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思科

57.34

+0.50000.88%

盘后：57.360.0191+0.03%19:49 EDT

成交量：1,346.61万

成交额：7.71亿

市值：2,281.15亿

市盈率：25.19

高：57.49

开：56.69

低：56.63

收：56.84

数据加载中...

总览公司新闻公告

罗博特科：美国关税政策对ficonTEC光模块设备影响很小或基本没有影响

思科4月29日成交额为7.71亿美元

Arista Networks 第一季度预览：人工智能驱动的负载平衡和可观察性

美股研究社

思科4月25日成交额为9.33亿美元

思科4月24日成交额为12.80亿美元

思科4月23日成交额为16.95亿美元

思科盘中异动早盘股价大涨3.00%报56.69美元

Rosenblatt：维持Cisco Systems(CSCO.US)评级，由买入调整至买入评级, 目标价由80.00美元调整至63.00美元。

海思科：范秀莲质押480万股，占总股本0.43%

思科盘中异动股价大跌3.00%报54.09美元

2025 CSCO指南更新：亚盛医药-B(06855)APG-2575首获推荐耐立克®获升级推荐

摩根大通下调思科目标价至70美元

思科4月17日成交额为8.91亿美元

摩根大通：将思科(CSCO.O)的目标价由73美元下调至70美元。

思科4月16日成交额为11.53亿美元

思科盘中异动快速跳水3.01%报55.48美元

CD38单抗破局，如何重塑多发性骨髓瘤治疗版图？｜21CC肿瘤周

21世纪经济报道

思科4月15日成交额为10.64亿美元

谷歌垃圾邮件政策遭德国媒体公司欧盟反垄断投诉

当乳腺癌诊疗邂逅AI，中国能否率先叩开精准智能均质时代大门？

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09:24","pubTimestamp":1745630650,"startTime":"0","endTime":"0","summary":"美东时间2025年4月25日，思科成交额为9.33亿美元，成交额较昨日减少27.12%，当日成交量为1649.38万股。思科于2025年4月25日涨0.75%，报56.71美元，该股过去5个交易日涨1.7%，年初至今跌2.91%，过去60日跌4.14%。|近5个交易日成交情况||||#|日期|成交额（美元）|成交额较昨日变化|成交量（股）|#|2025-04-25|9.33亿|-27.12%|1649.38万|#|2025-04-24|12.80亿|-24.48%|2278.23万|#|2025-04-23|16.95亿|54.37%|3023.15万|#|2025-04-22|10.98亿|29.64%|1996.18万|#|2025-04-21|8.47亿|-4.96%|1557.88万|思科系统是全球最大的网络设备供应商，也是全球最大的软件公司之一。总体而言，思科拥有 80000 名员工，其产品面向全球销售。","market":"us","thumbnail":null,"type":0,"news_type":0,"thumbnails":[],"rights":{"source":"tencent","url":"http://gu.qq.com/resources/shy/news/detail-v2/index.html#/?id=nesSN20250426092420a6c8c5a8&s=b","rn_cache_url":null,"customStyle":"body{padding-top:10px;}#news_title{font-weight:bold;#titleStyle#;}#news_description span{font-size:12px;#descriptionStyle#;}.footer-note{#statement#}","selectors":".mod-LoadTzbdNews, body","filters":".relate-stock, .hot-list, .recom-box, 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09:23","pubTimestamp":1745544223,"startTime":"0","endTime":"0","summary":"美东时间2025年4月24日，思科成交额为12.80亿美元，成交额较昨日减少24.48%，当日成交量为2278.23万股。思科于2025年4月24日涨1.19%，报56.29美元，该股过去5个交易日涨0.95%，年初至今跌3.63%，过去60日跌4.65%。|近5个交易日成交情况||||#|日期|成交额（美元）|成交额较昨日变化|成交量（股）|#|2025-04-24|12.80亿|-24.48%|2278.23万|#|2025-04-23|16.95亿|54.37%|3023.15万|#|2025-04-22|10.98亿|29.64%|1996.18万|#|2025-04-21|8.47亿|-4.96%|1557.88万|#|2025-04-17|8.91亿|-22.68%|1591.04万|思科系统是全球最大的网络设备供应商，也是全球最大的软件公司之一。总体而言，思科拥有 80000 名员工，其产品面向全球销售。","market":"us","thumbnail":null,"type":0,"news_type":0,"thumbnails":[],"rights":{"source":"tencent","url":"http://gu.qq.com/resources/shy/news/detail-v2/index.html#/?id=nesSN20250425092349a6c75772&s=b","rn_cache_url":null,"customStyle":"body{padding-top:10px;}#news_title{font-weight:bold;#titleStyle#;}#news_description span{font-size:12px;#descriptionStyle#;}.footer-note{#statement#}","selectors":".mod-LoadTzbdNews, body","filters":".relate-stock, .hot-list, .recom-box, 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09:23","pubTimestamp":1745457787,"startTime":"0","endTime":"0","summary":"美东时间2025年4月23日，思科成交额为16.95亿美元，成交额较昨日增加54.37%，当日成交量为3023.15万股。思科于2025年4月23日涨1.07%，报55.63美元，该股过去5个交易日跌2.74%，年初至今跌4.76%，过去60日跌5.21%。|近5个交易日成交情况||||#|日期|成交额（美元）|成交额较昨日变化|成交量（股）|#|2025-04-23|16.95亿|54.37%|3023.15万|#|2025-04-22|10.98亿|29.64%|1996.18万|#|2025-04-21|8.47亿|-4.96%|1557.88万|#|2025-04-17|8.91亿|-22.68%|1591.04万|#|2025-04-16|11.53亿|8.35%|2055.13万|思科系统是全球最大的网络设备供应商，也是全球最大的软件公司之一。总体而言，思科拥有 80000 名员工，其产品面向全球销售。","market":"us","thumbnail":null,"type":0,"news_type":0,"thumbnails":[],"rights":{"source":"tencent","url":"http://gu.qq.com/resources/shy/news/detail-v2/index.html#/?id=nesSN20250424092312a6c5de14&s=b","rn_cache_url":null,"customStyle":"body{padding-top:10px;}#news_title{font-weight:bold;#titleStyle#;}#news_description span{font-size:12px;#descriptionStyle#;}.footer-note{#statement#}","selectors":".mod-LoadTzbdNews, body","filters":".relate-stock, .hot-list, .recom-box, 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早盘股价大涨3.00%报56.69美元","url":"https://stock-news.laohu8.com/highlight/detail?id=2529684728","media":"市场透视","labels":[],"top":-1,"itemType":null,"share":"https://ttm.financial/m/news/2529684728?lang=zh_cn&edition=fundamental","pubTime":"2025-04-23 21:38","pubTimestamp":1745415498,"startTime":"0","endTime":"0","summary":"北京时间2025年04月23日21时38分，思科股票出现异动，股价快速上涨3.00%。截至发稿，该股报56.69美元/股，成交量549.186万股，换手率0.14%，振幅1.20%。思科股票所在的通讯公司行业中，整体涨幅为1.84%。总体而言，思科拥有 80000 名员工，其产品面向全球销售。消息层面，截至21时38分，《Rosenblatt：维持Cisco Systems评级，由买入调整至买入评级, 目标价由80.00美元调整至63.00美元。》资讯为影响思科的重要信息。","market":"us","thumbnail":null,"type":0,"news_type":0,"thumbnails":[],"rights":{"source":"tencent","url":"http://gu.qq.com/resources/shy/news/detail-v2/index.html#/?id=nesSN20250423213818a463fc35&s=b","rn_cache_url":null,"customStyle":"body{padding-top:10px;}#news_title{font-weight:bold;#titleStyle#;}#news_description span{font-size:12px;#descriptionStyle#;}.footer-note{#statement#}","selectors":".mod-LoadTzbdNews, 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Systems(CSCO.US)评级，由买入调整至买入评级, 目标价由80.00美元调整至63.00美元。","url":"https://stock-news.laohu8.com/highlight/detail?id=2529688605","media":"金融界","labels":[],"top":-1,"itemType":null,"share":"https://ttm.financial/m/news/2529688605?lang=zh_cn&edition=fundamental","pubTime":"2025-04-23 04:48","pubTimestamp":1745354881,"startTime":"0","endTime":"0","summary":"Rosenblatt：维持Cisco Systems(CSCO.US)评级，由买入调整至买入评级, 目标价由80.00美元调整至63.00美元。","market":"hk","thumbnail":"","type":0,"news_type":0,"thumbnails":[],"rights":null,"property":["rate"],"language":"zh","translate_title":"","themeId":null,"theme_name":"","theme_type":"","isJumpTheme":false,"source_url":"https://24h.jrj.com.cn/2025/04/23044849771799.shtml","is_publish_highlight":false,"source_rank":0,"column":"","sentiment":"0","news_top_title":null,"news_tag":"","news_rank":0,"length":0,"strategy_id":0,"source":"jinrongjie_stock","symbols":["CSCO"],"gpt_icon":0},{"id":"2529581909","title":"海思科：范秀莲质押480万股，占总股本0.43%","url":"https://stock-news.laohu8.com/highlight/detail?id=2529581909","media":"公司公告","labels":[],"top":-1,"itemType":null,"share":"https://ttm.financial/m/news/2529581909?lang=zh_cn&edition=fundamental","pubTime":"2025-04-22 20:29","pubTimestamp":1745324948,"startTime":"0","endTime":"0","summary":"海 思科 公告，股东范秀莲质押480万股，占其所持股份比例2.21%，占公司总股本比例0.43%。本次质押后，范秀莲累计质押股份数量为5,871万股，占其所持股份比例27.02%，占公司总股本比例5.24%。截至公告披露日，范秀莲及其一致行动人合计质押股份数量为5,871万股，占其所持股份比例22.60%，占公司总股本比例5.24%。","market":"us","thumbnail":null,"type":0,"news_type":0,"thumbnails":[],"rights":{"source":"tencent","url":"http://gu.qq.com/resources/shy/news/detail-v2/index.html#/?id=nesSN20250422203954a4627b30&s=b","rn_cache_url":null,"customStyle":"body{padding-top:10px;}#news_title{font-weight:bold;#titleStyle#;}#news_description span{font-size:12px;#descriptionStyle#;}.footer-note{#statement#}","selectors":".mod-LoadTzbdNews, body","filters":".relate-stock, .hot-list, .recom-box, 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01:14","pubTimestamp":1745255661,"startTime":"0","endTime":"0","summary":"北京时间2025年04月22日01时14分，思科股票出现波动，股价大幅下跌3.00%。截至发稿，该股报54.09美元/股，成交量506.303万股，换手率0.13%，振幅2.20%。最近的财报数据显示，该股实现营业收入139.91亿美元，净利润24.28亿美元，每股收益0.61美元，毛利88.46亿美元，市盈率23.74倍。思科股票所在的通讯公司行业中，整体跌幅为2.89%。总体而言，思科拥有 80000 名员工，其产品面向全球销售。","market":"us","thumbnail":null,"type":0,"news_type":0,"thumbnails":[],"rights":{"source":"tencent","url":"http://gu.qq.com/resources/shy/news/detail-v2/index.html#/?id=nesSN20250422011422a6c2ab3f&s=b","rn_cache_url":null,"customStyle":"body{padding-top:10px;}#news_title{font-weight:bold;#titleStyle#;}#news_description span{font-size:12px;#descriptionStyle#;}.footer-note{#statement#}","selectors":".mod-LoadTzbdNews, body","filters":".relate-stock, .hot-list, .recom-box, 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CSCO指南更新：亚盛医药-B(06855)APG-2575首获推荐 耐立克®获升级推荐","url":"https://stock-news.laohu8.com/highlight/detail?id=2529877876","media":"智通财经","labels":["productRelease"],"top":-1,"itemType":null,"share":"https://ttm.financial/m/news/2529877876?lang=zh_cn&edition=fundamental","pubTime":"2025-04-21 19:26","pubTimestamp":1745234776,"startTime":"0","endTime":"0","summary":"智通财经APP讯，亚盛医药-B 发布公告，公司自主研发的两款重磅创新药均获纳入2025年中国临床肿瘤学会系列指南：在研品种新型口服 Bcl-2选择性抑制剂Lisaftoclax首次获《CSCO淋巴瘤诊疗指南》推荐。2024年11月，Lisaftoclax单药治疗R/R CLL/SLL的NDA申请已获国家药监局药品审评中心受理并纳入优先审评。此次2025版《 CSCO儿童及青少年白血病诊疗指南》在针对费城染色体阳性急性淋巴细胞白血病儿童患者的治疗中，首次将奥雷巴替尼升级为I级推荐治疗方案用于BCR-ABL1激酶区T315I突变患者。","market":"us","thumbnail":null,"type":0,"news_type":0,"thumbnails":[],"rights":null,"property":[],"language":"zh","translate_title":"","themeId":null,"theme_name":"","theme_type":"","isJumpTheme":false,"source_url":"http://www.zhitongcaijing.com/content/detail/1281643.html","is_publish_highlight":false,"source_rank":0,"column":"","sentiment":"1","news_top_title":null,"news_tag":"productRelease","news_rank":0,"length":0,"strategy_id":0,"source":"stock_zhitongcaijing","symbols":["BK4533","BK4534","LU1059921491.USD","LU1571399168.USD","CSCO","LU1880398471.USD","BK4020","IE00BSNM7G36.USD","IE00BVYPNV92.GBP","LU1244550577.SGD","SG9999015952.SGD","BK1574","SG9999001440.SGD","LU2237443382.USD","LU2237443978.SGD","LU0889566641.SGD","LU1235294995.USD","06855","LU0234572021.USD","LU1880398554.USD","LU0348723411.USD","AAPG","IE00BFXG1179.USD","LU1599440770.SGD","LU2237443895.HKD","LU0234570918.USD","LU0731783394.SGD","LU2125909916.SGD","SG9999015986.USD","APG","BK4550","BK4560","LU1430594728.SGD","BK4527","BK4525","LU0203345920.USD","IE00BGHQF631.EUR","IE00BVYPNW00.USD","LU1585245621.USD","BK4579","LU1506573853.SGD","SG9999015945.SGD","LU1066051225.USD","LU2237443622.USD","LU1046421795.USD","LU2237443549.SGD","BK4581","IE00B3T34201.USD","LU0792757196.USD","LU0823417737.USD"],"gpt_icon":0},{"id":"2528300035","title":"摩根大通下调思科目标价至70美元","url":"https://stock-news.laohu8.com/highlight/detail?id=2528300035","media":"格隆汇","labels":[],"top":-1,"itemType":null,"share":"https://ttm.financial/m/news/2528300035?lang=zh_cn&edition=fundamental","pubTime":"2025-04-18 15:06","pubTimestamp":1744960014,"startTime":"0","endTime":"0","summary":"摩根大通将思科的目标价从73美元下调至70美元，维持“增持”评级。(格隆汇)","market":"hk","thumbnail":"","type":0,"news_type":0,"thumbnails":[],"rights":null,"property":["rate"],"language":"zh","translate_title":"","themeId":null,"theme_name":"","theme_type":"","isJumpTheme":false,"source_url":"https://finance.jrj.com.cn/2025/04/18150649653226.shtml","is_publish_highlight":false,"source_rank":0,"column":"","sentiment":"-1","news_top_title":null,"news_tag":"","news_rank":0,"length":0,"strategy_id":0,"source":"jinrongjie_stock","symbols":["CSCO"],"gpt_icon":0},{"id":"2528704132","title":"思科4月17日成交额为8.91亿美元","url":"https://stock-news.laohu8.com/highlight/detail?id=2528704132","media":"市场透视","labels":[],"top":-1,"itemType":null,"share":"https://ttm.financial/m/news/2528704132?lang=zh_cn&edition=fundamental","pubTime":"2025-04-18 09:24","pubTimestamp":1744939449,"startTime":"0","endTime":"0","summary":"美东时间2025年4月17日，思科成交额为8.91亿美元，成交额较昨日减少22.68%，当日成交量为1591.04万股。思科于2025年4月17日涨0.0%，报55.76美元，该股过去5个交易日跌1.47%，年初至今跌4.54%，过去60日跌8.92%。|近5个交易日成交情况||||#|日期|成交额（美元）|成交额较昨日变化|成交量（股）|#|2025-04-17|8.91亿|-22.68%|1591.04万|#|2025-04-16|11.53亿|8.35%|2055.13万|#|2025-04-15|10.64亿|17.97%|1854.36万|#|2025-04-14|9.02亿|-31.54%|1565.77万|#|2025-04-11|13.17亿|-27.15%|2303.69万|思科系统是全球最大的网络设备供应商，也是全球最大的软件公司之一。总体而言，思科拥有 80000 名员工，其产品面向全球销售。","market":"us","thumbnail":null,"type":0,"news_type":0,"thumbnails":[],"rights":{"source":"tencent","url":"http://gu.qq.com/resources/shy/news/detail-v2/index.html#/?id=nesSN20250418092415a45d3d30&s=b","rn_cache_url":null,"customStyle":"body{padding-top:10px;}#news_title{font-weight:bold;#titleStyle#;}#news_description span{font-size:12px;#descriptionStyle#;}.footer-note{#statement#}","selectors":".mod-LoadTzbdNews, body","filters":".relate-stock, .hot-list, .recom-box, 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17:22","pubTimestamp":1744881750,"startTime":"0","endTime":"0","summary":null,"market":"us","thumbnail":null,"type":0,"news_type":0,"thumbnails":[],"rights":null,"property":[],"language":"zh","translate_title":"","themeId":null,"theme_name":"","theme_type":"","isJumpTheme":false,"source_url":"https://www.ushknews.com/","is_publish_highlight":false,"source_rank":0,"column":"","sentiment":"0","news_top_title":null,"news_tag":"","news_rank":0,"length":0,"strategy_id":0,"source":"live_meigang","symbols":["LU2506951875.HKD","BK4020","LU2237443549.SGD","LU1823568750.SGD","IE00BFMHRM44.USD","LU1059921491.USD","LU1894683348.USD","LU1571399168.USD","IE00BKVL7J92.USD","BK4585","IE00B42XCP33.USD","LU1430594728.SGD","BK4525","SG9999002224.SGD","LU0348723411.USD","BK4581","CSCO","LU0823417737.USD","LU1066053197.SGD","LU1880398471.USD","IE00BSNM7G36.USD","LU0234570918.USD","SG9999015986.USD","IE00B3T34201.USD","LU2247934214.USD","LU1066051225.USD","LU0234572021.USD","SG9999002232.USD","LU1585245621.USD","IE00BDGV0183.EUR","LU1894683264.USD","IE00BVYPNW00.USD","IE00BVYPNV92.GBP","LU2506952097.USD","LU0868494708.USD","LU1506573853.SGD","LU0731783394.SGD","SG9999015978.USD","LU2237443382.USD","LU0792757196.USD","BK4515","BK4612","LU1244550577.SGD","LU0950375773.USD","LU2506951958.HKD","BK4579","LU1880398554.USD","LU1267930813.SGD","IE00B3PB1722.GBP","LU0203345920.USD"],"gpt_icon":0},{"id":"2528780036","title":"思科4月16日成交额为11.53亿美元","url":"https://stock-news.laohu8.com/highlight/detail?id=2528780036","media":"市场透视","labels":[],"top":-1,"itemType":null,"share":"https://ttm.financial/m/news/2528780036?lang=zh_cn&edition=fundamental","pubTime":"2025-04-17 09:22","pubTimestamp":1744852977,"startTime":"0","endTime":"0","summary":"美东时间2025年4月16日，思科成交额为11.53亿美元，成交额较昨日增加8.35%，当日成交量为2055.13万股。思科于2025年4月16日跌2.52%，报55.76美元，该股过去5个交易日跌4.08%，年初至今跌4.54%，过去60日跌8.03%。|近5个交易日成交情况||||#|日期|成交额（美元）|成交额较昨日变化|成交量（股）|#|2025-04-16|11.53亿|8.35%|2055.13万|#|2025-04-15|10.64亿|17.97%|1854.36万|#|2025-04-14|9.02亿|-31.54%|1565.77万|#|2025-04-11|13.17亿|-27.15%|2303.69万|#|2025-04-10|18.08亿|-39.93%|3196.46万|思科系统是全球最大的网络设备供应商，也是全球最大的软件公司之一。总体而言，思科拥有 80000 名员工，其产品面向全球销售。","market":"us","thumbnail":null,"type":0,"news_type":0,"thumbnails":[],"rights":{"source":"tencent","url":"http://gu.qq.com/resources/shy/news/detail-v2/index.html#/?id=nesSN20250417092309a6bd3baa&s=b","rn_cache_url":null,"customStyle":"body{padding-top:10px;}#news_title{font-weight:bold;#titleStyle#;}#news_description span{font-size:12px;#descriptionStyle#;}.footer-note{#statement#}","selectors":".mod-LoadTzbdNews, body","filters":".relate-stock, .hot-list, .recom-box, 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快速跳水3.01%报55.48美元","url":"https://stock-news.laohu8.com/highlight/detail?id=2528227420","media":"市场透视","labels":[],"top":-1,"itemType":null,"share":"https://ttm.financial/m/news/2528227420?lang=zh_cn&edition=fundamental","pubTime":"2025-04-17 03:25","pubTimestamp":1744831516,"startTime":"0","endTime":"0","summary":"北京时间2025年04月17日03时25分，思科股票出现异动，股价快速跳水3.01%。截至发稿，该股报55.48美元/股，成交量1083.03万股，换手率0.27%，振幅2.77%。思科股票所在的通讯公司行业中，整体跌幅为2.81%。总体而言，思科拥有 80000 名员工，其产品面向全球销售。消息层面，截至03时25分，《花旗：维持Cisco Systems评级，由买入调整至买入评级, 目标价由73.00美元调整至68.00美元。》资讯为影响思科的重要信息。","market":"us","thumbnail":null,"type":0,"news_type":0,"thumbnails":[],"rights":{"source":"tencent","url":"http://gu.qq.com/resources/shy/news/detail-v2/index.html#/?id=nesSN20250417032516973a4010&s=b","rn_cache_url":null,"customStyle":"body{padding-top:10px;}#news_title{font-weight:bold;#titleStyle#;}#news_description span{font-size:12px;#descriptionStyle#;}.footer-note{#statement#}","selectors":".mod-LoadTzbdNews, body","filters":".relate-stock, 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09:24","pubTimestamp":1744766662,"startTime":"0","endTime":"0","summary":"编者按：2025年4月15日—21日是第31个全国肿瘤防治宣传周，今年宣传主题为“科学防癌健康生活”，旨在通过普及癌症防治科学知识，倡导群众践行健康生活方式，控制癌症风险因素；鼓励高风险人群主动参加癌症筛查，促进早诊早治；指导癌症患者及时接受规范化诊疗，并定期复查。通过全过程全生命周期健康管理，更好满足人民群众健康需求，保障人民群众健康生活。","market":"us","thumbnail":null,"type":0,"news_type":0,"thumbnails":[],"rights":{"source":"stock_eastmoney","url":"http://finance.eastmoney.com/a/202504163378198872.html","rn_cache_url":null,"directOrigin":true},"property":[],"language":"zh","translate_title":"","themeId":null,"theme_name":"","theme_type":"","isJumpTheme":false,"source_url":"http://finance.eastmoney.com/a/202504163378198872.html","is_publish_highlight":false,"source_rank":0,"column":"","sentiment":"0","news_top_title":null,"news_tag":"","news_rank":0,"length":0,"strategy_id":0,"source":"stock_eastmoney","symbols":["LU1235294995.USD","BK4585","SG9999015986.USD","BK4020","LU1059921491.USD","BK4560","BK4581","LU0234572021.USD","LU1894683348.USD","LU1585245621.USD","CSCO","LU0942090050.USD","LU2237443978.SGD","LU2506952097.USD","LU1880398554.USD","IE00BFMHRM44.USD","LU1066051811.HKD","SG9999002224.SGD","PFS","IE00BFXG1179.USD","LU0823417737.USD","LU2247934214.USD","IE00BKVL7J92.USD","IE00BGHQF631.EUR","LU0234570918.USD","LU2237443622.USD","LU0792757196.USD","IE00B42XCP33.USD","LU2237443465.HKD","LU1244550577.SGD","LU2506951875.HKD","LU0203347892.USD","SG9999015945.SGD","BK4550","BK4080","LU0731783394.SGD","LU1046421795.USD","SG9999015952.SGD","BK4195","BK4525","LU1066053197.SGD","LU2237443549.SGD","BK4211","LU1430594728.SGD","LU1883839398.USD","LU2237443382.USD","LU1571399168.USD","SG9999002232.USD","ADC","LU1823568750.SGD"],"gpt_icon":0},{"id":"2527372404","title":"思科4月15日成交额为10.64亿美元","url":"https://stock-news.laohu8.com/highlight/detail?id=2527372404","media":"市场透视","labels":[],"top":-1,"itemType":null,"share":"https://ttm.financial/m/news/2527372404?lang=zh_cn&edition=fundamental","pubTime":"2025-04-16 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