-04-05","current":-17.042828,"twenty":-18.796083,"median":-7.904612,"eighty":45.152187,"marketCap":6242549465},{"date":"2024-04-12","current":-16.911516,"twenty":-18.796083,"median":-8.182691,"eighty":45.152187,"marketCap":6194451372},{"date":"2024-04-19","current":-16.239034,"twenty":-18.796083,"median":-8.560117,"eighty":45.152187,"marketCap":5948130835},{"date":"2024-04-26","current":-16.659633,"twenty":-18.791838,"median":-8.646128,"eighty":45.146419,"marketCap":6102190447},{"date":"2024-05-03","current":-17.157352,"twenty":-18.791838,"median":-8.845112,"eighty":45.146419,"marketCap":6284497762},{"date":"2024-05-10","current":-14.961134,"twenty":-18.791838,"median":-9.293144,"eighty":45.146419,"marketCap":5756535778},{"date":"2024-05-17","current":-14.25989,"twenty":-18.791838,"median":-9.334225,"eighty":45.146419,"marketCap":5486720952},{"date":"2024-05-24","current":-14.40393,"twenty":-18.791838,"median":-9.552464,"eighty":45.146419,"marketCap":5542142376},{"date":"2024-05-31","current":-13.854306,"twenty":-18.791838,"median":-9.739892,"eighty":45.146419,"marketCap":5330665890},{"date":"2024-06-07","current":-15.112755,"twenty":-18.791838,"median":-9.90935,"eighty":45.146419,"marketCap":5814874119},{"date":"2024-06-14","current":-15.586568,"twenty":-18.796083,"median":-9.987659,"eighty":45.152187,"marketCap":5997181434},{"date":"2024-06-21","current":-15.469062,"twenty":-18.800329,"median":-10.068299,"eighty":45.157955,"marketCap":5951969220},{"date":"2024-06-28","current":-17.902568,"twenty":-18.809069,"median":-10.099656,"eighty":45.171414,"marketCap":6888299589},{"date":"2024-07-05","current":-17.284716,"twenty":-18.809069,"median":-10.146845,"eighty":45.171414,"marketCap":6650570851},{"date":"2024-07-12","current":-17.932892,"twenty":-18.809069,"median":-10.187925,"eighty":45.171414,"marketCap":6899967258},{"date":"2024-07-15","current":-18.194437,"twenty":-18.809069,"median":-10.208466,"eighty":45.171414,"marketCap":7000600896},{"date":"2024-08-02","current":-20.490271,"twenty":-18.868176,"median":-10.389456,"eighty":45.307924,"marketCap":7484809124},{"date":"2024-08-09","current":-18.992918,"twenty":-18.884076,"median":-10.451704,"eighty":45.307924,"marketCap":6946488933},{"date":"2024-08-16","current":-18.655115,"twenty":-18.884076,"median":-10.488762,"eighty":45.307924,"marketCap":6822940561},{"date":"2024-08-23","current":-19.004911,"twenty":-18.92096,"median":-10.554325,"eighty":45.307924,"marketCap":6950875266},{"date":"2024-08-30","current":-19.948361,"twenty":-18.942377,"median":-10.636992,"eighty":45.307924,"marketCap":7295933440},{"date":"2024-09-06","current":-19.248769,"twenty":-18.979477,"median":-10.675476,"eighty":45.307924,"marketCap":7040064031},{"date":"2024-09-13","current":-17.667381,"twenty":-18.992918,"median":-10.762419,"eighty":45.307924,"marketCap":6461685590},{"date":"2024-09-20","current":-18.408188,"twenty":-18.992918,"median":-10.826557,"eighty":45.307924,"marketCap":6732629014},{"date":"2024-09-27","current":-17.701837,"twenty":-18.992918,"median":-11.068858,"eighty":45.307924,"marketCap":6474287610},{"date":"2024-10-04","current":-16.284829,"twenty":-18.992918,"median":-11.242743,"eighty":45.307924,"marketCap":5956029551},{"date":"2024-10-11","current":-16.345127,"twenty":-18.992918,"median":-12.040191,"eighty":45.307924,"marketCap":5978083085},{"date":"2024-10-18","current":-16.577706,"twenty":-18.992918,"median":-13.03948,"eighty":45.307924,"marketCap":6063146718},{"date":"2024-10-25","current":-16.698302,"twenty":-18.992918,"median":-13.446915,"eighty":45.307924,"marketCap":6107253787},{"date":"2024-10-31","current":-16.909346,"twenty":-18.992918,"median":-13.562755,"eighty":45.307924,"marketCap":6184441157},{"date":"2024-11-08","current":-16.902216,"twenty":-18.995317,"median":-13.748329,"eighty":45.31946,"marketCap":6072729658},{"date":"2024-11-15","current":-16.383322,"twenty":-18.995317,"median":-13.840323,"eighty":45.31946,"marketCap":5878515995},{"date":"2024-11-22","current":-14.935534,"twenty":-18.995317,"median":-14.176174,"eighty":45.31946,"marketCap":5359033920},{"date":"2024-11-29","current":-15.723236,"twenty":-18.995317,"median":-14.25989,"eighty":45.31946,"marketCap":5641670064},{"date":"2024-12-06","current":-16.172094,"twenty":-18.995317,"median":-14.506273,"eighty":45.31946,"marketCap":5802725297},{"date":"2024-12-13","current":-16.286509,"twenty":-18.995317,"median":-14.813304,"eighty":45.31946,"marketCap":5843778591},{"date":"2024-12-20","current":-15.661628,"twenty":-18.995317,"median":-14.935534,"eighty":45.31946,"marketCap":5619564444},{"date":"2024-12-27","current":-15.98727,"twenty":-18.995317,"median":-15.08243,"eighty":45.31946,"marketCap":5736408436},{"date":"2025-01-03","current":-15.265577,"twenty":-18.995317,"median":-15.112755,"eighty":45.31946,"marketCap":5477456886},{"date":"2025-01-10","current":-15.005943,"twenty":-18.997715,"median":-15.244128,"eighty":45.330996,"marketCap":5384297486},{"date":"2025-01-17","current":-14.205039,"twenty":-18.997715,"median":-15.281457,"eighty":45.330996,"marketCap":5096924424},{"date":"2025-01-24","current":-15.164364,"twenty":-18.997715,"median":-15.281457,"eighty":45.330996,"marketCap":5441140510},{"date":"2025-01-31","current":-14.662699,"twenty":-18.997715,"median":-15.294658,"eighty":45.330996,"marketCap":5261137602},{"date":"2025-02-07","current":-14.359059,"twenty":-18.997715,"median":-15.294658,"eighty":45.330996,"marketCap":5152188474},{"date":"2025-02-14","current":-13.35573,"twenty":-18.997715,"median":-15.294658,"eighty":45.330996,"marketCap":4792182660},{"date":"2025-02-21","current":-11.446164,"twenty":-18.997715,"median":-15.294658,"eighty":45.330996,"marketCap":5196558396},{"date":"2025-02-28","current":-10.979464,"twenty":-18.997715,"median":-15.294658,"eighty":45.330996,"marketCap":4983545602},{"date":"2025-03-07","current":-12.044139,"twenty":-19.000114,"median":-15.297336,"eighty":45.342533,"marketCap":5466798509},{"date":"2025-03-14","current":-11.522308,"twenty":-19.000114,"median":-15.297336,"eighty":45.342533,"marketCap":5229940998},{"date":"2025-03-21","current":-11.46277,"twenty":-19.000114,"median":-15.297336,"eighty":45.342533,"marketCap":5202916987},{"date":"2025-03-28","current":-11.109046,"twenty":-19.000114,"median":-15.297336,"eighty":45.342533,"marketCap":5042362567},{"date":"2025-04-04","current":-9.988335,"twenty":-19.000114,"median":-15.297336,"eighty":45.342533,"marketCap":4533675297},{"date":"2025-04-11","current":-9.354433,"twenty":-18.997715,"median":-15.294658,"eighty":45.330996,"marketCap":4245949060},{"date":"2025-04-17","current":-9.928797,"twenty":-18.997715,"median":-15.294658,"eighty":45.330996,"marketCap":4506651286},{"date":"2025-04-25","current":-10.356068,"twenty":-19.000114,"median":-15.297336,"eighty":45.342533,"marketCap":4700588308},{"date":"2025-05-02","current":-11.018739,"twenty":-19.000114,"median":-15.297336,"eighty":45.342533,"marketCap":5046935029},{"date":"2025-05-09","current":-11.380123,"twenty":-19.000114,"median":-15.297336,"eighty":45.26178,"marketCap":5212460492},{"date":"2025-05-16","current":-11.463519,"twenty":-19.000114,"median":-15.297336,"eighty":45.175259,"marketCap":5250658676},{"date":"2025-05-23","current":-11.55734,"twenty":-19.000114,"median":-15.297336,"eighty":45.175259,"marketCap":5293631632},{"date":"2025-05-30","current":-11.626837,"twenty":-19.000114,"median":-15.297336,"eighty":45.007986,"marketCap":5325463452},{"date":"2025-06-06","current":-12.24536,"twenty":-19.000114,"median":-15.297336,"eighty":44.117786,"marketCap":5608766648},{"date":"2025-06-13","current":-12.377404,"twenty":-19.000114,"median":-15.297336,"eighty":-6.098308,"marketCap":5669247106},{"date":"2025-06-20","current":-12.860408,"twenty":-19.002512,"median":-15.301886,"eighty":-6.769341,"marketCap":5890478253},{"date":"2025-06-27","current":-13.82294,"twenty":-19.002512,"median":-15.301886,"eighty":-6.989146,"marketCap":6331348958},{"date":"2025-07-03","current":-14.941841,"twenty":-19.002512,"median":-15.301886,"eighty":-7.017492,"marketCap":6843841257},{"date":"2025-07-11","current":-14.7264,"twenty":-19.002512,"median":-15.301886,"eighty":-7.061175,"marketCap":6745162615},{"date":"2025-07-18","current":-14.653429,"twenty":-19.002512,"median":-15.301886,"eighty":-7.105786,"marketCap":6711739204},{"date":"2025-07-25","current":-14.646479,"twenty":-19.002512,"median":-15.301886,"eighty":-7.221033,"marketCap":6708556022},{"date":"2025-08-01","current":-25.541485,"twenty":-19.026904,"median":-15.342587,"eighty":-7.288415,"marketCap":6850635022},{"date":"2025-08-08","current":-24.394555,"twenty":-19.059439,"median":-15.406519,"eighty":-7.31955,"marketCap":6543009950},{"date":"2025-08-15","current":-25.464231,"twenty":-19.208439,"median":-15.476942,"eighty":-7.439444,"marketCap":6829914162},{"date":"2025-08-22","current":-25.693023,"twenty":-19.327123,"median":-15.573133,"eighty":-7.500784,"marketCap":6891279785},{"date":"2025-08-29","current":-25.32755,"twenty":-19.462842,"median":-15.656683,"eighty":-7.572814,"marketCap":6793254179},{"date":"2025-09-05","current":-35.269594,"twenty":-19.610183,"median":-15.723236,"eighty":-7.595584,"marketCap":9459869441},{"date":"2025-09-12","current":-38.056694,"twenty":-19.731561,"median":-15.763036,"eighty":-7.642541,"marketCap":10207414305},{"date":"2025-09-19","current":-36.689886,"twenty":-19.905803,"median":-15.876073,"eighty":-7.741966,"marketCap":9840814478},{"date":"2025-09-26","current":-37.420831,"twenty":-20.021346,"median":-16.03996,"eighty":-7.801291,"marketCap":10036865690},{"date":"2025-10-03","current":-40.647687,"twenty":-20.250766,"median":-16.203648,"eighty":-7.855354,"marketCap":10902360063},{"date":"2025-10-10","current":-41.758962,"twenty":-20.936243,"median":-16.267488,"eighty":-8.057965,"marketCap":11200421661},{"date":"2025-10-17","current":-43.422902,"twenty":-21.44548,"median":-16.302057,"eighty":-8.466659,"marketCap":11646717103},{"date":"2025-10-24","current":-42.489907,"twenty":-21.627284,"median":-16.365719,"eighty":-8.619683,"marketCap":11396472873},{"date":"2025-10-31","current":-46.865674,"twenty":-22.311833,"median":-16.491552,"eighty":-8.824572,"marketCap":12013640728},{"date":"2025-11-07","current":-46.821444,"twenty":-24.565703,"median":-16.551864,"eighty":-9.220997,"marketCap":12002302521},{"date":"2025-11-14","current":-44.129685,"twenty":-25.310911,"median":-16.577552,"eighty":-9.310347,"marketCap":11312291607},{"date":"2025-11-21","current":-46.202213,"twenty":-25.459477,"median":-16.623152,"eighty":-9.406991,"marketCap":11843567616},{"date":"2025-11-28","current":-52.274467,"twenty":-25.606854,"median":-16.659586,"eighty":-9.54788,"marketCap":13400141532},{"date":"2025-12-05","current":-51.693149,"twenty":-25.977676,"median":-16.714478,"eighty":-9.709339,"marketCap":13251125091},{"date":"2025-12-12","current":-50.00606,"twenty":-36.254884,"median":-16.738094,"eighty":-9.817591,"marketCap":12818653462},{"date":"2025-12-19","current":-49.051939,"twenty":-36.458718,"median":-16.773398,"eighty":-9.930898,"marketCap":12574072128},{"date":"2025-12-26","current":-50.960181,"twenty":-37.51116,"median":-16.804783,"eighty":-9.964551,"marketCap":13063234795},{"date":"2026-01-02","current":-49.987104,"twenty":-38.080464,"median":-16.872737,"eighty":-9.994875,"marketCap":12813794230},{"date":"2026-01-09","current":-51.522544,"twenty":-40.33867,"median":-16.913584,"eighty":-10.055281,"marketCap":13207392005},{"date":"2026-01-16","current":-48.786554,"twenty":-41.579494,"median":-16.936559,"eighty":-10.101905,"marketCap":12506042883},{"date":"2026-01-23","current":-51.680511,"twenty":-42.352038,"median":-16.969214,"eighty":-10.147872,"marketCap":13247885603},{"date":"2026-01-30","current":-53.001116,"twenty":-43.304049,"median":-17.016336,"eighty":-10.177655,"marketCap":13586412084},{"date":"2026-02-06","current":-52.748369,"twenty":-43.896106,"median":-17.042828,"eighty":-10.276361,"marketCap":13521622327},{"date":"2026-02-13","current":-51.674193,"twenty":-45.89007,"median":-17.08842,"eighty":-10.365331,"marketCap":13246265859},{"date":"2026-02-20","current":-52.536693,"twenty":-46.437268,"median":-17.113581,"eighty":-10.415699,"marketCap":13467360905},{"date":"2026-02-27","current":-34.265449,"twenty":-46.808807,"median":-17.154283,"eighty":-10.419492,"marketCap":13055136075},{"date":"2026-03-06","current":-32.554417,"twenty":-46.808807,"median":-17.180856,"eighty":-10.419492,"marketCap":12415831546},{"date":"2026-03-13","current":-31.332977,"twenty":-46.808807,"median":-17.209871,"eighty":-10.419492,"marketCap":11949990075},{"date":"2026-03-20","current":-30.891179,"twenty":-46.808807,"median":-17.218631,"eighty":-10.419492,"marketCap":11781494224},{"date":"2026-03-27","current":-32.155933,"twenty":-46.808807,"median":-17.24834,"eighty":-10.419492,"marketCap":12263854896},{"date":"2026-04-02","current":-32.541423,"twenty":-46.808807,"median":-17.287579,"eighty":-10.419492,"marketCap":12410875786},{"date":"2026-04-10","current":-33.104499,"twenty":-46.808807,"median":-17.33251,"eighty":-10.419492,"marketCap":12625625400},{"date":"2026-04-16","current":-33.273421,"twenty":-46.808807,"median":-17.348546,"eighty":-10.419492,"marketCap":12690050285}],"updateTime":1776425873041},"$inf$@#url:\"https://stock-news.skytigris.cn/v3/notice/important/events/list\",params:#symbol:\"IONS\",pageSize:20,pageCount:15,market:\"us\",,,undefined,":[{"items":[{"cdn_pdf":false,"hasAttachments":true,"id":"12691940","market":"us","labels":[],"media":"sec.gov","original_id":"AN87401521000074-IONS","pdf_url":null,"pub_time":1620144000000,"showTitleType":true,"size":0,"source":"sec_us","summary":"10-Q - Quarterly report [Sections 13 or 15(d)]","symbol":"IONS","title":"10-Q - Quarterly report [Sections 13 or 15(d)]","titleType":"季度報告","type":"usFinancials","url":"https://www.sec.gov/Archives/edgar/data/874015/000087401521000074/0000874015-21-000074-index.htm","us_notice_code":"Form 10-Q","us_title_en":"10-Q - Quarterly report [Sections 13 or 15(d)]","is_important":0,"hasEarnInfos":true,"gpt_zh_title":"","gpt_en_title":"","attachments":[{"description":"IONIS PHARMACEUTICALS INC 10-Q 3-31-2021","seq":1,"linkUrl":"https://www.sec.gov/Archives/edgar/data/874015/000087401521000074/form10q.htm","primary":true,"translateUrl":null,"linkName":"form10q.htm","type":"10-Q","id":"NTFILE8fGWR9qJApYjb13w","market":"us","size":1771028},{"description":"EXHIBIT 10.1","seq":2,"linkUrl":"https://www.sec.gov/Archives/edgar/data/874015/000087401521000074/ex10_1.htm","primary":false,"translateUrl":null,"linkName":"ex10_1.htm","type":"EX-10.1","id":"NTFILEE41hGtpBm4Jjtyo5","market":"us","size":14412},{"description":"EXHIBIT 10.2","seq":3,"linkUrl":"https://www.sec.gov/Archives/edgar/data/874015/000087401521000074/ex10_2.htm","primary":false,"translateUrl":null,"linkName":"ex10_2.htm","type":"EX-10.2","id":"NTFILE9ur4JZ7Ugz52Kq1F","market":"us","size":20459},{"description":"EXHIBIT 31.1","seq":4,"linkUrl":"https://www.sec.gov/Archives/edgar/data/874015/000087401521000074/ex31_1.htm","primary":false,"translateUrl":null,"linkName":"ex31_1.htm","type":"EX-31.1","id":"NTFILECK2JMXTcN7UDE7Ct","market":"us","size":13610},{"description":"EXHIBIT 31.2","seq":5,"linkUrl":"https://www.sec.gov/Archives/edgar/data/874015/000087401521000074/ex31_2.htm","primary":false,"translateUrl":null,"linkName":"ex31_2.htm","type":"EX-31.2","id":"NTFILEEbF6h5CoWAwBnkkr","market":"us","size":13459},{"description":"EXHIBIT 32.1","seq":6,"linkUrl":"https://www.sec.gov/Archives/edgar/data/874015/000087401521000074/ex32_1.htm","primary":false,"translateUrl":null,"linkName":"ex32_1.htm","type":"EX-32.1","id":"NTFILE2pw7XCTVFhucsoQo","market":"us","size":7014}],"type_name":"財務報告","type_name_en":"Financial Report","titleTypeEn":"Quarterly Report","us_type":"usFinancials","us_type_zh":"財務報告","earn_infos":[{"id":79293,"name":"CONDENSED CONSOLIDATED BALANCE SHEETS","name_zh":null,"url":"https://www.sec.gov/Archives/edgar/data/874015/000087401521000074/R2.htm","cdn_url":"","translation_url":"","translate_status":0},{"id":79294,"name":"CONDENSED CONSOLIDATED BALANCE SHEETS (Parenthetical)","name_zh":null,"url":"https://www.sec.gov/Archives/edgar/data/874015/000087401521000074/R3.htm","cdn_url":"","translation_url":"","translate_status":0},{"id":79295,"name":"CONDENSED CONSOLIDATED STATEMENTS OF OPERATIONS","name_zh":null,"url":"https://www.sec.gov/Archives/edgar/data/874015/000087401521000074/R4.htm","cdn_url":"","translation_url":"","translate_status":0},{"id":79296,"name":"CONDENSED CONSOLIDATED STATEMENTS OF COMPREHENSIVE LOSS","name_zh":null,"url":"https://www.sec.gov/Archives/edgar/data/874015/000087401521000074/R5.htm","cdn_url":"","translation_url":"","translate_status":0},{"id":79297,"name":"CONDENSED CONSOLIDATED STATEMENTS OF STOCKHOLDERS' EQUITY","name_zh":null,"url":"https://www.sec.gov/Archives/edgar/data/874015/000087401521000074/R6.htm","cdn_url":"","translation_url":"","translate_status":0},{"id":79298,"name":"CONDENSED CONSOLIDATED STATEMENTS OF CASH FLOWS","name_zh":"簡明綜合現金流量表","url":"https://www.sec.gov/Archives/edgar/data/874015/000087401521000074/R7.htm","cdn_url":"https://static.tigerbbs.com/97919d23688489946a9b0f6baefc6441","translation_url":"https://static.tigerbbs.com/f508ba8eb6048712ad95c168a972a29f","translate_status":1}],"event_type":"important_notice","event_name":"季度報告","pubTime":"2021-05-05 00:00","pubTimestamp":1620144000,"title_zh":"10-Q - Quarterly report [Sections 13 or 15(d","summary_en":"","summary_zh":"","notice_type":"","filling_tag":"","gpt_icon":0},{"cdn_pdf":false,"hasAttachments":true,"id":"12691598","market":"us","labels":[],"media":"sec.gov","original_id":"AN114036121015877-IONS","pdf_url":null,"pub_time":1620144000000,"showTitleType":true,"size":0,"source":"sec_us","summary":"8-K - Current report","symbol":"IONS","title":"8-K - Current report","titleType":"重要事件披露","type":"usAnnouncement","url":"https://www.sec.gov/Archives/edgar/data/874015/000114036121015877/0001140361-21-015877-index.htm","us_notice_code":"Form 8-K","us_title_en":"Item 2.02: Results of Operations and Financial Condition;\nItem 9.01: Financial Statements and Exhibits","is_important":0,"hasEarnInfos":false,"gpt_zh_title":"","gpt_en_title":"","attachments":[{"description":"EXHIBIT 99.1","seq":1,"linkUrl":"https://www.sec.gov/Archives/edgar/data/874015/000114036121015877/brhc10024102_ex99-1.htm","primary":true,"translateUrl":null,"linkName":"brhc10024102_ex99-1.htm","type":"EX-99.1","id":"NTFILEFV36cu9eKs2Zo57B","market":"us","size":234626},{"description":"8-K","seq":2,"linkUrl":"https://www.sec.gov/Archives/edgar/data/874015/000114036121015877/brhc10024102_8k.htm","primary":false,"translateUrl":null,"linkName":"brhc10024102_8k.htm","type":"8-K","id":"NTFILEv92rppfq4TGfuiLe","market":"us","size":27237},{"description":"","seq":6,"linkUrl":"https://www.sec.gov/Archives/edgar/data/874015/000114036121015877/image1.jpg","primary":false,"translateUrl":null,"linkName":"image1.jpg","type":"GRAPHIC","id":"NTFILE953c8EoodQopJfUd","market":"us","size":803},{"description":"","seq":7,"linkUrl":"https://www.sec.gov/Archives/edgar/data/874015/000114036121015877/image00002.jpg","primary":false,"translateUrl":null,"linkName":"image00002.jpg","type":"GRAPHIC","id":"NTFILEFLd85Dng7WkxoAab","market":"us","size":4803}],"type_name":"交易披露","type_name_en":"Transaction Related","titleTypeEn":"Major Issues Report","us_type":"usAnnouncement","us_type_zh":"交易披露","earn_infos":[],"event_type":"important_notice","event_name":"重要事件披露","pubTime":"2021-05-05 00:00","pubTimestamp":1620144000,"title_zh":"8-K - Current report","summary_en":"Item 2.02: Results of Operations and Financial Condition;\nItem 9.01: Financial Statements and Exhibits","summary_zh":"項目2.02：經營成果和財務狀況；項目9.01：財務報表和證物","notice_type":"","filling_tag":"","gpt_icon":0},{"cdn_pdf":false,"hasAttachments":true,"id":"12503066","market":"us","labels":[],"media":"sec.gov","original_id":"AN119312521113586-IONS","pdf_url":null,"pub_time":1618243200000,"showTitleType":true,"size":0,"source":"sec_us","summary":"8-K - Current report","symbol":"IONS","title":"8-K - Current report","titleType":"重要事件披露","type":"usAnnouncement","url":"https://www.sec.gov/Archives/edgar/data/874015/000119312521113586/0001193125-21-113586-index.htm","us_notice_code":"Form 8-K","us_title_en":"Item 1.01: Entry into a Material Definitive Agreement;\nItem 2.03: Creation of a Direct Financial Obligation or an Obligation under an Off-Balance Sheet Arrangement of a Registrant;\nItem 3.02: Unregistered Sales of Equity Securities;\nItem 8.01: Other Events;\nItem 9.01: Financial Statements and Exhibits","is_important":0,"hasEarnInfos":false,"gpt_zh_title":"","gpt_en_title":"","attachments":[{"description":"EX-4.1","seq":1,"linkUrl":"https://www.sec.gov/Archives/edgar/data/874015/000119312521113586/d158901dex41.htm","primary":true,"translateUrl":null,"linkName":"d158901dex41.htm","type":"EX-4.1","id":"NTFILECKoN9ogZt6ti1ju6","market":"us","size":625984},{"description":"8-K","seq":2,"linkUrl":"https://www.sec.gov/Archives/edgar/data/874015/000119312521113586/d158901d8k.htm","primary":false,"translateUrl":null,"linkName":"d158901d8k.htm","type":"8-K","id":"NTFILEAGkvYWzDWos28U32","market":"us","size":53197},{"description":"EX-10.1","seq":3,"linkUrl":"https://www.sec.gov/Archives/edgar/data/874015/000119312521113586/d158901dex101.htm","primary":false,"translateUrl":null,"linkName":"d158901dex101.htm","type":"EX-10.1","id":"NTFILEFtVowdZ7q3uVCio7","market":"us","size":237602},{"description":"EX-10.2","seq":4,"linkUrl":"https://www.sec.gov/Archives/edgar/data/874015/000119312521113586/d158901dex102.htm","primary":false,"translateUrl":null,"linkName":"d158901dex102.htm","type":"EX-10.2","id":"NTFILE4MFWumkcK11dPnra","market":"us","size":252517},{"description":"EX-99.1","seq":5,"linkUrl":"https://www.sec.gov/Archives/edgar/data/874015/000119312521113586/d158901dex991.htm","primary":false,"translateUrl":null,"linkName":"d158901dex991.htm","type":"EX-99.1","id":"NTFILEF6WnfX8d84QFYPLQ","market":"us","size":11830},{"description":"EX-99.2","seq":6,"linkUrl":"https://www.sec.gov/Archives/edgar/data/874015/000119312521113586/d158901dex992.htm","primary":false,"translateUrl":null,"linkName":"d158901dex992.htm","type":"EX-99.2","id":"NTFILE4wJrcjgiCEgkSJWU","market":"us","size":14692},{"description":"GRAPHIC","seq":10,"linkUrl":"https://www.sec.gov/Archives/edgar/data/874015/000119312521113586/g158901page71a.jpg","primary":false,"translateUrl":null,"linkName":"g158901page71a.jpg","type":"GRAPHIC","id":"NTFILEE7gbe4dmN72ymo9P","market":"us","size":2359},{"description":"GRAPHIC","seq":11,"linkUrl":"https://www.sec.gov/Archives/edgar/data/874015/000119312521113586/g158901page72a.jpg","primary":false,"translateUrl":null,"linkName":"g158901page72a.jpg","type":"GRAPHIC","id":"NTFILEDVxLtuKNafEfBTFE","market":"us","size":2966},{"description":"GRAPHIC","seq":12,"linkUrl":"https://www.sec.gov/Archives/edgar/data/874015/000119312521113586/g158901page73a.jpg","primary":false,"translateUrl":null,"linkName":"g158901page73a.jpg","type":"GRAPHIC","id":"NTFILECjTMGs44nMq9UnzT","market":"us","size":3000},{"description":"GRAPHIC","seq":13,"linkUrl":"https://www.sec.gov/Archives/edgar/data/874015/000119312521113586/g158901page74a.jpg","primary":false,"translateUrl":null,"linkName":"g158901page74a.jpg","type":"GRAPHIC","id":"NTFILEEu963jzPr7kitbXe","market":"us","size":3169},{"description":"GRAPHIC","seq":14,"linkUrl":"https://www.sec.gov/Archives/edgar/data/874015/000119312521113586/g158901page76a.jpg","primary":false,"translateUrl":null,"linkName":"g158901page76a.jpg","type":"GRAPHIC","id":"NTFILE7u5UcaBfGZ8XRUKx","market":"us","size":2699},{"description":"GRAPHIC","seq":15,"linkUrl":"https://www.sec.gov/Archives/edgar/data/874015/000119312521113586/g158901page77a.jpg","primary":false,"translateUrl":null,"linkName":"g158901page77a.jpg","type":"GRAPHIC","id":"NTFILEFejfzZPpsRBosrF4","market":"us","size":3717}],"type_name":"交易披露","type_name_en":"Transaction Related","titleTypeEn":"Major Issues Report","us_type":"usAnnouncement","us_type_zh":"交易披露","earn_infos":[],"event_type":"important_notice","event_name":"重要事件披露","pubTime":"2021-04-13 00:00","pubTimestamp":1618243200,"title_zh":"8-K - Current report","summary_en":"Item 1.01: Entry into a Material Definitive Agreement;\nItem 2.03: Creation of a Direct Financial Obligation or an Obligation under an Off-Balance Sheet Arrangement of a Registrant;\nItem 3.02: Unregistered Sales of Equity Securities;\nItem 8.01: Other Events;\nItem 9.01: Financial Statements and Exhibits","summary_zh":"第1.01項：訂立重要最終協議；項目2.03：設定登記人的直接財務債務或資產負債表外安排下的債務；第3.02項：未登記出售權益性證券；項目8.01：其他項目；項目9.01：財務報表和證物","notice_type":"","filling_tag":"","gpt_icon":0},{"cdn_pdf":false,"hasAttachments":true,"id":"12468663","market":"us","labels":[],"media":"sec.gov","original_id":"AN114036121011725-IONS","pdf_url":null,"pub_time":1617638400000,"showTitleType":true,"size":0,"source":"sec_us","summary":"8-K - Current report","symbol":"IONS","title":"8-K - Current report","titleType":"重要事件披露","type":"usAnnouncement","url":"https://www.sec.gov/Archives/edgar/data/874015/000114036121011725/0001140361-21-011725-index.htm","us_notice_code":"Form 8-K","us_title_en":"Item 2.05: Cost Associated with Exit or Disposal Activities","is_important":0,"hasEarnInfos":false,"gpt_zh_title":"","gpt_en_title":"","attachments":[{"description":"8-K","seq":1,"linkUrl":"https://www.sec.gov/Archives/edgar/data/874015/000114036121011725/brhc10022825_8k.htm","primary":true,"translateUrl":null,"linkName":"brhc10022825_8k.htm","type":"8-K","id":"NTFILE8zj1vRm7aLrafaaH","market":"us","size":26108}],"type_name":"交易披露","type_name_en":"Transaction Related","titleTypeEn":"Major Issues Report","us_type":"usAnnouncement","us_type_zh":"交易披露","earn_infos":[],"event_type":"important_notice","event_name":"重要事件披露","pubTime":"2021-04-06 00:00","pubTimestamp":1617638400,"title_zh":"8-K - Current report","summary_en":"Item 2.05: Cost Associated with Exit or Disposal Activities","summary_zh":"項目2.05：與退出或處置活動有關的費用","notice_type":"","filling_tag":"","gpt_icon":0},{"cdn_pdf":false,"hasAttachments":true,"id":"12394137","market":"us","labels":[],"media":"sec.gov","original_id":"AN114036121010402-IONS","pdf_url":null,"pub_time":1616947200000,"showTitleType":true,"size":0,"source":"sec_us","summary":"8-K - Current report","symbol":"IONS","title":"8-K - Current report","titleType":"重要事件披露","type":"usAnnouncement","url":"https://www.sec.gov/Archives/edgar/data/874015/000114036121010402/0001140361-21-010402-index.htm","us_notice_code":"Form 8-K","us_title_en":"Item 5.03: Amendments to Articles of Incorporation or Bylaws; Change in Fiscal Year;\nItem 5.05: Amendments to the Registrant's Code of Ethics, or Waiver of a Provision of the Code of Ethics;\nItem 9.01: Financial Statements and Exhibits","is_important":0,"hasEarnInfos":false,"gpt_zh_title":"","gpt_en_title":"","attachments":[{"description":"EXHIBIT 3.1","seq":1,"linkUrl":"https://www.sec.gov/Archives/edgar/data/874015/000114036121010402/brhc10022399_ex3-1.htm","primary":true,"translateUrl":null,"linkName":"brhc10022399_ex3-1.htm","type":"EX-3.1","id":"NTFILEp5azvXtcM74aJJ1Z","market":"us","size":221938},{"description":"8-K","seq":2,"linkUrl":"https://www.sec.gov/Archives/edgar/data/874015/000114036121010402/brhc10022399_8k.htm","primary":false,"translateUrl":null,"linkName":"brhc10022399_8k.htm","type":"8-K","id":"NTFILEDkP8ATSNJVM3VN9o","market":"us","size":28310},{"description":"EXHIBIT 14.1","seq":3,"linkUrl":"https://www.sec.gov/Archives/edgar/data/874015/000114036121010402/brhc10022399_ex14-1.htm","primary":false,"translateUrl":null,"linkName":"brhc10022399_ex14-1.htm","type":"EX-14.1","id":"NTFILE5N5TJNvpcHThaHeX","market":"us","size":102773}],"type_name":"交易披露","type_name_en":"Transaction Related","titleTypeEn":"Major Issues Report","us_type":"usAnnouncement","us_type_zh":"交易披露","earn_infos":[],"event_type":"important_notice","event_name":"重要事件披露","pubTime":"2021-03-29 00:00","pubTimestamp":1616947200,"title_zh":"8-K - Current report","summary_en":"Item 5.03: Amendments to Articles of Incorporation or Bylaws; Change in Fiscal Year;\nItem 5.05: Amendments to the Registrant's Code of Ethics, or Waiver of a Provision of the Code of Ethics;\nItem 9.01: Financial Statements and Exhibits","summary_zh":"第5.03項：修改公司章程或章程細則；會計年度的變化；項目5.05：修改註冊人的道德守則，或放棄道德守則的一項規定；項目9.01：財務報表和證物","notice_type":"","filling_tag":"","gpt_icon":0},{"cdn_pdf":false,"hasAttachments":true,"id":"12394140","market":"us","labels":[],"media":"sec.gov","original_id":"AN114036121009508-IONS","pdf_url":null,"pub_time":1616428800000,"showTitleType":true,"size":0,"source":"sec_us","summary":"8-K - Current report","symbol":"IONS","title":"8-K - Current report","titleType":"重要事件披露","type":"usAnnouncement","url":"https://www.sec.gov/Archives/edgar/data/874015/000114036121009508/0001140361-21-009508-index.htm","us_notice_code":"Form 8-K","us_title_en":"Item 8.01: Other Events;\nItem 9.01: Financial Statements and Exhibits","is_important":0,"hasEarnInfos":false,"gpt_zh_title":"","gpt_en_title":"","attachments":[{"description":"EXHIBIT 99.1","seq":1,"linkUrl":"https://www.sec.gov/Archives/edgar/data/874015/000114036121009508/brhc10022120_ex99-1.htm","primary":true,"translateUrl":null,"linkName":"brhc10022120_ex99-1.htm","type":"EX-99.1","id":"NTFILE8U27iFPDT46Ary1v","market":"us","size":18961},{"description":"8-K","seq":2,"linkUrl":"https://www.sec.gov/Archives/edgar/data/874015/000114036121009508/brhc10022120_8k.htm","primary":false,"translateUrl":null,"linkName":"brhc10022120_8k.htm","type":"8-K","id":"NTFILE48BQfCLd5XGKyJqd","market":"us","size":25265},{"description":"","seq":6,"linkUrl":"https://www.sec.gov/Archives/edgar/data/874015/000114036121009508/image0.jpg","primary":false,"translateUrl":null,"linkName":"image0.jpg","type":"GRAPHIC","id":"NTFILEEemPvJzkZmwaEoGP","market":"us","size":11357}],"type_name":"交易披露","type_name_en":"Transaction Related","titleTypeEn":"Major Issues Report","us_type":"usAnnouncement","us_type_zh":"交易披露","earn_infos":[],"event_type":"important_notice","event_name":"重要事件披露","pubTime":"2021-03-23 00:00","pubTimestamp":1616428800,"title_zh":"8-K - Current report","summary_en":"Item 8.01: Other Events;\nItem 9.01: Financial Statements and Exhibits","summary_zh":"項目8.01：其他項目；項目9.01：財務報表和證物","notice_type":"","filling_tag":"","gpt_icon":0},{"cdn_pdf":false,"hasAttachments":true,"id":"11959054","market":"us","labels":[],"media":"sec.gov","original_id":"AN87401521000056-IONS","pdf_url":null,"pub_time":1614096000000,"showTitleType":true,"size":0,"source":"sec_us","summary":"10-K - Annual report [Section 13 and 15(d), not S-K Item 405]","symbol":"IONS","title":"10-K - Annual report [Section 13 and 15(d), not S-K Item 405]","titleType":"年度報告","type":"usFinancials","url":"https://www.sec.gov/Archives/edgar/data/874015/000087401521000056/0000874015-21-000056-index.htm","us_notice_code":"Form 10-K","us_title_en":"10-K - Annual report [Section 13 and 15(d), not S-K Item 405]","is_important":0,"hasEarnInfos":false,"gpt_zh_title":"","gpt_en_title":"","attachments":[{"description":"IONIS PHARMACEUTICALS, INC. 10-K 12-31-2020","seq":1,"linkUrl":"https://www.sec.gov/Archives/edgar/data/874015/000087401521000056/form10k.htm","primary":true,"translateUrl":null,"linkName":"form10k.htm","type":"10-K","id":"NTFILEGYmUfE6UxJUkH3Li","market":"us","size":4240904},{"description":"EXHIBIT 10.18","seq":2,"linkUrl":"https://www.sec.gov/Archives/edgar/data/874015/000087401521000056/exhibit10_18.htm","primary":false,"translateUrl":null,"linkName":"exhibit10_18.htm","type":"EX-10.18","id":"NTFILEP23t71JwPAkvgjmT","market":"us","size":82833},{"description":"EXHIBIT 10.46","seq":3,"linkUrl":"https://www.sec.gov/Archives/edgar/data/874015/000087401521000056/exhibit10_46.htm","primary":false,"translateUrl":null,"linkName":"exhibit10_46.htm","type":"EX-10.46","id":"NTFILE2Mzd2tkFGwqx3gwj","market":"us","size":592701},{"description":"EXHIBIT 56","seq":4,"linkUrl":"https://www.sec.gov/Archives/edgar/data/874015/000087401521000056/exhibit10_56.htm","primary":false,"translateUrl":null,"linkName":"exhibit10_56.htm","type":"EX-10.56","id":"NTFILEARdH8Z1YQnVjFu7q","market":"us","size":37595},{"description":"EXHIBIT 61","seq":5,"linkUrl":"https://www.sec.gov/Archives/edgar/data/874015/000087401521000056/exhibit10_61.htm","primary":false,"translateUrl":null,"linkName":"exhibit10_61.htm","type":"EX-10.61","id":"NTFILE7oWNEtSvWk5ExaH3","market":"us","size":46168},{"description":"EXHIBIT 79","seq":6,"linkUrl":"https://www.sec.gov/Archives/edgar/data/874015/000087401521000056/exhibit10_79.htm","primary":false,"translateUrl":null,"linkName":"exhibit10_79.htm","type":"EX-10.79","id":"NTFILEHS4Q48rCGTt6mvZ1","market":"us","size":13850},{"description":"EXHIBIT 80","seq":7,"linkUrl":"https://www.sec.gov/Archives/edgar/data/874015/000087401521000056/exhibit10_80.htm","primary":false,"translateUrl":null,"linkName":"exhibit10_80.htm","type":"EX-10.80","id":"NTFILE9Cyfo7HDAvivmfjx","market":"us","size":68105},{"description":"EXHIBIT 81","seq":8,"linkUrl":"https://www.sec.gov/Archives/edgar/data/874015/000087401521000056/exhibit10_81.htm","primary":false,"translateUrl":null,"linkName":"exhibit10_81.htm","type":"EX-10.81","id":"NTFILE2kUmmAb8ME82e64t","market":"us","size":72885},{"description":"EXHIBIT 21.1","seq":9,"linkUrl":"https://www.sec.gov/Archives/edgar/data/874015/000087401521000056/exhibit21_1.htm","primary":false,"translateUrl":null,"linkName":"exhibit21_1.htm","type":"EX-21.1","id":"NTFILEGi499jdhHutWqXfd","market":"us","size":3062},{"description":"EXHIBIT 23.1","seq":10,"linkUrl":"https://www.sec.gov/Archives/edgar/data/874015/000087401521000056/exhibit23_1.htm","primary":false,"translateUrl":null,"linkName":"exhibit23_1.htm","type":"EX-23.1","id":"NTFILE9GdeipWQGmLnV1av","market":"us","size":4117},{"description":"EXHIBIT 31.1","seq":11,"linkUrl":"https://www.sec.gov/Archives/edgar/data/874015/000087401521000056/exhibit31_1.htm","primary":false,"translateUrl":null,"linkName":"exhibit31_1.htm","type":"EX-31.1","id":"NTFILEAy2B6wZ5uPDepBc6","market":"us","size":13248},{"description":"EXHIBIT 31.2","seq":12,"linkUrl":"https://www.sec.gov/Archives/edgar/data/874015/000087401521000056/exhibit31_2.htm","primary":false,"translateUrl":null,"linkName":"exhibit31_2.htm","type":"EX-31.2","id":"NTFILEHFZcuvGijAm51NtP","market":"us","size":13256},{"description":"EXHIBIT 32.1","seq":13,"linkUrl":"https://www.sec.gov/Archives/edgar/data/874015/000087401521000056/exhibit32_1.htm","primary":false,"translateUrl":null,"linkName":"exhibit32_1.htm","type":"EX-32","id":"NTFILE9dZ1KzAHGTQj5CYF","market":"us","size":7693},{"description":"","seq":19,"linkUrl":"https://www.sec.gov/Archives/edgar/data/874015/000087401521000056/image01.jpg","primary":false,"translateUrl":null,"linkName":"image01.jpg","type":"GRAPHIC","id":"NTFILEFSe6DbdYZSGierca","market":"us","size":367995},{"description":"","seq":20,"linkUrl":"https://www.sec.gov/Archives/edgar/data/874015/000087401521000056/image02.jpg","primary":false,"translateUrl":null,"linkName":"image02.jpg","type":"GRAPHIC","id":"NTFILEBQ974Ps3ZdBoRhu2","market":"us","size":46106},{"description":"","seq":21,"linkUrl":"https://www.sec.gov/Archives/edgar/data/874015/000087401521000056/image04.jpg","primary":false,"translateUrl":null,"linkName":"image04.jpg","type":"GRAPHIC","id":"NTFILE7jHtxLBFqLqzDCaX","market":"us","size":31669},{"description":"","seq":22,"linkUrl":"https://www.sec.gov/Archives/edgar/data/874015/000087401521000056/image4.jpg","primary":false,"translateUrl":null,"linkName":"image4.jpg","type":"GRAPHIC","id":"NTFILE97RKSdZYCyvfdhJf","market":"us","size":64758},{"description":"","seq":23,"linkUrl":"https://www.sec.gov/Archives/edgar/data/874015/000087401521000056/image05.jpg","primary":false,"translateUrl":null,"linkName":"image05.jpg","type":"GRAPHIC","id":"NTFILE2EFHhfS3XECaZkK2","market":"us","size":25608},{"description":"","seq":24,"linkUrl":"https://www.sec.gov/Archives/edgar/data/874015/000087401521000056/image5.jpg","primary":false,"translateUrl":null,"linkName":"image5.jpg","type":"GRAPHIC","id":"NTFILE97QXgwpx9ft3biuh","market":"us","size":87380},{"description":"","seq":25,"linkUrl":"https://www.sec.gov/Archives/edgar/data/874015/000087401521000056/image06.jpg","primary":false,"translateUrl":null,"linkName":"image06.jpg","type":"GRAPHIC","id":"NTFILE14jiNUTf9NE6Cdw7","market":"us","size":24762},{"description":"","seq":26,"linkUrl":"https://www.sec.gov/Archives/edgar/data/874015/000087401521000056/image7.jpg","primary":false,"translateUrl":null,"linkName":"image7.jpg","type":"GRAPHIC","id":"NTFILEATvawokUQypfqjPW","market":"us","size":105188},{"description":"","seq":27,"linkUrl":"https://www.sec.gov/Archives/edgar/data/874015/000087401521000056/image08.jpg","primary":false,"translateUrl":null,"linkName":"image08.jpg","type":"GRAPHIC","id":"NTFILEeajNEmUPQ93mk6j1","market":"us","size":110291},{"description":"","seq":28,"linkUrl":"https://www.sec.gov/Archives/edgar/data/874015/000087401521000056/image09.jpg","primary":false,"translateUrl":null,"linkName":"image09.jpg","type":"GRAPHIC","id":"NTFILE8Y5qQJ3xbaNjv1Re","market":"us","size":31066},{"description":"","seq":29,"linkUrl":"https://www.sec.gov/Archives/edgar/data/874015/000087401521000056/image10.jpg","primary":false,"translateUrl":null,"linkName":"image10.jpg","type":"GRAPHIC","id":"NTFILE5nSpQ9U3Ncoc9aDZ","market":"us","size":112405},{"description":"","seq":30,"linkUrl":"https://www.sec.gov/Archives/edgar/data/874015/000087401521000056/image11.jpg","primary":false,"translateUrl":null,"linkName":"image11.jpg","type":"GRAPHIC","id":"NTFILE9fB7RJXwjrNVNr96","market":"us","size":936705},{"description":"","seq":31,"linkUrl":"https://www.sec.gov/Archives/edgar/data/874015/000087401521000056/image12.jpg","primary":false,"translateUrl":null,"linkName":"image12.jpg","type":"GRAPHIC","id":"NTFILEHRkCFaki5bwj4783","market":"us","size":129410},{"description":"","seq":32,"linkUrl":"https://www.sec.gov/Archives/edgar/data/874015/000087401521000056/image13.jpg","primary":false,"translateUrl":null,"linkName":"image13.jpg","type":"GRAPHIC","id":"NTFILEHX7uma5mjnEisWh3","market":"us","size":41580},{"description":"","seq":33,"linkUrl":"https://www.sec.gov/Archives/edgar/data/874015/000087401521000056/image15.jpg","primary":false,"translateUrl":null,"linkName":"image15.jpg","type":"GRAPHIC","id":"NTFILE4nrG242GmRcaC6Bx","market":"us","size":9650},{"description":"","seq":34,"linkUrl":"https://www.sec.gov/Archives/edgar/data/874015/000087401521000056/image17.jpg","primary":false,"translateUrl":null,"linkName":"image17.jpg","type":"GRAPHIC","id":"NTFILEJC12s5fyhJJMaA71","market":"us","size":3544},{"description":"","seq":35,"linkUrl":"https://www.sec.gov/Archives/edgar/data/874015/000087401521000056/image00018.jpg","primary":false,"translateUrl":null,"linkName":"image00018.jpg","type":"GRAPHIC","id":"NTFILE8B8P8euWrJHH7fKc","market":"us","size":112488}],"type_name":"財務報告","type_name_en":"Financial Report","titleTypeEn":"Annual Report","us_type":"usFinancials","us_type_zh":"財務報告","earn_infos":[],"event_type":"important_notice","event_name":"年度報告","pubTime":"2021-02-24 00:00","pubTimestamp":1614096000,"title_zh":"10-K - Annual report [Section 13 and 15(d), not S-K Item 405","summary_en":"","summary_zh":"","notice_type":"","filling_tag":"","gpt_icon":0},{"cdn_pdf":false,"hasAttachments":true,"id":"11957840","market":"us","labels":[],"media":"sec.gov","original_id":"AN114036121005959-IONS","pdf_url":null,"pub_time":1614096000000,"showTitleType":true,"size":0,"source":"sec_us","summary":"8-K - Current report","symbol":"IONS","title":"8-K - Current report","titleType":"重要事件披露","type":"usAnnouncement","url":"https://www.sec.gov/Archives/edgar/data/874015/000114036121005959/0001140361-21-005959-index.htm","us_notice_code":"Form 8-K","us_title_en":"Item 2.02: Results of Operations and Financial Condition;\nItem 9.01: Financial Statements and Exhibits","is_important":0,"hasEarnInfos":false,"gpt_zh_title":"","gpt_en_title":"","attachments":[{"description":"EXHIBIT 99.1","seq":1,"linkUrl":"https://www.sec.gov/Archives/edgar/data/874015/000114036121005959/brhc10020770_ex99-1.htm","primary":true,"translateUrl":null,"linkName":"brhc10020770_ex99-1.htm","type":"EX-99.1","id":"NTFILE9BJKL2SgQWvnxaYj","market":"us","size":329958},{"description":"8-K","seq":2,"linkUrl":"https://www.sec.gov/Archives/edgar/data/874015/000114036121005959/brhc10020770_8k.htm","primary":false,"translateUrl":null,"linkName":"brhc10020770_8k.htm","type":"8-K","id":"NTFILE5gv91ZXBYW1edydV","market":"us","size":25918},{"description":"","seq":6,"linkUrl":"https://www.sec.gov/Archives/edgar/data/874015/000114036121005959/image0.jpg","primary":false,"translateUrl":null,"linkName":"image0.jpg","type":"GRAPHIC","id":"NTFILEH5RxS1ew14Xa7Ho7","market":"us","size":11774}],"type_name":"交易披露","type_name_en":"Transaction Related","titleTypeEn":"Major Issues Report","us_type":"usAnnouncement","us_type_zh":"交易披露","earn_infos":[],"event_type":"important_notice","event_name":"重要事件披露","pubTime":"2021-02-24 00:00","pubTimestamp":1614096000,"title_zh":"8-K - Current report","summary_en":"Item 2.02: Results of Operations and Financial Condition;\nItem 9.01: Financial Statements and Exhibits","summary_zh":"項目2.02：經營成果和財務狀況；項目9.01：財務報表和證物","notice_type":"","filling_tag":"","gpt_icon":0},{"cdn_pdf":false,"hasAttachments":false,"id":"11957839","market":"us","labels":[],"media":"sec.gov","original_id":"AN8025521000965-IONS","pdf_url":null,"pub_time":1613404800000,"showTitleType":true,"size":0,"source":"sec_us","summary":"SC 13G - Statement of acquisition of beneficial ownership by individuals","symbol":"IONS","title":"SC 13G - Statement of acquisition of beneficial ownership by individuals","titleType":"超過5%披露","type":"usAnnouncement","url":"https://www.sec.gov/Archives/edgar/data/874015/000008025521000965/0000080255-21-000965-index.htm","us_notice_code":"Form SC 13G","us_title_en":"SC 13G - Statement of acquisition of beneficial ownership by individuals","is_important":0,"hasEarnInfos":false,"gpt_zh_title":"","gpt_en_title":"","attachments":[],"type_name":"交易披露","type_name_en":"Transaction Related","titleTypeEn":"Beneficial Ownership Change","us_type":"usAnnouncement","us_type_zh":"交易披露","earn_infos":[],"event_type":"important_notice","event_name":"超過5%披露","pubTime":"2021-02-16 00:00","pubTimestamp":1613404800,"title_zh":"SC 13G - Statement of acquisition of beneficial ownership by individuals","summary_en":"","summary_zh":"","notice_type":"","filling_tag":"","gpt_icon":0},{"cdn_pdf":false,"hasAttachments":true,"id":"11957842","market":"us","labels":[],"media":"sec.gov","original_id":"AN119312521041468-IONS","pdf_url":null,"pub_time":1613059200000,"showTitleType":true,"size":0,"source":"sec_us","summary":"SC 13G/A [Amend] - Statement of acquisition of beneficial ownership by individuals","symbol":"IONS","title":"SC 13G/A [Amend] - Statement of acquisition of beneficial ownership by individuals","titleType":"超過5%披露","type":"usAnnouncement","url":"https://www.sec.gov/Archives/edgar/data/874015/000119312521041468/0001193125-21-041468-index.htm","us_notice_code":"Form SC 13G/A","us_title_en":"SC 13G/A [Amend] - Statement of acquisition of beneficial ownership by individuals","is_important":0,"hasEarnInfos":false,"gpt_zh_title":"","gpt_en_title":"","attachments":[{"description":"SC 13G/A","seq":1,"linkUrl":"https://www.sec.gov/Archives/edgar/data/874015/000119312521041468/d129891dsc13ga.htm","primary":true,"translateUrl":null,"linkName":"d129891dsc13ga.htm","type":"SC 13G/A","id":"NTFILECupHTwR5gTVhUVAk","market":"us","size":51742}],"type_name":"交易披露","type_name_en":"Transaction Related","titleTypeEn":"Beneficial Ownership Change","us_type":"usAnnouncement","us_type_zh":"交易披露","earn_infos":[],"event_type":"important_notice","event_name":"超過5%披露","pubTime":"2021-02-12 00:00","pubTimestamp":1613059200,"title_zh":"SC 13G/A [Amend] - Statement of acquisition of beneficial ownership by individuals","summary_en":"","summary_zh":"","notice_type":"","filling_tag":"","gpt_icon":0},{"cdn_pdf":false,"hasAttachments":true,"id":"11957844","market":"us","labels":[],"media":"sec.gov","original_id":"AN110465921018387-IONS","pdf_url":null,"pub_time":1612886400000,"showTitleType":true,"size":0,"source":"sec_us","summary":"SC 13G/A [Amend] - Statement of acquisition of beneficial ownership by individuals","symbol":"IONS","title":"SC 13G/A [Amend] - Statement of acquisition of beneficial ownership by individuals","titleType":"超過5%披露","type":"usAnnouncement","url":"https://www.sec.gov/Archives/edgar/data/874015/000110465921018387/0001104659-21-018387-index.htm","us_notice_code":"Form SC 13G/A","us_title_en":"SC 13G/A [Amend] - Statement of acquisition of beneficial ownership by individuals","is_important":0,"hasEarnInfos":false,"gpt_zh_title":"","gpt_en_title":"","attachments":[{"description":"SCHEDULE 13G/A","seq":1,"linkUrl":"https://www.sec.gov/Archives/edgar/data/102909/000110465921018387/tv01163-ionispharmaceuticals.htm","primary":true,"translateUrl":null,"linkName":"tv01163-ionispharmaceuticals.htm","type":"SC 13G/A","id":"NTFILEHyeL6HzMpJpYa7Xb","market":"us","size":12339}],"type_name":"交易披露","type_name_en":"Transaction Related","titleTypeEn":"Beneficial Ownership Change","us_type":"usAnnouncement","us_type_zh":"交易披露","earn_infos":[],"event_type":"important_notice","event_name":"超過5%披露","pubTime":"2021-02-10 00:00","pubTimestamp":1612886400,"title_zh":"SC 13G/A [Amend] - Statement of acquisition of beneficial ownership by individuals","summary_en":"","summary_zh":"","notice_type":"","filling_tag":"","gpt_icon":0},{"cdn_pdf":false,"hasAttachments":true,"id":"11780572","market":"us","labels":[],"media":"sec.gov","original_id":"AN134888321000018-IONS","pdf_url":null,"pub_time":1612800000000,"showTitleType":true,"size":0,"source":"sec_us","summary":"SC 13G/A [Amend] - Statement of acquisition of beneficial ownership by individuals","symbol":"IONS","title":"SC 13G/A [Amend] - Statement of acquisition of beneficial ownership by individuals","titleType":"超過5%披露","type":"usAnnouncement","url":"https://www.sec.gov/Archives/edgar/data/874015/000134888321000018/0001348883-21-000018-index.htm","us_notice_code":"Form SC 13G/A","us_title_en":"SC 13G/A [Amend] - Statement of acquisition of beneficial ownership by individuals","is_important":0,"hasEarnInfos":false,"gpt_zh_title":"","gpt_en_title":"","attachments":[{"description":"","seq":1,"linkUrl":"https://www.sec.gov/Archives/edgar/data/874015/000134888321000018/ioni20a10.htm","primary":true,"translateUrl":null,"linkName":"ioni20a10.htm","type":"SC 13G/A","id":"NTFILEEye88yVsKG6qdy8g","market":"us","size":81767}],"type_name":"交易披露","type_name_en":"Transaction Related","titleTypeEn":"Beneficial Ownership Change","us_type":"usAnnouncement","us_type_zh":"交易披露","earn_infos":[],"event_type":"important_notice","event_name":"超過5%披露","pubTime":"2021-02-09 00:00","pubTimestamp":1612800000,"title_zh":"SC 13G/A [Amend] - Statement of acquisition of beneficial ownership by individuals","summary_en":"","summary_zh":"","notice_type":"","filling_tag":"","gpt_icon":0},{"cdn_pdf":false,"hasAttachments":false,"id":"11780567","market":"us","labels":[],"media":"sec.gov","original_id":"AN31506621001069-IONS","pdf_url":null,"pub_time":1612713600000,"showTitleType":true,"size":0,"source":"sec_us","summary":"SC 13G/A [Amend] - Statement of acquisition of beneficial ownership by individuals","symbol":"IONS","title":"SC 13G/A [Amend] - Statement of acquisition of beneficial ownership by individuals","titleType":"超過5%披露","type":"usAnnouncement","url":"https://www.sec.gov/Archives/edgar/data/874015/000031506621001069/0000315066-21-001069-index.htm","us_notice_code":"Form SC 13G/A","us_title_en":"SC 13G/A [Amend] - Statement of acquisition of beneficial ownership by individuals","is_important":0,"hasEarnInfos":false,"gpt_zh_title":"","gpt_en_title":"","attachments":[],"type_name":"交易披露","type_name_en":"Transaction Related","titleTypeEn":"Beneficial Ownership Change","us_type":"usAnnouncement","us_type_zh":"交易披露","earn_infos":[],"event_type":"important_notice","event_name":"超過5%披露","pubTime":"2021-02-08 00:00","pubTimestamp":1612713600,"title_zh":"SC 13G/A [Amend] - Statement of acquisition of beneficial ownership by individuals","summary_en":"","summary_zh":"","notice_type":"","filling_tag":"","gpt_icon":0},{"cdn_pdf":false,"hasAttachments":false,"id":"11780579","market":"us","labels":[],"media":"sec.gov","original_id":"AN83423721007434-IONS","pdf_url":null,"pub_time":1612454400000,"showTitleType":true,"size":0,"source":"sec_us","summary":"SC 13G/A [Amend] - Statement of acquisition of beneficial ownership by individuals","symbol":"IONS","title":"SC 13G/A [Amend] - Statement of acquisition of beneficial ownership by individuals","titleType":"超過5%披露","type":"usAnnouncement","url":"https://www.sec.gov/Archives/edgar/data/874015/000083423721007434/0000834237-21-007434-index.htm","us_notice_code":"Form SC 13G/A","us_title_en":"SC 13G/A [Amend] - Statement of acquisition of beneficial ownership by individuals","is_important":0,"hasEarnInfos":false,"gpt_zh_title":"","gpt_en_title":"","attachments":[],"type_name":"交易披露","type_name_en":"Transaction Related","titleTypeEn":"Beneficial Ownership Change","us_type":"usAnnouncement","us_type_zh":"交易披露","earn_infos":[],"event_type":"important_notice","event_name":"超過5%披露","pubTime":"2021-02-05 00:00","pubTimestamp":1612454400,"title_zh":"SC 13G/A [Amend] - Statement of acquisition of beneficial ownership by individuals","summary_en":"","summary_zh":"","notice_type":"","filling_tag":"","gpt_icon":0},{"cdn_pdf":false,"hasAttachments":true,"id":"11957845","market":"us","labels":[],"media":"sec.gov","original_id":"AN114036121001189-IONS","pdf_url":null,"pub_time":1610553600000,"showTitleType":true,"size":0,"source":"sec_us","summary":"CORRESP [Cover] - Correspondence","symbol":"IONS","title":"CORRESP [Cover] - Correspondence","titleType":"SEC問詢函","type":"usAnnouncement","url":"https://www.sec.gov/Archives/edgar/data/874015/000114036121001189/0001140361-21-001189-index.htm","us_notice_code":"Form CORRESP","us_title_en":"CORRESP [Cover] - Correspondence","is_important":0,"hasEarnInfos":false,"gpt_zh_title":"","gpt_en_title":"","attachments":[{"description":"","seq":1,"linkUrl":"https://www.sec.gov/Archives/edgar/data/874015/000114036121001189/filename1.htm","primary":true,"translateUrl":null,"linkName":"filename1.htm","type":"CORRESP","id":"NTFILEFHvnykiqEkTFcQrH","market":"us","size":128161}],"type_name":"交易披露","type_name_en":"Transaction Related","titleTypeEn":"Correspondence","us_type":"usAnnouncement","us_type_zh":"交易披露","earn_infos":[],"event_type":"important_notice","event_name":"SEC問詢函","pubTime":"2021-01-14 00:00","pubTimestamp":1610553600,"title_zh":"CORRESP [Cover] - Correspondence","summary_en":"","summary_zh":"","notice_type":"","filling_tag":"","gpt_icon":0},{"cdn_pdf":false,"hasAttachments":true,"id":"11328157","market":"us","labels":[],"media":"sec.gov","original_id":"AN114036120030055-IONS","pdf_url":null,"pub_time":1609344000000,"showTitleType":true,"size":0,"source":"sec_us","summary":"S-8 - Securities to be offered to employees in employee benefit plans","symbol":"IONS","title":"S-8 - Securities to be offered to employees in employee benefit plans","titleType":"員工持股計劃","type":"usAnnouncement","url":"https://www.sec.gov/Archives/edgar/data/874015/000114036120030055/0001140361-20-030055-index.htm","us_notice_code":"Form S-8","us_title_en":"S-8 - Securities to be offered to employees in employee benefit plans","is_important":0,"hasEarnInfos":false,"gpt_zh_title":"","gpt_en_title":"","attachments":[{"description":"S-8","seq":1,"linkUrl":"https://www.sec.gov/Archives/edgar/data/874015/000114036120030055/brhc10018560_s8.htm","primary":true,"translateUrl":null,"linkName":"brhc10018560_s8.htm","type":"S-8","id":"NTFILE1kqo3aWZaeS49R7d","market":"us","size":67602},{"description":"EXHIBIT 5.1","seq":2,"linkUrl":"https://www.sec.gov/Archives/edgar/data/874015/000114036120030055/brhc10018560_ex5-1.htm","primary":false,"translateUrl":null,"linkName":"brhc10018560_ex5-1.htm","type":"EX-5.1","id":"NTFILEGwcqRLip3BPwHQGv","market":"us","size":5059},{"description":"EXHIBIT 23.1","seq":3,"linkUrl":"https://www.sec.gov/Archives/edgar/data/874015/000114036120030055/brhc10018560_ex23-1.htm","primary":false,"translateUrl":null,"linkName":"brhc10018560_ex23-1.htm","type":"EX-23.1","id":"NTFILE6SG1ndqy2KiZ5UDA","market":"us","size":2902},{"description":"EXHIBIT 99.1","seq":4,"linkUrl":"https://www.sec.gov/Archives/edgar/data/874015/000114036120030055/brhc10018560_ex99-1.htm","primary":false,"translateUrl":null,"linkName":"brhc10018560_ex99-1.htm","type":"EX-99.1","id":"NTFILECshz23CYn9Fa1Xjb","market":"us","size":118987},{"description":"EXHIBIT 99.2","seq":5,"linkUrl":"https://www.sec.gov/Archives/edgar/data/874015/000114036120030055/brhc10018560_ex99-2.htm","primary":false,"translateUrl":null,"linkName":"brhc10018560_ex99-2.htm","type":"EX-99.2","id":"NTFILE8FU5kcoJT4Hev11M","market":"us","size":84160},{"description":"EXHIBIT 99.3","seq":6,"linkUrl":"https://www.sec.gov/Archives/edgar/data/874015/000114036120030055/brhc10018560_ex99-3.htm","primary":false,"translateUrl":null,"linkName":"brhc10018560_ex99-3.htm","type":"EX-99.3","id":"NTFILE3ZQeAgiZ9SVdN11a","market":"us","size":92971},{"description":"EXHIBIT 99.4","seq":7,"linkUrl":"https://www.sec.gov/Archives/edgar/data/874015/000114036120030055/brhc10018560_ex99-4.htm","primary":false,"translateUrl":null,"linkName":"brhc10018560_ex99-4.htm","type":"EX-99.4","id":"NTFILE4y8zaCa3GTVFdL8D","market":"us","size":35017}],"type_name":"交易披露","type_name_en":"Transaction Related","titleTypeEn":"Employee Stock Ownership","us_type":"usAnnouncement","us_type_zh":"交易披露","earn_infos":[],"event_type":"important_notice","event_name":"員工持股計劃","pubTime":"2020-12-31 00:00","pubTimestamp":1609344000,"title_zh":"S-8 - Securities to be offered to employees in employee benefit plans","summary_en":"","summary_zh":"","notice_type":"","filling_tag":"","gpt_icon":0},{"cdn_pdf":false,"hasAttachments":true,"id":"11328153","market":"us","labels":[],"media":"sec.gov","original_id":"AN114036120028770-IONS","pdf_url":null,"pub_time":1608220800000,"showTitleType":true,"size":0,"source":"sec_us","summary":"8-K - Current report","symbol":"IONS","title":"8-K - Current report","titleType":"重要事件披露","type":"usAnnouncement","url":"https://www.sec.gov/Archives/edgar/data/874015/000114036120028770/0001140361-20-028770-index.htm","us_notice_code":"Form 8-K","us_title_en":"Item 1.01: Entry into a Material Definitive Agreement;\nItem 5.02: Departure of Directors or Certain Officers; Election of Directors; Appointment of Certain Officers: Compensatory Arrangements of Certain Officers;\nItem 9.01: Financial Statements and Exhibits","is_important":0,"hasEarnInfos":false,"gpt_zh_title":"","gpt_en_title":"","attachments":[{"description":"EXHIBIT 99.1","seq":1,"linkUrl":"https://www.sec.gov/Archives/edgar/data/874015/000114036120028770/brhc10018098_ex99-1.htm","primary":true,"translateUrl":null,"linkName":"brhc10018098_ex99-1.htm","type":"EX-99.1","id":"NTFILEFEwJRcqPx56qqDYh","market":"us","size":9443},{"description":"8-K","seq":2,"linkUrl":"https://www.sec.gov/Archives/edgar/data/874015/000114036120028770/brhc10018098_8k.htm","primary":false,"translateUrl":null,"linkName":"brhc10018098_8k.htm","type":"8-K","id":"NTFILEHG5kewdznATPkAZH","market":"us","size":26566},{"description":"","seq":6,"linkUrl":"https://www.sec.gov/Archives/edgar/data/874015/000114036120028770/image0.jpg","primary":false,"translateUrl":null,"linkName":"image0.jpg","type":"GRAPHIC","id":"NTFILE8YM32YqfSnhgsExc","market":"us","size":11357}],"type_name":"交易披露","type_name_en":"Transaction Related","titleTypeEn":"Major Issues Report","us_type":"usAnnouncement","us_type_zh":"交易披露","earn_infos":[],"event_type":"important_notice","event_name":"重要事件披露","pubTime":"2020-12-18 00:00","pubTimestamp":1608220800,"title_zh":"8-K - Current report","summary_en":"Item 1.01: Entry into a Material Definitive Agreement;\nItem 5.02: Departure of Directors or Certain Officers; Election of Directors; Appointment of Certain Officers: Compensatory Arrangements of Certain Officers;\nItem 9.01: Financial Statements and Exhibits","summary_zh":"第1.01項:訂立實質性最終協議；第5.02項:董事或某些官員離職；選舉董事；某些官員的任命:某些官員的補償安排；項目9.01:財務報表和報表","notice_type":"","filling_tag":"","gpt_icon":0},{"cdn_pdf":false,"hasAttachments":true,"id":"11100041","market":"us","labels":[],"media":"sec.gov","original_id":"AN114036120027746-IONS","pdf_url":null,"pub_time":1607443200000,"showTitleType":true,"size":0,"source":"sec_us","summary":"8-K - Current report","symbol":"IONS","title":"8-K - Current report","titleType":"重要事件披露","type":"usAnnouncement","url":"https://www.sec.gov/Archives/edgar/data/874015/000114036120027746/0001140361-20-027746-index.htm","us_notice_code":"Form 8-K","us_title_en":"Item 8.01: Other Events;\nItem 9.01: Financial Statements and Exhibits","is_important":0,"hasEarnInfos":false,"gpt_zh_title":"","gpt_en_title":"","attachments":[{"description":"EXHIBIT 99.1","seq":1,"linkUrl":"https://www.sec.gov/Archives/edgar/data/874015/000114036120027746/brhc10017778_ex99-1.htm","primary":true,"translateUrl":null,"linkName":"brhc10017778_ex99-1.htm","type":"EX-99.1","id":"NTFILED3D1nBeToz7pmn6V","market":"us","size":36658},{"description":"8-K","seq":2,"linkUrl":"https://www.sec.gov/Archives/edgar/data/874015/000114036120027746/brhc10017778_8k.htm","primary":false,"translateUrl":null,"linkName":"brhc10017778_8k.htm","type":"8-K","id":"NTFILE3Um6izhQMAzhKUA5","market":"us","size":27296},{"description":"","seq":6,"linkUrl":"https://www.sec.gov/Archives/edgar/data/874015/000114036120027746/image0.jpg","primary":false,"translateUrl":null,"linkName":"image0.jpg","type":"GRAPHIC","id":"NTFILEG5CXTduPTzwD3WMx","market":"us","size":11357}],"type_name":"交易披露","type_name_en":"Transaction Related","titleTypeEn":"Major Issues Report","us_type":"usAnnouncement","us_type_zh":"交易披露","earn_infos":[],"event_type":"important_notice","event_name":"重要事件披露","pubTime":"2020-12-09 00:00","pubTimestamp":1607443200,"title_zh":"8-K - Current report","summary_en":"Item 8.01: Other Events;\nItem 9.01: Financial Statements and Exhibits","summary_zh":"項目8.01:其他活動；項目9.01:財務報表和報表","notice_type":"","filling_tag":"","gpt_icon":0},{"cdn_pdf":false,"hasAttachments":true,"id":"10725268","market":"us","labels":[],"media":"sec.gov","original_id":"AN87401520000142-IONS","pdf_url":null,"pub_time":1604419200000,"showTitleType":true,"size":0,"source":"sec_us","summary":"10-Q - Quarterly report [Sections 13 or 15(d)]","symbol":"IONS","title":"10-Q - Quarterly report [Sections 13 or 15(d)]","titleType":"季度報告","type":"usFinancials","url":"https://www.sec.gov/Archives/edgar/data/874015/000087401520000142/0000874015-20-000142-index.htm","us_notice_code":"Form 10-Q","us_title_en":"10-Q - Quarterly report [Sections 13 or 15(d)]","is_important":0,"hasEarnInfos":true,"gpt_zh_title":"","gpt_en_title":"","attachments":[{"description":"IONIS PHARMACEUTICALS INC 10-Q 9-30-2020","seq":1,"linkUrl":"https://www.sec.gov/Archives/edgar/data/874015/000087401520000142/form10q.htm","primary":true,"translateUrl":null,"linkName":"form10q.htm","type":"10-Q","id":"NTFILEHQ985opxzCEcLYMR","market":"us","size":2670664},{"description":"EXHIBIT 31.1","seq":2,"linkUrl":"https://www.sec.gov/Archives/edgar/data/874015/000087401520000142/ex31_1.htm","primary":false,"translateUrl":null,"linkName":"ex31_1.htm","type":"EX-31.1","id":"NTFILEFuFMiLnVQCzJ7toF","market":"us","size":13547},{"description":"EXHIBIT 31.2","seq":3,"linkUrl":"https://www.sec.gov/Archives/edgar/data/874015/000087401520000142/ex31_2.htm","primary":false,"translateUrl":null,"linkName":"ex31_2.htm","type":"EX-31.2","id":"NTFILEJ6uApu6jqtqZiqDj","market":"us","size":13464},{"description":"EXHIBIT 32.1","seq":4,"linkUrl":"https://www.sec.gov/Archives/edgar/data/874015/000087401520000142/ex32_1.htm","primary":false,"translateUrl":null,"linkName":"ex32_1.htm","type":"EX-32.1","id":"NTFILEDVRyQzfRxs7eMGvC","market":"us","size":7023}],"type_name":"財務報告","type_name_en":"Financial Report","titleTypeEn":"Quarterly Report","us_type":"usFinancials","us_type_zh":"財務報告","earn_infos":[{"id":47944,"name":"CONDENSED CONSOLIDATED BALANCE SHEETS (Unaudited)","name_zh":null,"url":"https://www.sec.gov/Archives/edgar/data/874015/000087401520000142/R2.htm","cdn_url":"","translation_url":"","translate_status":0},{"id":47945,"name":"CONDENSED CONSOLIDATED BALANCE SHEETS (Unaudited) (Parenthetical)","name_zh":null,"url":"https://www.sec.gov/Archives/edgar/data/874015/000087401520000142/R3.htm","cdn_url":"","translation_url":"","translate_status":0},{"id":47946,"name":"CONDENSED CONSOLIDATED STATEMENTS OF OPERATIONS (Unaudited)","name_zh":null,"url":"https://www.sec.gov/Archives/edgar/data/874015/000087401520000142/R4.htm","cdn_url":"","translation_url":"","translate_status":0},{"id":47947,"name":"CONDENSED CONSOLIDATED STATEMENTS OF COMPREHENSIVE INCOME (LOSS) (Unaudited)","name_zh":null,"url":"https://www.sec.gov/Archives/edgar/data/874015/000087401520000142/R5.htm","cdn_url":"","translation_url":"","translate_status":0},{"id":47948,"name":"CONDENSED CONSOLIDATED STATEMENTS OF STOCKHOLDERS' EQUITY (Unaudited)","name_zh":null,"url":"https://www.sec.gov/Archives/edgar/data/874015/000087401520000142/R6.htm","cdn_url":"","translation_url":"","translate_status":0},{"id":47949,"name":"CONDENSED CONSOLIDATED STATEMENTS OF CASH FLOWS (Unaudited)","name_zh":"簡明合併現金流量表（未經審計）","url":"https://www.sec.gov/Archives/edgar/data/874015/000087401520000142/R7.htm","cdn_url":"https://static.tigerbbs.com/3b7fe9c2ff49bf26bec185b55c4a2512","translation_url":"https://static.tigerbbs.com/05d98c42fde2bed64b38fefcd3d19711","translate_status":1}],"event_type":"important_notice","event_name":"季度報告","pubTime":"2020-11-04 00:00","pubTimestamp":1604419200,"title_zh":"10-Q - Quarterly report [Sections 13 or 15(d","summary_en":"","summary_zh":"","notice_type":"","filling_tag":"","gpt_icon":0},{"cdn_pdf":false,"hasAttachments":true,"id":"10723061","market":"us","labels":[],"media":"sec.gov","original_id":"AN114036120024494-IONS","pdf_url":null,"pub_time":1604419200000,"showTitleType":true,"size":0,"source":"sec_us","summary":"8-K - Current report","symbol":"IONS","title":"8-K - Current report","titleType":"重要事件披露","type":"usAnnouncement","url":"https://www.sec.gov/Archives/edgar/data/874015/000114036120024494/0001140361-20-024494-index.htm","us_notice_code":"Form 8-K","us_title_en":"Item 2.02: Results of Operations and Financial Condition;\nItem 9.01: Financial Statements and Exhibits","is_important":0,"hasEarnInfos":false,"gpt_zh_title":"","gpt_en_title":"","attachments":[{"description":"EXHIBIT 99.1","seq":1,"linkUrl":"https://www.sec.gov/Archives/edgar/data/874015/000114036120024494/brhc10016584_99-1.htm","primary":true,"translateUrl":null,"linkName":"brhc10016584_99-1.htm","type":"EX-99.1","id":"NTFILE9Rif3vrHh8BkFA7W","market":"us","size":453244},{"description":"8-K","seq":2,"linkUrl":"https://www.sec.gov/Archives/edgar/data/874015/000114036120024494/brhc10016584_8k.htm","primary":false,"translateUrl":null,"linkName":"brhc10016584_8k.htm","type":"8-K","id":"NTFILEG3cz2XVcNCadyHqF","market":"us","size":25088},{"description":"","seq":6,"linkUrl":"https://www.sec.gov/Archives/edgar/data/874015/000114036120024494/image00001.jpg","primary":false,"translateUrl":null,"linkName":"image00001.jpg","type":"GRAPHIC","id":"NTFILE5RhDZKL4gvS6dHvv","market":"us","size":4803}],"type_name":"交易披露","type_name_en":"Transaction Related","titleTypeEn":"Major Issues Report","us_type":"usAnnouncement","us_type_zh":"交易披露","earn_infos":[],"event_type":"important_notice","event_name":"重要事件披露","pubTime":"2020-11-04 00:00","pubTimestamp":1604419200,"title_zh":"8-K - Current report","summary_en":"Item 2.02: Results of Operations and Financial Condition;\nItem 9.01: Financial Statements and Exhibits","summary_zh":"第2.02項:經營成果和財務狀況；項目9.01:財務報表和報表","notice_type":"","filling_tag":"","gpt_icon":0}],"pageSize":20,"totalPage":20,"pageCount":15,"totalSize":395,"code":"91000000","status":"200"}]}}