European equities traded in the US as American depositary receipts were heading lower late Tuesday morning, declining 0.54% to 1,914.78 on the S&P Europe Select ADR Index.

From continental Europe, the gainers were led by telecommunications company Nokia (NOK) and petroleum refiner Equinor (EQNR), which rose 2.5% and 2% respectively. They were followed by medical device maker EDAP (FOCL) and oil and gas company Eni (E), which were up 1% and 1.5% respectively.

The decliners from continental Europe were led by accommodations booking site trivago (TRVG) and biopharmaceutical company Cellectis (CLLS), which fell 2.3% and 11% respectively. They were followed by biopharmaceutical company DBV Technologies (DBVT) and biotech firm BioNTech (BNTX), which dropped 3% and 2.6% respectively.

The gainers from the UK were led by biopharmaceutical companies Biodexa Pharmaceuticals (BDRX) and Mereo BioPharma Group (MREO), which advanced 15% and 1.8% respectively. They were followed by oil and gas companies Shell (SHEL) and BP (BP), which increased 1.9% and 2% respectively.

The decliners from the UK and Ireland were led by pharmaceutical company Silence Therapeutics (SLN) and biopharmaceutical company Akari Therapeutics (AKTX), which lost 6.5% and 6.6% respectively. They were followed by biotech firm Trinity Biotech (TRIB) and biopharmaceutical company Bicycle Therapeutics (BCYC), which were down 5.7% and 3.1% respectively.