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美股
詳情
本頁面由Tiger Trade Technology Pte. Ltd.提供服務
Prime Medicine, Inc.
3.34
+0.0700
2.14%
盤前：
3.39
0.0500
+1.50%
05:09 EST
成交量：
260.77萬
成交額：
866.58萬
市值：
6.03億
市盈率：
-2.32
高：
3.40
開：
3.27
低：
3.17
收：
3.27
52周最高：
6.94
52周最低：
1.11
股本：
1.81億
流通股本：
9,979.87萬
量比：
1.80
換手率：
2.61%
股息：
- -
股息率：
- -
每股收益(TTM):
-1.4387
每股收益(LYR):
-1.6516
淨資產收益率：
-112.34%
總資產收益率：
-35.52%
市淨率：
3.73
市盈率(LYR):
-2.02
資料載入中...
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公司
新聞資訊
公告
Prime Medicine, Inc.盤中異動 快速拉升5.41%報3.90美元
市场透视
·
01/07
Prime Medicine宣佈《新英格蘭醫學雜誌》發表Pm359慢性肉芽腫病臨床數據
美股速递
·
2025/12/07
Prime Medicine, Inc.盤中異動 臨近午盤股價大跌5.00%
市场透视
·
2025/12/03
Prime Medicine：銷售協議招股説明書涵蓋不時發行、銷售最多2億美元普通股的事項
美股速递
·
2025/11/07
Prime Medicine, Inc.盤中異動 快速下挫5.06%報4.69美元
市场透视
·
2025/11/03
新聞稿：Prime Medicine任命Matthew Hawryluk博士為首席商務官
投资观察
·
2025/11/03
Prime Medicine, Inc.盤中異動 早盤大幅下跌5.19%
市场透视
·
2025/10/29
Prime Medicine, Inc.盤中異動 快速拉升5.18%報6.30美元
市场透视
·
2025/10/15
Prime Medicine, Inc.盤中異動 急速拉升5.08%
市场透视
·
2025/10/01
Prime Medicine, Inc.盤中異動 大幅下跌5.02%報3.60美元
市场透视
·
2025/08/11
Prime Medicine, Inc.盤中異動 大幅下挫5.03%報4.15美元
市场透视
·
2025/08/06
Prime Medicine, Inc.盤中異動 急速上漲9.03%
市场透视
·
2025/08/04
Prime Medicine, Inc.盤中異動 股價大跌7.02%
市场透视
·
2025/07/31
BUZZ--美國股票走勢-Biogen、Carvana、Cigna
路透中文
·
2025/07/31
BUZZ-首諾醫藥因股票發行上市而下跌
路透中文
·
2025/07/31
Prime Medicine, Inc.盤中異動 早盤股價大跌5.01%報3.89美元
市场透视
·
2025/07/29
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.wx-sou","directOrigin":true},"property":[],"language":"zh","translate_title":"","themeId":null,"theme_name":"","theme_type":"","isJumpTheme":false,"source_url":"http://gu.qq.com/resources/shy/news/detail-v2/index.html#/?id=nesSN20251203004927a4c87c49&s=b","is_publish_highlight":false,"source_rank":0,"column":"","sentiment":"-1","news_top_title":null,"news_tag":"","news_rank":0,"length":0,"strategy_id":0,"source":"tencent","symbols":["PRME","BK4139"],"gpt_icon":0},{"id":"1121243328","title":"Prime Medicine：銷售協議招股説明書涵蓋不時發行、銷售最多2億美元普通股的事項","url":"https://stock-news.laohu8.com/highlight/detail?id=1121243328","media":"美股速递","labels":[],"top":-1,"itemType":null,"share":"https://ttm.financial/m/news/1121243328?lang=zh_tw&edition=fundamental","pubTime":"2025-11-07 21:08","pubTimestamp":1762520898,"startTime":"0","endTime":"0","summary":"Prime Medicine：销售协议招股说明书涵盖不时发行、销售最多2亿美元普通股的事项","market":"us","thumbnail":"","type":0,"news_type":0,"thumbnails":[],"rights":null,"property":[],"language":"zh","translate_title":"","themeId":"","theme_name":"","theme_type":"","isJumpTheme":false,"source_url":"","is_publish_highlight":false,"source_rank":0,"column":"","sentiment":"0","news_top_title":null,"news_tag":"","news_rank":0,"length":0,"strategy_id":0,"source":null,"symbols":["BK4139","PRME"],"gpt_icon":0},{"id":"2580246445","title":"Prime Medicine, Inc.盤中異動 快速下挫5.06%報4.69美元","url":"https://stock-news.laohu8.com/highlight/detail?id=2580246445","media":"市场透视","labels":[],"top":-1,"itemType":null,"share":"https://ttm.financial/m/news/2580246445?lang=zh_tw&edition=fundamental","pubTime":"2025-11-03 23:04","pubTimestamp":1762182296,"startTime":"0","endTime":"0","summary":"北京时间2025年11月03日23时04分，Prime Medicine, Inc.股票出现波动，股价大幅下挫5.06%。Prime Medicine, Inc.股票所在的生物技术行业中，整体跌幅为0.74%。Prime Medicine, Inc.公司简介：Prime Medicine Inc 是一家生物技术公司，致力于通过部署基因编辑技术 Prime Editing 提供基因疗法来治疗疾病。Prime Editing技术是一种可以通过搜索和替换来恢复基因组中正常遗传功能，可以治疗具有高度未满足医疗需求的广泛疾病和高效广泛的基因编辑技术的下一代技术。","market":"us","thumbnail":null,"type":0,"news_type":0,"thumbnails":[],"rights":{"source":"tencent","url":"http://gu.qq.com/resources/shy/news/detail-v2/index.html#/?id=nesSN20251103230456a48573d3&s=b","rn_cache_url":null,"customStyle":"body{padding-top:10px;}#news_title{font-weight:bold;#titleStyle#;}#news_description span{font-size:12px;#descriptionStyle#;}.footer-note{#statement#}","selectors":".mod-LoadTzbdNews, body","filters":".relate-stock, .hot-list, .recom-box, .wx-sou","directOrigin":true},"property":[],"language":"zh","translate_title":"","themeId":null,"theme_name":"","theme_type":"","isJumpTheme":false,"source_url":"http://gu.qq.com/resources/shy/news/detail-v2/index.html#/?id=nesSN20251103230456a48573d3&s=b","is_publish_highlight":false,"source_rank":0,"column":"","sentiment":"-1","news_top_title":null,"news_tag":"","news_rank":0,"length":0,"strategy_id":0,"source":"tencent","symbols":["PRME","BK4139"],"gpt_icon":0},{"id":"1126222337","title":"新聞稿：Prime Medicine任命Matthew Hawryluk博士為首席商務官","url":"https://stock-news.laohu8.com/highlight/detail?id=1126222337","media":"投资观察","labels":["executive"],"top":-1,"itemType":null,"share":"https://ttm.financial/m/news/1126222337?lang=zh_tw&edition=fundamental","pubTime":"2025-11-03 21:03","pubTimestamp":1762175015,"startTime":"0","endTime":"0","summary":"马萨诸塞州剑桥，2025年11月3日-- Prime Medicine, Inc.是一家致力于提供新一类差异化的一次性治愈性基因疗法的生物技术公司，今天宣布任命Matthew Hawryluk博士为首席商务官。“我们非常高兴欢迎Matt加入我们的领导团队，” Prime Medicine的首席执行官Allan Reine博士表示。“在这样一个令人激动和关键的时刻加入Prime Medicine，我深感荣幸，”Prime Medicine的首席商务官Matthew Hawryluk博士表示。Prime Medicine明确否认任何基于适用法律的义务去更新任何前瞻性声明。","market":"us","thumbnail":"","type":0,"news_type":0,"thumbnails":[],"rights":null,"property":[],"language":"zh","translate_title":"","themeId":"","theme_name":"","theme_type":"","isJumpTheme":false,"source_url":"","is_publish_highlight":false,"source_rank":0,"column":"","sentiment":"1","news_top_title":null,"news_tag":"executive","news_rank":0,"length":0,"strategy_id":0,"source":null,"symbols":["PRME","BK4139"],"gpt_icon":0},{"id":"2579151000","title":"Prime Medicine, Inc.盤中異動 早盤大幅下跌5.19%","url":"https://stock-news.laohu8.com/highlight/detail?id=2579151000","media":"市场透视","labels":[],"top":-1,"itemType":null,"share":"https://ttm.financial/m/news/2579151000?lang=zh_tw&edition=fundamental","pubTime":"2025-10-29 21:38","pubTimestamp":1761745093,"startTime":"0","endTime":"0","summary":"北京时间2025年10月29日21时38分，Prime Medicine, Inc.股票出现波动，股价快速下挫5.19%。Prime Medicine, Inc.股票所在的生物技术行业中，整体跌幅为0.54%。Prime Medicine, Inc.公司简介：Prime Medicine Inc 是一家生物技术公司，致力于通过部署基因编辑技术 Prime Editing 提供基因疗法来治疗疾病。Prime Editing技术是一种可以通过搜索和替换来恢复基因组中正常遗传功能，可以治疗具有高度未满足医疗需求的广泛疾病和高效广泛的基因编辑技术的下一代技术。","market":"us","thumbnail":null,"type":0,"news_type":0,"thumbnails":[],"rights":{"source":"tencent","url":"http://gu.qq.com/resources/shy/news/detail-v2/index.html#/?id=nesSN20251029213813a6d4fa2b&s=b","rn_cache_url":null,"customStyle":"body{padding-top:10px;}#news_title{font-weight:bold;#titleStyle#;}#news_description span{font-size:12px;#descriptionStyle#;}.footer-note{#statement#}","selectors":".mod-LoadTzbdNews, body","filters":".relate-stock, .hot-list, .recom-box, .wx-sou","directOrigin":true},"property":[],"language":"zh","translate_title":"","themeId":null,"theme_name":"","theme_type":"","isJumpTheme":false,"source_url":"http://gu.qq.com/resources/shy/news/detail-v2/index.html#/?id=nesSN20251029213813a6d4fa2b&s=b","is_publish_highlight":false,"source_rank":0,"column":"","sentiment":"0","news_top_title":null,"news_tag":"","news_rank":0,"length":0,"strategy_id":0,"source":"tencent","symbols":["PRME","BK4139"],"gpt_icon":0},{"id":"2575794853","title":"Prime Medicine, Inc.盤中異動 快速拉升5.18%報6.30美元","url":"https://stock-news.laohu8.com/highlight/detail?id=2575794853","media":"市场透视","labels":[],"top":-1,"itemType":null,"share":"https://ttm.financial/m/news/2575794853?lang=zh_tw&edition=fundamental","pubTime":"2025-10-15 21:43","pubTimestamp":1760535803,"startTime":"0","endTime":"0","summary":"北京时间2025年10月15日21时43分，Prime Medicine, Inc.股票出现异动，股价大幅拉升5.18%。Prime Medicine, Inc.股票所在的生物技术行业中，整体跌幅为0.01%。Prime Medicine, Inc.公司简介：Prime Medicine Inc 是一家生物技术公司，致力于通过部署基因编辑技术 Prime Editing 提供基因疗法来治疗疾病。Prime Editing技术是一种可以通过搜索和替换来恢复基因组中正常遗传功能，可以治疗具有高度未满足医疗需求的广泛疾病和高效广泛的基因编辑技术的下一代技术。","market":"us","thumbnail":null,"type":0,"news_type":0,"thumbnails":[],"rights":{"source":"tencent","url":"http://gu.qq.com/resources/shy/news/detail-v2/index.html#/?id=nesSN20251015214324a4618485&s=b","rn_cache_url":null,"customStyle":"body{padding-top:10px;}#news_title{font-weight:bold;#titleStyle#;}#news_description span{font-size:12px;#descriptionStyle#;}.footer-note{#statement#}","selectors":".mod-LoadTzbdNews, body","filters":".relate-stock, .hot-list, .recom-box, .wx-sou","directOrigin":true},"property":[],"language":"zh","translate_title":"","themeId":null,"theme_name":"","theme_type":"","isJumpTheme":false,"source_url":"http://gu.qq.com/resources/shy/news/detail-v2/index.html#/?id=nesSN20251015214324a4618485&s=b","is_publish_highlight":false,"source_rank":0,"column":"","sentiment":"1","news_top_title":null,"news_tag":"","news_rank":0,"length":0,"strategy_id":0,"source":"tencent","symbols":["PRME","BK4139"],"gpt_icon":0},{"id":"2572306891","title":"Prime Medicine, Inc.盤中異動 急速拉升5.08%","url":"https://stock-news.laohu8.com/highlight/detail?id=2572306891","media":"市场透视","labels":[],"top":-1,"itemType":null,"share":"https://ttm.financial/m/news/2572306891?lang=zh_tw&edition=fundamental","pubTime":"2025-10-01 03:43","pubTimestamp":1759261422,"startTime":"0","endTime":"0","summary":"北京时间2025年10月01日03时43分，Prime Medicine, Inc.股票出现异动，股价快速上涨5.08%。Prime Medicine, Inc.股票所在的生物技术行业中，整体涨幅为1.05%。Prime Medicine, Inc.公司简介：Prime Medicine Inc 是一家生物技术公司，致力于通过部署基因编辑技术 Prime Editing 提供基因疗法来治疗疾病。Prime Editing技术是一种可以通过搜索和替换来恢复基因组中正常遗传功能，可以治疗具有高度未满足医疗需求的广泛疾病和高效广泛的基因编辑技术的下一代技术。","market":"us","thumbnail":null,"type":0,"news_type":0,"thumbnails":[],"rights":{"source":"tencent","url":"http://gu.qq.com/resources/shy/news/detail-v2/index.html#/?id=nesSN20251001034342a44f145d&s=b","rn_cache_url":null,"customStyle":"body{padding-top:10px;}#news_title{font-weight:bold;#titleStyle#;}#news_description span{font-size:12px;#descriptionStyle#;}.footer-note{#statement#}","selectors":".mod-LoadTzbdNews, body","filters":".relate-stock, .hot-list, .recom-box, .wx-sou","directOrigin":true},"property":[],"language":"zh","translate_title":"","themeId":null,"theme_name":"","theme_type":"","isJumpTheme":false,"source_url":"http://gu.qq.com/resources/shy/news/detail-v2/index.html#/?id=nesSN20251001034342a44f145d&s=b","is_publish_highlight":false,"source_rank":0,"column":"","sentiment":"1","news_top_title":null,"news_tag":"","news_rank":0,"length":0,"strategy_id":0,"source":"tencent","symbols":["PRME","BK4139"],"gpt_icon":0},{"id":"2558614796","title":"Prime Medicine, Inc.盤中異動 大幅下跌5.02%報3.60美元","url":"https://stock-news.laohu8.com/highlight/detail?id=2558614796","media":"市场透视","labels":[],"top":-1,"itemType":null,"share":"https://ttm.financial/m/news/2558614796?lang=zh_tw&edition=fundamental","pubTime":"2025-08-11 23:53","pubTimestamp":1754927616,"startTime":"0","endTime":"0","summary":"北京时间2025年08月11日23时53分，Prime Medicine, Inc.股票出现波动，股价快速下跌5.02%。Prime Medicine, Inc.股票所在的生物技术行业中，整体涨幅为0.25%。Prime Medicine, Inc.公司简介：Prime Medicine Inc 是一家生物技术公司，致力于通过部署基因编辑技术 Prime Editing 提供基因疗法来治疗疾病。Prime Editing技术是一种可以通过搜索和替换来恢复基因组中正常遗传功能，可以治疗具有高度未满足医疗需求的广泛疾病和高效广泛的基因编辑技术的下一代技术。","market":"us","thumbnail":null,"type":0,"news_type":0,"thumbnails":[],"rights":{"source":"tencent","url":"http://gu.qq.com/resources/shy/news/detail-v2/index.html#/?id=nesSN2025081123533694dcf522&s=b","rn_cache_url":null,"customStyle":"body{padding-top:10px;}#news_title{font-weight:bold;#titleStyle#;}#news_description span{font-size:12px;#descriptionStyle#;}.footer-note{#statement#}","selectors":".mod-LoadTzbdNews, body","filters":".relate-stock, .hot-list, .recom-box, .wx-sou","directOrigin":true},"property":[],"language":"zh","translate_title":"","themeId":null,"theme_name":"","theme_type":"","isJumpTheme":false,"source_url":"http://gu.qq.com/resources/shy/news/detail-v2/index.html#/?id=nesSN2025081123533694dcf522&s=b","is_publish_highlight":false,"source_rank":0,"column":"","sentiment":"-1","news_top_title":null,"news_tag":"","news_rank":0,"length":0,"strategy_id":0,"source":"tencent","symbols":["BK4139","PRME"],"gpt_icon":0},{"id":"2557530369","title":"Prime Medicine, Inc.盤中異動 大幅下挫5.03%報4.15美元","url":"https://stock-news.laohu8.com/highlight/detail?id=2557530369","media":"市场透视","labels":[],"top":-1,"itemType":null,"share":"https://ttm.financial/m/news/2557530369?lang=zh_tw&edition=fundamental","pubTime":"2025-08-06 22:25","pubTimestamp":1754490328,"startTime":"0","endTime":"0","summary":"北京时间2025年08月06日22时25分，Prime Medicine, Inc.股票出现异动，股价大幅跳水5.03%。Prime Medicine, Inc.股票所在的生物技术行业中，整体跌幅为0.45%。Prime Medicine, Inc.公司简介：Prime Medicine Inc 是一家生物技术公司，致力于通过部署基因编辑技术 Prime Editing 提供基因疗法来治疗疾病。Prime Editing技术是一种可以通过搜索和替换来恢复基因组中正常遗传功能，可以治疗具有高度未满足医疗需求的广泛疾病和高效广泛的基因编辑技术的下一代技术。","market":"us","thumbnail":null,"type":0,"news_type":0,"thumbnails":[],"rights":{"source":"tencent","url":"http://gu.qq.com/resources/shy/news/detail-v2/index.html#/?id=nesSN20250806222529a6d6caba&s=b","rn_cache_url":null,"customStyle":"body{padding-top:10px;}#news_title{font-weight:bold;#titleStyle#;}#news_description span{font-size:12px;#descriptionStyle#;}.footer-note{#statement#}","selectors":".mod-LoadTzbdNews, body","filters":".relate-stock, .hot-list, .recom-box, .wx-sou","directOrigin":true},"property":[],"language":"zh","translate_title":"","themeId":null,"theme_name":"","theme_type":"","isJumpTheme":false,"source_url":"http://gu.qq.com/resources/shy/news/detail-v2/index.html#/?id=nesSN20250806222529a6d6caba&s=b","is_publish_highlight":false,"source_rank":0,"column":"","sentiment":"-1","news_top_title":null,"news_tag":"","news_rank":0,"length":0,"strategy_id":0,"source":"tencent","symbols":["PRME","BK4139"],"gpt_icon":0},{"id":"2556822583","title":"Prime Medicine, Inc.盤中異動 急速上漲9.03%","url":"https://stock-news.laohu8.com/highlight/detail?id=2556822583","media":"市场透视","labels":[],"top":-1,"itemType":null,"share":"https://ttm.financial/m/news/2556822583?lang=zh_tw&edition=fundamental","pubTime":"2025-08-04 21:32","pubTimestamp":1754314323,"startTime":"0","endTime":"0","summary":"北京时间2025年08月04日21时32分，Prime Medicine, Inc.股票出现异动，股价大幅上涨9.03%。Prime Medicine, Inc.股票所在的生物技术行业中，整体涨幅为0.60%。Prime Medicine, Inc.公司简介：Prime Medicine Inc 是一家生物技术公司，致力于通过部署基因编辑技术 Prime Editing 提供基因疗法来治疗疾病。Prime Editing技术是一种可以通过搜索和替换来恢复基因组中正常遗传功能，可以治疗具有高度未满足医疗需求的广泛疾病和高效广泛的基因编辑技术的下一代技术。","market":"us","thumbnail":null,"type":0,"news_type":0,"thumbnails":[],"rights":{"source":"tencent","url":"http://gu.qq.com/resources/shy/news/detail-v2/index.html#/?id=nesSN20250804213203a4748f94&s=b","rn_cache_url":null,"customStyle":"body{padding-top:10px;}#news_title{font-weight:bold;#titleStyle#;}#news_description span{font-size:12px;#descriptionStyle#;}.footer-note{#statement#}","selectors":".mod-LoadTzbdNews, body","filters":".relate-stock, .hot-list, .recom-box, 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是一家生物技术公司，致力于通过部署基因编辑技术 Prime Editing 提供基因疗法来治疗疾病。Prime Editing技术是一种可以通过搜索和替换来恢复基因组中正常遗传功能，可以治疗具有高度未满足医疗需求的广泛疾病和高效广泛的基因编辑技术的下一代技术。","market":"us","thumbnail":null,"type":0,"news_type":0,"thumbnails":[],"rights":{"source":"tencent","url":"http://gu.qq.com/resources/shy/news/detail-v2/index.html#/?id=nesSN20250731213143a6cbc9f1&s=b","rn_cache_url":null,"customStyle":"body{padding-top:10px;}#news_title{font-weight:bold;#titleStyle#;}#news_description span{font-size:12px;#descriptionStyle#;}.footer-note{#statement#}","selectors":".mod-LoadTzbdNews, body","filters":".relate-stock, .hot-list, .recom-box, 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(为便利非英文母语者，路透将其报导自动化翻译为数种其他语言。由于自动化翻译可能有误，或未能包含所需语境，路透不保证自动化翻译文本的准确性，仅是为了便利读者而提供自动化翻译。对于因为使用自动化翻译功能而造成的任何损害或损失，路透不承担任何责任。","market":"us","thumbnail":null,"type":0,"news_type":0,"thumbnails":[],"rights":null,"property":[],"language":"zh","translate_title":"","themeId":null,"theme_name":"","theme_type":"","isJumpTheme":false,"source_url":"https://api.refinitiv.com/data/news/v1/stories/urn:newsml:reuters.com:20250731:nL4S3TS1GV:1","is_publish_highlight":false,"source_rank":0,"column":"","sentiment":"0","news_top_title":null,"news_tag":"","news_rank":0,"length":0,"strategy_id":0,"source":null,"symbols":["SGXZ51526630.SGD","NEM","LU0354030511.USD","CI","LU2286300806.USD","LU2491050154.USD","CVNA","LU0738911758.USD","BIIB","LU2491049909.HKD","IE00B19Z9505.USD","LU0079474960.USD","LU1551013425.SGD","LU1334329650.SGD","IE0009G5SDU7.USD","LU2242649171.HKD","BK4608","LU0345774391.USD","LU2461242641.AUD","IE0034235188.USD","LU1934455863.HKD","LU0390134368.USD","LU1720051108.HKD","BK4214","APLD","LU1066051498.USD","LU0498741890.SGD","LU0757359368.USD","LU1366333091.USD","LU1582987324.SGD","SG9999018865.SGD","LU0672654240.SGD","LU0302445910.USD","IE00B894F039.SGD","LU1153585028.USD","LU1914381329.SGD","LU0965509101.SGD","CVS","LU0057025933.USD","MSFT","TFX","BK4576","PRME","LU0187121727.USD","LU2602419157.SGD","LU0323591593.USD","IE00BSNM7G36.USD","LU2089284900.SGD","NCLH","LU0211327993.USD"],"gpt_icon":0},{"id":"2555242600","title":"BUZZ-首諾醫藥因股票發行上市而下跌","url":"https://stock-news.laohu8.com/highlight/detail?id=2555242600","media":"路透中文","labels":["shareholding"],"top":-1,"itemType":null,"share":"https://ttm.financial/m/news/2555242600?lang=zh_tw&edition=fundamental","pubTime":"2025-07-31 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22:33","pubTimestamp":1753799636,"startTime":"0","endTime":"0","summary":"北京时间2025年07月29日22时33分，Prime Medicine, Inc.股票出现异动，股价大幅下挫5.01%。Prime Medicine, Inc.股票所在的生物技术行业中，整体涨幅为0.31%。Prime Medicine, Inc.公司简介：Prime Medicine Inc 是一家生物技术公司，致力于通过部署基因编辑技术 Prime Editing 提供基因疗法来治疗疾病。Prime Editing技术是一种可以通过搜索和替换来恢复基因组中正常遗传功能，可以治疗具有高度未满足医疗需求的广泛疾病和高效广泛的基因编辑技术的下一代技术。","market":"us","thumbnail":null,"type":0,"news_type":0,"thumbnails":[],"rights":{"source":"tencent","url":"http://gu.qq.com/resources/shy/news/detail-v2/index.html#/?id=nesSN20250729223356a6c80ab4&s=b","rn_cache_url":null,"customStyle":"body{padding-top:10px;}#news_title{font-weight:bold;#titleStyle#;}#news_description span{font-size:12px;#descriptionStyle#;}.footer-note{#statement#}","selectors":".mod-LoadTzbdNews, body","filters":".relate-stock, .hot-list, .recom-box, 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