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SPYRE THERAPEUTICS INC

89.33

-1.0300-1.14%

盘后：89.330.00000.00%19:30 EDT

成交量：191.32万

成交额：1.70亿

市值：78.77亿

市盈率：-44.44

高：90.97

开：89.15

低：86.40

收：90.36

52周最高：110.18

52周最低：14.51

股本：8,817.38万

流通股本：8,097.70万

量比：1.35

换手率：2.36%

股息：- -

股息率：- -

每股收益(TTM):-2.0100

每股收益(LYR):-1.9755

净资产收益率：-22.98%

总资产收益率：-19.81%

市净率：8.25

市盈率(LYR):-45.22

数据加载中...

总览公司新闻公告

BUZZ——美国股市动态-Semtech、唐纳森、Meta

Spyre股价下跌，因关节炎药物未达研发目标

Spyre Therapeutics盘前股价重挫12.4% 实验性药物未达类风湿关节炎单药治疗开发门槛

Spyre Therapeutics公司——疗效幅度未达公司预设目标，类风湿关节炎候选药物SPY072单药疗法开发优先级或将调整

Spyre Therapeutics公司：Spy072联合Il17-a/F治疗化脓性汗腺炎（HS）预计于2027年末或2028年初启动

Spyre Therapeutics——Spy072在多项终点指标上较安慰剂展现统计学显著优势

Spyre Therapeutics公布Spy072 Skyway二期试验类风湿关节炎亚研究顶线结果

美国研究综述-Accendra Health、Celestica、Sionna Therapeutics

Spyre Therapeutics推出Spy772项目，启动化脓性汗腺炎SkyLight二期临床试验

异动解读｜Spyre Therapeutics盘中上涨11.41%，报104.42美元

异动解读｜Spyre Therapeutics盘中上涨5.02%，报93.505美元

异动解读｜SPYRE THERAPEUTICS盘前下跌5.04%，董事减持持续施压股价

异动解读｜Spyre Therapeutics盘中下跌14.76%，董事减持引发市场关注

异动解读｜SPYRE THERAPEUTICS盘前下跌10.83%，报86.54美元

异动解读｜SPYRE THERAPEUTICS夜盘下跌7.91%，报89.37美元

异动解读｜SPYRE THERAPEUTICS盘后上涨8.19%，报105.0美元

Spyre称，其肠道疾病药物在中期试验中显示出减轻炎症的效果

Spyre Therapeutics：二十名受试者出现治疗引发不良事件；两例严重，均与药物无关

SPYRE THERAPEUTICS：Spy002在第12周实现33%临床缓解与42%内镜改善

Spyre公布其潜在同类最佳药物Spy002（抗TL1A）在Skyline试验中治疗中重度溃疡性结肠炎患者的A部分诱导结果

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Therapeutics股价在盘前交易时段大幅下跌12.4%，此前该公司宣布其一款实验性药物未能达到类风湿关节炎单药治疗开发所需的疗效阈值。这一消息令市场投资者颇感意外，引发对该生物科技公司研发管线前景的重新评估。受此利空冲击，该股在常规交易开始前即遭遇显著抛售压力，反映出市场对候选药物临床价值的疑虑正在加深。分析人士指出，未能跨越预设的疗效门槛意味着该药物作为单一疗法的开发路径将面临重大调整，公司或需重新考量其战略布局。投资者正密切关注公司后续的研发决策及可能的替代方案。","market":"us","thumbnail":"","type":0,"news_type":0,"thumbnails":[],"rights":null,"property":[],"language":"zh","translate_title":"","themeId":null,"theme_name":"","theme_type":"","isJumpTheme":false,"source_url":"","is_publish_highlight":false,"source_rank":0,"column":"","sentiment":"-2","news_top_title":null,"news_tag":"","news_rank":0,"length":0,"strategy_id":0,"source":null,"symbols":["SYRE","LFSC","BK4139"],"isVideo":false,"video":null,"gpt_icon":0},{"id":"1158063890","title":"Spyre 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Therapeutics公司近日披露，其类风湿关节炎在研药物SPY072在临床试验中展现的疗效幅度未能达到公司预先设定的目标阈值。这一结果意味着，该公司此前规划的单药疗法开发路径——即将SPY072作为独立治疗方案推进的优先策略——如今面临重新审视与调整的现实压力。","market":"us","thumbnail":"","type":0,"news_type":0,"thumbnails":[],"rights":null,"property":[],"language":"zh","translate_title":"","themeId":null,"theme_name":"","theme_type":"","isJumpTheme":false,"source_url":"","is_publish_highlight":false,"source_rank":0,"column":"","sentiment":"-1","news_top_title":null,"news_tag":"dataReport","news_rank":0,"length":0,"strategy_id":0,"source":null,"symbols":["SYRE","LFSC","BK4139"],"isVideo":false,"video":null,"gpt_icon":0},{"id":"1107207144","title":"Spyre Therapeutics公司：Spy072联合Il17-a/F治疗化脓性汗腺炎（HS）预计于2027年末或2028年初启动","url":"https://stock-news.laohu8.com/highlight/detail?id=1107207144","media":"美股速递","labels":[],"top":-1,"itemType":null,"share":"https://ttm.financial/m/news/1107207144?lang=zh_cn&edition=fundamental","pubTime":"2026-08-26 04:02","pubTimestamp":1787688130,"startTime":"0","endTime":"0","summary":"Spyre Therapeutics Inc宣布，其候选药物Spy072与Il17-a/F联合疗法用于治疗化脓性汗腺炎（HS）的计划，预计将在2027年末或2028年初推进。这一时间表标志着该公司在炎症性疾病领域管线布局的重要节点，也反映出其对该联合方案临床开发节奏的审慎把控。","market":"us","thumbnail":"","type":0,"news_type":0,"thumbnails":[],"rights":null,"property":[],"language":"zh","translate_title":"","themeId":null,"theme_name":"","theme_type":"","isJumpTheme":false,"source_url":"","is_publish_highlight":false,"source_rank":0,"column":"","sentiment":"1","news_top_title":null,"news_tag":"","news_rank":0,"length":0,"strategy_id":0,"source":null,"symbols":["LFSC","SYRE","BK4139"],"isVideo":false,"video":null,"gpt_icon":0},{"id":"1157101849","title":"Spyre Therapeutics——Spy072在多项终点指标上较安慰剂展现统计学显著优势","url":"https://stock-news.laohu8.com/highlight/detail?id=1157101849","media":"美股速递","labels":["dataReport"],"top":-1,"itemType":null,"share":"https://ttm.financial/m/news/1157101849?lang=zh_cn&edition=fundamental","pubTime":"2026-08-26 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Therapeutics","url":"https://stock-news.laohu8.com/highlight/detail?id=2658998788","media":"路透中文","labels":[],"top":-1,"itemType":null,"share":"https://ttm.financial/m/news/2658998788?lang=zh_cn&edition=fundamental","pubTime":"2026-08-11 16:11","pubTimestamp":1786435905,"startTime":"0","endTime":"0","summary":"美国研究综述-Accendra Health、Celestica、Sionna Therapeutics路透8月11日-周二，华尔街证券分析师下调了多家在美国上市公司的评级和目标股价，其中包括Accendra Health、Celestica和Sionna Therapeutics。股票条目按字母顺序排列。","market":"us","thumbnail":null,"type":0,"news_type":0,"thumbnails":[],"rights":null,"property":[],"language":"zh","translate_title":"","themeId":null,"theme_name":"","theme_type":"","isJumpTheme":false,"source_url":"https://api.refinitiv.com/data/news/v1/stories/urn:newsml:reuters.com:20260811:nL4S4480H4:1","is_publish_highlight":false,"source_rank":0,"column":"","sentiment":"0","news_top_title":null,"news_tag":"","news_rank":0,"length":0,"strategy_id":0,"source":null,"symbols":["CLBK","AMAT","DKUP","PRI","SPG","TENX","LRCX","TEK","WBTN","ORKA","CLS","ETSY","RGA","SHOC","VRTX","EQH","CEVA","MET","LIF","MKTX","SION","DKNG","EBAY","KLAC","THNR","VNQ","ACH","EPAI","BBIO","NABL","AIOT","EXPE","RCKT","SYRE","HEAL","MO","RPD","PRU","SCHH","AFG","DASH","AFL","PBE","HIMS","IETC","LYFT","SKWD","ROOT","PUBM","INTU"],"isVideo":false,"video":null,"gpt_icon":0},{"id":"1150250995","title":"Spyre Therapeutics推出Spy772项目，启动化脓性汗腺炎SkyLight二期临床试验","url":"https://stock-news.laohu8.com/highlight/detail?id=1150250995","media":"美股速递","labels":[],"top":-1,"itemType":null,"share":"https://ttm.financial/m/news/1150250995?lang=zh_cn&edition=fundamental","pubTime":"2026-08-10 20:01","pubTimestamp":1786363318,"startTime":"0","endTime":"0","summary":"Spyre Therapeutics（股票代码：SYRE）正式宣布，其全新研发项目Spy772已启动，并同步开启针对化脓性汗腺炎（Hidradenitis Suppurativa）的SkyLight二期临床试验。这一消息标志着公司在炎症性疾病治疗领域迈出关键一步。","market":"us","thumbnail":"","type":0,"news_type":0,"thumbnails":[],"rights":null,"property":[],"language":"zh","translate_title":"","themeId":null,"theme_name":"","theme_type":"","isJumpTheme":false,"source_url":"","is_publish_highlight":false,"source_rank":0,"column":"","sentiment":"1","news_top_title":null,"news_tag":"","news_rank":0,"length":0,"strategy_id":0,"source":null,"symbols":["BK4139","LFSC","SYRE"],"isVideo":false,"video":null,"gpt_icon":0},{"id":"1177727349","title":"异动解读｜Spyre Therapeutics盘中上涨11.41%，报104.42美元","url":"https://stock-news.laohu8.com/highlight/detail?id=1177727349","media":"行情直击","labels":[],"top":-1,"itemType":null,"share":"https://ttm.financial/m/news/1177727349?lang=zh_cn&edition=fundamental","pubTime":"2026-07-15 00:01","pubTimestamp":1784044892,"startTime":"0","endTime":"0","summary":"7月15日，Spyre Therapeutics盘中上涨11.41%，报104.42美元/股，成交额7429.81万美元。Spyre Therapeutics所在的生物科技行业中，个股表现分化，其中Nextcure Inc.涨213.3%，渤健公司跌8.42%，艾伯维公司跌1.24%，Shuttle Pharmaceuticals Inc涨31.42%，吉利德科学跌0.49%。Spyre Therapeutics是一家临床阶段生物技术公司，致力于通过结合同类最佳的抗体工程、合理的治疗组合以及精准医疗方法，开发下一代炎症性肠病产品，管线涵盖针对α4β7、TL1A和IL-23的延长半衰期抗体。","market":"us","thumbnail":"","type":0,"news_type":0,"thumbnails":[],"rights":null,"property":[],"language":"zh","translate_title":"","themeId":null,"theme_name":"","theme_type":"","isJumpTheme":false,"source_url":"","is_publish_highlight":false,"source_rank":0,"column":"","sentiment":"1","news_top_title":null,"news_tag":"","news_rank":0,"length":0,"strategy_id":0,"source":null,"symbols":["SYRE"],"isVideo":false,"video":null,"gpt_icon":0},{"id":"1193512223","title":"异动解读｜Spyre Therapeutics盘中上涨5.02%，报93.505美元","url":"https://stock-news.laohu8.com/highlight/detail?id=1193512223","media":"行情直击","labels":[],"top":-1,"itemType":null,"share":"https://ttm.financial/m/news/1193512223?lang=zh_cn&edition=fundamental","pubTime":"2026-07-08 00:15","pubTimestamp":1783440956,"startTime":"0","endTime":"0","summary":"7月8日，Spyre Therapeutics盘中上涨5.02%，报93.505美元/股，成交额3902.22万美元。Spyre Therapeutics所在的生物科技行业中，个股中，福泰制药跌1.11%，艾伯维公司涨0.99%，吉利德科学涨3.70%，Moderna跌3.34%，安进涨0.46%。Spyre Therapeutics是一家临床阶段生物技术公司，旨在通过结合同类最佳的抗体工程、合理的治疗组合以及精准医疗方法，创造下一代炎症性肠病产品，产品线包括针对α4β7、TL1A和IL-23的延长半衰期抗体。","market":"hk","thumbnail":"","type":0,"news_type":0,"thumbnails":[],"rights":null,"property":[],"language":"zh","translate_title":"","themeId":null,"theme_name":"","theme_type":"","isJumpTheme":false,"source_url":"","is_publish_highlight":false,"source_rank":0,"column":"","sentiment":"1","news_top_title":null,"news_tag":"","news_rank":0,"length":0,"strategy_id":0,"source":null,"symbols":["SYRE"],"isVideo":false,"video":null,"gpt_icon":0},{"id":"1121929272","title":"异动解读｜SPYRE THERAPEUTICS盘前下跌5.04%，董事减持持续施压股价","url":"https://stock-news.laohu8.com/highlight/detail?id=1121929272","media":"行情直击","labels":[],"top":-1,"itemType":null,"share":"https://ttm.financial/m/news/1121929272?lang=zh_cn&edition=fundamental","pubTime":"2026-06-25 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Therapeutics盘中下跌14.76%，董事减持引发市场关注","url":"https://stock-news.laohu8.com/highlight/detail?id=1143725534","media":"行情直击","labels":["shareholding"],"top":-1,"itemType":null,"share":"https://ttm.financial/m/news/1143725534?lang=zh_cn&edition=fundamental","pubTime":"2026-06-24 21:38","pubTimestamp":1782308280,"startTime":"0","endTime":"0","summary":"6月24日，Spyre Therapeutics盘中下跌14.76%，报85.19美元/股，成交额3673.81万美元。消息面上，公司于6月23日披露内部交易情况，董事HENDERSON MICHAEL THOMAS于6月22日卖出2万股公司股票。对于一家尚处于亏损阶段、市盈率为负的临床期生物技术公司而言，高管减持信号容易放大市场对公司前景的疑虑。Spyre Therapeutics是一家专注于炎症性肠病的生物技术公司，产品线包括针对α4β7、TL1A和IL-23的延长半衰期抗体，当前市净率约12.39倍，总市值约83亿美元。","market":"us","thumbnail":"","type":0,"news_type":0,"thumbnails":[],"rights":null,"property":[],"language":"zh","translate_title":"","themeId":null,"theme_name":"","theme_type":"","isJumpTheme":false,"source_url":"","is_publish_highlight":false,"source_rank":0,"column":"","sentiment":"-1","news_top_title":null,"news_tag":"shareholding","news_rank":0,"length":0,"strategy_id":0,"source":null,"symbols":["SYRE"],"isVideo":false,"video":null,"gpt_icon":0},{"id":"1134617087","title":"异动解读｜SPYRE THERAPEUTICS盘前下跌10.83%，报86.54美元","url":"https://stock-news.laohu8.com/highlight/detail?id=1134617087","media":"行情直击","labels":[],"top":-1,"itemType":null,"share":"https://ttm.financial/m/news/1134617087?lang=zh_cn&edition=fundamental","pubTime":"2026-06-24 16:02","pubTimestamp":1782288144,"startTime":"0","endTime":"0","summary":"6月24日，SPYRE THERAPEUTICS盘前下跌10.83%，报86.54美元/股，成交额1.75万美元。SPYRE 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Therapeutics跌0.14%，吉利德科学涨0.32%，再生元制药公司跌0.01%，安进跌0.58%。其产品线包括针对α4β7、TL1A和IL-23的延长半衰期抗体。（以上内容均基于市场公开消息，由程序或算法智能生成，仅作为股价异动提醒，不作为投资建议或交易依据。","market":"hk","thumbnail":"","type":0,"news_type":0,"thumbnails":[],"rights":null,"property":[],"language":"zh","translate_title":"","themeId":null,"theme_name":"","theme_type":"","isJumpTheme":false,"source_url":"","is_publish_highlight":false,"source_rank":0,"column":"","sentiment":"1","news_top_title":null,"news_tag":"","news_rank":0,"length":0,"strategy_id":0,"source":null,"symbols":["SYRE"],"isVideo":false,"video":null,"gpt_icon":0},{"id":"2643203701","title":"Spyre称，其肠道疾病药物在中期试验中显示出减轻炎症的效果","url":"https://stock-news.laohu8.com/highlight/detail?id=2643203701","media":"路透中文","labels":["dataReport"],"top":-1,"itemType":null,"share":"https://ttm.financial/m/news/2643203701?lang=zh_cn&edition=fundamental","pubTime":"2026-06-15 20:26","pubTimestamp":1781526419,"startTime":"0","endTime":"0","summary":"Spyre称，其肠道疾病药物在中期试验中显示出减轻炎症的效果路透6月15日 - Spyre Therapeutics周一表示，其一款用于治疗肠道疾病的试验性药物在中期临床试验中达到了主要目标，即显著降低了疾病严重程度。次要结果显示，33%的患者达到了临床缓解，而42%的患者在内镜检查中显示出改善，这意味着通过内窥镜检查时，结肠的炎症看起来减轻了。Spyre补充道，SPY002耐受性良好，其安全性特征与其他针对TL1A的药物一致。","market":"us","thumbnail":null,"type":0,"news_type":0,"thumbnails":[],"rights":null,"property":[],"language":"zh","translate_title":"","themeId":null,"theme_name":"","theme_type":"","isJumpTheme":false,"source_url":"https://api.refinitiv.com/data/news/v1/stories/urn:newsml:reuters.com:20260615:nL4T42N14D:1","is_publish_highlight":false,"source_rank":0,"column":"","sentiment":"1","news_top_title":null,"news_tag":"dataReport","news_rank":0,"length":0,"strategy_id":0,"source":null,"symbols":["SYRE","BK4139"],"isVideo":false,"video":null,"gpt_icon":0},{"id":"1132100150","title":"Spyre Therapeutics：二十名受试者出现治疗引发不良事件；两例严重，均与药物无关","url":"https://stock-news.laohu8.com/highlight/detail?id=1132100150","media":"美股速递","labels":[],"top":-1,"itemType":null,"share":"https://ttm.financial/m/news/1132100150?lang=zh_cn&edition=fundamental","pubTime":"2026-06-15 20:03","pubTimestamp":1781525007,"startTime":"0","endTime":"0","summary":"Spyre Therapeutics公布了一项临床试验的更新数据，显示有二十名受试者出现了治疗引发的不良事件。其中，两例被评估为严重级别，但经过分析，这些严重事件均被判定与试验药物本身无关。","market":"us","thumbnail":"","type":0,"news_type":0,"thumbnails":[],"rights":null,"property":[],"language":"zh","translate_title":"","themeId":null,"theme_name":"","theme_type":"","isJumpTheme":false,"source_url":"","is_publish_highlight":false,"source_rank":0,"column":"","sentiment":"-1","news_top_title":null,"news_tag":"","news_rank":0,"length":0,"strategy_id":0,"source":null,"symbols":["SYRE","BK4139"],"isVideo":false,"video":null,"gpt_icon":0},{"id":"1107639416","title":"SPYRE THERAPEUTICS：Spy002在第12周实现33%临床缓解与42%内镜改善","url":"https://stock-news.laohu8.com/highlight/detail?id=1107639416","media":"美股速递","labels":["dataReport"],"top":-1,"itemType":null,"share":"https://ttm.financial/m/news/1107639416?lang=zh_cn&edition=fundamental","pubTime":"2026-06-15 20:02","pubTimestamp":1781524958,"startTime":"0","endTime":"0","summary":"SPYRE THERAPEUTICS公司宣布，其候选药物Spy002在治疗第12周时取得了令人鼓舞的临床数据。\n结果显示，接受治疗的患者中有33%达到了临床缓解的标准。同时，内镜检查评估显示，42%的患者实现了内镜下病情的显著改善。\n这些中期数据为该药物的后续开发提供了积极信号。","market":"us","thumbnail":"","type":0,"news_type":0,"thumbnails":[],"rights":null,"property":[],"language":"zh","translate_title":"","themeId":null,"theme_name":"","theme_type":"","isJumpTheme":false,"source_url":"","is_publish_highlight":false,"source_rank":0,"column":"","sentiment":"1","news_top_title":null,"news_tag":"dataReport","news_rank":0,"length":0,"strategy_id":0,"source":null,"symbols":["BK4139","SYRE"],"isVideo":false,"video":null,"gpt_icon":0},{"id":"1178318875","title":"Spyre公布其潜在同类最佳药物Spy002（抗TL1A）在Skyline试验中治疗中重度溃疡性结肠炎患者的A部分诱导结果","url":"https://stock-news.laohu8.com/highlight/detail?id=1178318875","media":"美股速递","labels":["productRelease"],"top":-1,"itemType":null,"share":"https://ttm.financial/m/news/1178318875?lang=zh_cn&edition=fundamental","pubTime":"2026-06-15 20:01","pubTimestamp":1781524915,"startTime":"0","endTime":"0","summary":"Spyre Therapeutics公司宣布，其候选药物Spy002（一种抗TL1A疗法）在针对中重度溃疡性结肠炎患者的Skyline试验中，取得了A部分的诱导期结果。数据显示，该药物展现出成为同类最佳疗法的潜力。","market":"us","thumbnail":"","type":0,"news_type":0,"thumbnails":[],"rights":null,"property":[],"language":"zh","translate_title":"","themeId":null,"theme_name":"","theme_type":"","isJumpTheme":false,"source_url":"","is_publish_highlight":false,"source_rank":0,"column":"","sentiment":"1","news_top_title":null,"news_tag":"productRelease","news_rank":0,"length":0,"strategy_id":0,"source":null,"symbols":["BK4139","SYRE"],"isVideo":false,"video":null,"gpt_icon":0}],"pageSize":20,"totalPage":3,"pageCount":1,"totalSize":42,"code":"91000000","status":"200"}]}}