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Cassava Sciences Inc

1.61

-0.0100-0.62%

Post-market: 1.60-0.0100-0.62%19:57 EDT

Volume:435.09K

Turnover:707.13K

Market Cap:77.78M

PE:-1.10

High:1.67

Open:1.64

Low:1.60

Close:1.62

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Overview Company News Filings

Cassava Sciences Inc. Announces New Clinical Study for Simufilam as Potential Treatment for TSC-Related Epilepsy

Cassava Appoints Angélique Bordey, PhD, to Enhance Preclinical Program in TSC

Cassava Sciences CMO James Kupiec to Retire

MT Newswires Live

Cassava Sciences Chief Medical Officer Kupiec Retires

Cassava Sciences Announces Leadership Changes Amid Strategic Shift

Cassava Sciences chief medical officer James Kupiec to retire

Cassava Announces Retirement of Chief Medical Officer, DR. Jim Kupiec, and Appointment of DR. Jack Moore as Senior Vice President, Clinical Development

THOMSON REUTERS

Press Release: Cassava Announces Retirement of Chief Medical Officer, Dr. Jim Kupiec, and Appointment of Dr. Jack Moore as Senior Vice President, Clinical Development

Down -39.52% in 4 Weeks, Here's Why Cassava Sciences (SAVA) Looks Ripe for a Turnaround

Is the Future Bleak for SAVA Stock Following Another Setback?

Cassava Sciences must face malicious prosecution lawsuit over Alzheimer's drug

SAVA Stock Down as Alzheimer's Drug Fails in Second Late-Stage Study

Equity Markets Close Higher, Weak Consumer Confidence Data Lifts Fed Easing Hopes

MT Newswires Live

Top Midday Decliners

MT Newswires Live

Cassava Sciences Price Target Maintained With a $2.00/Share by HC Wainwright & Co.

Cassava Sciences’ Alzheimer’s Drug Trials Fall Short, Neutral Rating Maintained Amid Uncertainties

Cassava Sciences Stock Falls as Alzheimer Drug Misses Targets, To Be Discontinued

Cassava Sciences Shares Drop 21% After Co to Discontinue Development of Alzheimer's Disease Drug

THOMSON REUTERS

BUZZ-Cassava falls after stopping development of Alzheimer's drug

Cassava Sciences' Phase 3 Study of Simufilam Showed No Benefit for Alzheimer's Patients

MT Newswires Live

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Announces New Clinical Study for Simufilam as Potential Treatment for TSC-Related Epilepsy","url":"https://stock-news.laohu8.com/highlight/detail?id=2532075088","media":"Reuters","labels":["executive","dataReport"],"top":-1,"itemType":null,"share":"https://ttm.financial/m/news/2532075088?lang=en_us&edition=fundamental","pubTime":"2025-05-01 19:30","pubTimestamp":1746099035,"startTime":"0","endTime":"0","summary":"Cassava Sciences Inc., a clinical-stage biotechnology company, has announced the appointment of Dr. Angélique Bordey as Senior Vice President, Neuroscience, to enhance its preclinical program in TSC-related epilepsy. Dr. Bordey, who will continue her academic role at Yale School of Medicine, will lead the scientific evaluation of simufilam, a potential novel treatment for this challenging epilepsy syndrome. Her expertise is expected to advance Cassava's research and development efforts, following a recent patent and license agreement with Yale University. This initiative marks a significant step in exploring new treatment options for TSC-related epilepsy.Disclaimer: This news brief was created by Public Technologies  using generative artificial intelligence. While PUBT strives to provide accurate and timely information, this AI-generated content is for informational purposes only and should not be interpreted as financial, investment, or legal advice. Cassava Sciences Inc. published th","market":"us","thumbnail":null,"type":0,"news_type":0,"thumbnails":[],"rights":null,"property":["earning"],"language":"en","translate_title":"","themeId":null,"theme_name":"","theme_type":"","isJumpTheme":false,"source_url":"https://api.refinitiv.com/data/news/v1/stories/urn:newsml:reuters.com:20250501:nNDL4JzSmV:1","is_publish_highlight":false,"source_rank":0,"column":"","sentiment":"1","news_top_title":null,"news_tag":"executive,dataReport","news_rank":0,"length":0,"strategy_id":0,"source":null,"symbols":["SAVA","NDAQ"],"gpt_icon":0},{"id":"2532204079","title":"Cassava Appoints Angélique Bordey, PhD, to Enhance Preclinical Program in TSC","url":"https://stock-news.laohu8.com/highlight/detail?id=2532204079","media":"GlobeNewswire","labels":["executive"],"top":-1,"itemType":null,"share":"https://ttm.financial/m/news/2532204079?lang=en_us&edition=fundamental","pubTime":"2025-05-01 19:30","pubTimestamp":1746099000,"startTime":"0","endTime":"0","summary":"As SVP, Neuroscience, Dr. Bordey will lead Cassava’s ongoing research and development efforts. AUSTIN, Texas, May 01, 2025  -- Cassava Sciences, Inc. , a clinical-stage biotechnology company focused on developing novel, investigational treatments for central nervous system  disorders, today announced that Angélique Bordey, PhD, has joined the Company as Senior Vice President , Neuroscience, while continuing her tenured academic position at Yale School of Medicine on a part time basis.Dr. Bordey is a highly respected, widely published neuroscientist and tenured professor who has dedicated her career to understanding neuronal signaling and unlocking the neurobiology of diseases such as tuberous sclerosis complex. She has been a member of the Departments of Neurosurgery and Cellular and Molecular Physiology at Yale School of Medicine for more than two dec","market":"us","thumbnail":null,"type":0,"news_type":0,"thumbnails":[],"rights":null,"property":[],"language":"en","translate_title":"","themeId":null,"theme_name":"","theme_type":"","isJumpTheme":false,"source_url":"https://finance.yahoo.com/news/cassava-appoints-ang-lique-bordey-113000235.html","is_publish_highlight":false,"source_rank":0,"column":"","sentiment":"0","news_top_title":null,"news_tag":"executive","news_rank":0,"length":0,"strategy_id":0,"source":"yahoofinance","symbols":["BK4135","BK4585","SAVA","SAVAW","BK4547","BK4007","CNS","BK4588"],"gpt_icon":0},{"id":"2529800359","title":"Cassava Sciences CMO James Kupiec to Retire","url":"https://stock-news.laohu8.com/highlight/detail?id=2529800359","media":"MT Newswires Live","labels":["executive"],"top":-1,"itemType":null,"share":"https://ttm.financial/m/news/2529800359?lang=en_us&edition=fundamental","pubTime":"2025-04-22 05:45","pubTimestamp":1745271900,"startTime":"0","endTime":"0","summary":"Cassava Sciences (SAVA) said Monday that Chief Medical Officer James Kupiec will retire, effective May 9.Shares of Cassava were down 0.7% in after-hours trading.","market":"us","thumbnail":null,"type":0,"news_type":0,"thumbnails":[],"rights":null,"property":[],"language":"en","translate_title":"","themeId":null,"theme_name":"","theme_type":"","isJumpTheme":false,"source_url":"https://www.mtnewswires.com/","is_publish_highlight":false,"source_rank":0,"column":"","sentiment":"-2","news_top_title":null,"news_tag":"executive","news_rank":0,"length":0,"strategy_id":0,"source":"mtnewswires_news","symbols":["BK4547","BK4007","SAVA","BK4585","BK4588"],"gpt_icon":0},{"id":"2529356819","title":"Cassava Sciences Chief Medical Officer Kupiec Retires","url":"https://stock-news.laohu8.com/highlight/detail?id=2529356819","media":"Dow Jones","labels":["executive"],"top":-1,"itemType":null,"share":"https://ttm.financial/m/news/2529356819?lang=en_us&edition=fundamental","pubTime":"2025-04-22 05:17","pubTimestamp":1745270220,"startTime":"0","endTime":"0","summary":"Cassava Sciences said its chief medical officer, Dr. James Kupiec, is retiring, effective May 9.Under Kupiec, the clinical-stage biotechnology company completed a clinical trial program in Alzheimer's disease drug development. Kupiec has been chief medical officer since December 2022 following a stint as Cassava's chief clinical development officer. He previously worked at Pfizer.Cassava on Monday also said it appointed Jack Moore as senior vice president of clinical development. Moore was most recently the head of global medical affairs at Alector, and also worked at Janssen Pharmaceutica, Novartis Pharmaceuticals, and Celgene.","market":"sg","thumbnail":null,"type":0,"news_type":0,"thumbnails":[],"rights":null,"property":[],"language":"en","translate_title":"","themeId":null,"theme_name":"","theme_type":"","isJumpTheme":false,"source_url":"https://dowjonesnews.com/newdjn/logon.aspx?AL=N","is_publish_highlight":false,"source_rank":0,"column":"","sentiment":"-1","news_top_title":null,"news_tag":"executive","news_rank":0,"length":0,"strategy_id":0,"source":null,"symbols":["LU0321505439.SGD","IE00B19Z3581.USD","IE00BBT3K403.USD","BK4547","IE000M9KFDE8.USD","LU0058720904.USD","LU1023059063.AUD","SAVA","IE00B19Z3B42.SGD","SG9999013999.USD","SG9999003800.SGD","LU1894683264.USD","BK4550","LU0289739699.SGD","LU0321505868.SGD","LU0170899867.USD","SG9999002232.USD","BK4581","BK4007","LU0225284248.USD","LU0234572021.USD","BK4592","BK4534","BK4585","LU0225771236.USD","LU0306807586.USD","LU1883839398.USD","IE0002270589.USD","LU0306806265.USD","LU0456855351.SGD","SGXZ57979304.SGD","SG9999001176.USD","LU1057294990.SGD","SG9999002224.SGD","SG9999011175.SGD","IE00BLSP4452.SGD","SG9999001176.SGD","BK4599","LU0122379950.USD","IE00BLSP4239.USD","LU0985481810.HKD","BK4568","LU0868494617.USD","LU1066053197.SGD","LU1894683348.USD","LU1066051498.USD","BK4533","BK4588"],"gpt_icon":1},{"id":"2529021353","title":"Cassava Sciences Announces Leadership Changes Amid Strategic Shift","url":"https://stock-news.laohu8.com/highlight/detail?id=2529021353","media":"TIPRANKS","labels":["executive"],"top":-1,"itemType":null,"share":"https://ttm.financial/m/news/2529021353?lang=en_us&edition=fundamental","pubTime":"2025-04-22 04:56","pubTimestamp":1745268989,"startTime":"0","endTime":"0","summary":"The latest announcement is out from Cassava Sciences ( ($SAVA) ). Cassava Sciences announced the retirement of its Chief Medical Officer, James W. ...","market":"nz","thumbnail":null,"type":0,"news_type":0,"thumbnails":[],"rights":{"source":"tipranks_highlight","url":"https://www.tipranks.com/news/company-announcements/cassava-sciences-announces-leadership-changes-amid-strategic-shift?utm_source=itigerup.com&utm_medium=referral","rn_cache_url":null,"directOrigin":true},"property":[],"language":"en","translate_title":"","themeId":null,"theme_name":"","theme_type":"","isJumpTheme":false,"source_url":"https://www.tipranks.com/news/company-announcements/cassava-sciences-announces-leadership-changes-amid-strategic-shift?utm_source=itigerup.com&utm_medium=referral","is_publish_highlight":false,"source_rank":0,"column":"","sentiment":"0","news_top_title":null,"news_tag":"executive","news_rank":0,"length":0,"strategy_id":0,"source":"tipranks_highlight","symbols":["BK4007","BK4585","SAVA","BK4547","BK4588"],"gpt_icon":0},{"id":"2529358711","title":"Cassava Sciences chief medical officer James Kupiec to retire","url":"https://stock-news.laohu8.com/highlight/detail?id=2529358711","media":"TIPRANKS","labels":["executive"],"top":-1,"itemType":null,"share":"https://ttm.financial/m/news/2529358711?lang=en_us&edition=fundamental","pubTime":"2025-04-22 04:35","pubTimestamp":1745267751,"startTime":"0","endTime":"0","summary":"Cassava Sciences (SAVA) announced the retirement of James Kupiec, chief medical officer, effective May 9. The company also appointed Jack Moore as ...","market":"fut","thumbnail":null,"type":0,"news_type":0,"thumbnails":[],"rights":{"source":"tipranks_highlight","url":"https://www.tipranks.com/news/the-fly/cassava-sciences-chief-medical-officer-james-kupiec-to-retire?utm_source=itigerup.com&utm_medium=referral","rn_cache_url":null,"directOrigin":true},"property":[],"language":"en","translate_title":"","themeId":null,"theme_name":"","theme_type":"","isJumpTheme":false,"source_url":"https://www.tipranks.com/news/the-fly/cassava-sciences-chief-medical-officer-james-kupiec-to-retire?utm_source=itigerup.com&utm_medium=referral","is_publish_highlight":false,"source_rank":0,"column":"","sentiment":"-1","news_top_title":null,"news_tag":"executive","news_rank":0,"length":0,"strategy_id":0,"source":"tipranks_highlight","symbols":["BK4547","BK4588","SAVA","BK4007","BK4585"],"gpt_icon":0},{"id":"2529358524","title":"Cassava Announces Retirement of Chief Medical Officer, DR. Jim Kupiec, and Appointment of DR. Jack Moore as Senior Vice President, Clinical Development","url":"https://stock-news.laohu8.com/highlight/detail?id=2529358524","media":"THOMSON REUTERS","labels":[],"top":-1,"itemType":null,"share":"https://ttm.financial/m/news/2529358524?lang=en_us&edition=fundamental","pubTime":"2025-04-22 04:30","pubTimestamp":1745267400,"startTime":"0","endTime":"0","summary":null,"market":"nz","thumbnail":null,"type":0,"news_type":0,"thumbnails":[],"rights":null,"property":[],"language":"en","translate_title":"","themeId":null,"theme_name":"","theme_type":"","isJumpTheme":false,"source_url":"https://api.refinitiv.com/data/news/v1/stories/urn:newsml:reuters.com:20250421:nTUA9SNLVK:1","is_publish_highlight":false,"source_rank":0,"column":"","sentiment":"0","news_top_title":null,"news_tag":"","news_rank":0,"length":0,"strategy_id":0,"source":"reuters_en_live","symbols":["BK4585","SAVA","BK4007","BK4588","BK4547"],"gpt_icon":0},{"id":"2529035832","title":"Press Release: Cassava Announces Retirement of Chief Medical Officer, Dr. Jim Kupiec, and Appointment of Dr. Jack Moore as Senior Vice President, Clinical Development","url":"https://stock-news.laohu8.com/highlight/detail?id=2529035832","media":"Dow Jones","labels":["executive"],"top":-1,"itemType":null,"share":"https://ttm.financial/m/news/2529035832?lang=en_us&edition=fundamental","pubTime":"2025-04-22 04:30","pubTimestamp":1745267400,"startTime":"0","endTime":"0","summary":"Cassava Announces Retirement of Chief Medical Officer, Dr. Jim Kupiec, and Appointment of Dr. Jack Moore as Senior Vice President, Clinical Development. Dr. Moore joins Cassava as Senior Vice President, Clinical Development, effective April 28, 2025. He will be responsible for advancing the clinical evaluation of simufilam in new potential indications, including TSC. Dr. Moore will build on an established track record of working in leading global pharmaceutical companies to advance novel compounds for the treatment of CNS disorders.Jack Moore is an accomplished biopharmaceutical executive with extensive drug development expertise in CNS and neurodegenerative diseases including Alzheimer's disease, multiple sclerosis, amyotrophic lateral sclerosis, and other neuro-immunologic and oncologic disorders. He has a history of building and executing clinical development strategies and publication plans, as well as engaging with key opinion leaders, advisory boards, patient advocates, and medic","market":"fut","thumbnail":null,"type":0,"news_type":0,"thumbnails":[],"rights":null,"property":[],"language":"en","translate_title":"","themeId":null,"theme_name":"","theme_type":"","isJumpTheme":false,"source_url":"https://dowjonesnews.com/newdjn/logon.aspx?AL=N","is_publish_highlight":false,"source_rank":0,"column":"","sentiment":"0","news_top_title":null,"news_tag":"executive","news_rank":0,"length":0,"strategy_id":0,"source":null,"symbols":["BK4547","BK4007","CNS","BK4135","BK4585","BK4588","SAVA"],"gpt_icon":0},{"id":"2524146146","title":"Down -39.52% in 4 Weeks, Here's Why Cassava Sciences (SAVA) Looks Ripe for a Turnaround","url":"https://stock-news.laohu8.com/highlight/detail?id=2524146146","media":"Zacks","labels":[],"top":-1,"itemType":null,"share":"https://ttm.financial/m/news/2524146146?lang=en_us&edition=fundamental","pubTime":"2025-04-01 21:35","pubTimestamp":1743514507,"startTime":"0","endTime":"0","summary":"A downtrend has been apparent in Cassava Sciences, Inc.  lately with too much selling pressure. The stock has declined 39.5% over the past four weeks. However, given the fact that it is now in oversold territory and Wall Street analysts are majorly in agreement about the company's ability to report better earnings than they predicted earlier, the stock could be due for a turnaround.We use Relative Strength Index , one of the most commonly used technical indicators, for spotting whether a stock is oversold. This is a momentum oscillator that measures the speed and change of price movements.RSI oscillates between zero and 100. Usually, a stock is considered oversold when its RSI reading falls below 30.Technically, every stock oscillates between being overbought and oversold irrespective of the quality of their fundamentals. And the beauty of RSI is that it helps you quickly and easily check if a stock's price is reaching a point of reversal.The RSI reading of 24.25 for SAVA is an indicat","market":"us","thumbnail":null,"type":0,"news_type":0,"thumbnails":[],"rights":null,"property":[],"language":"en","translate_title":"","themeId":null,"theme_name":"","theme_type":"","isJumpTheme":false,"source_url":"https://finance.yahoo.com/news/down-39-52-4-weeks-133507471.html","is_publish_highlight":false,"source_rank":0,"column":"","sentiment":"1","news_top_title":null,"news_tag":"","news_rank":0,"length":0,"strategy_id":0,"source":"yahoofinance","symbols":["SAVA","BK4150","BK4585","RSI","BK4588","BK4547","SAVAW","BK4007"],"gpt_icon":1},{"id":"2524240539","title":"Is the Future Bleak for SAVA Stock Following Another Setback?","url":"https://stock-news.laohu8.com/highlight/detail?id=2524240539","media":"Zacks","labels":[],"top":-1,"itemType":null,"share":"https://ttm.financial/m/news/2524240539?lang=en_us&edition=fundamental","pubTime":"2025-03-31 22:00","pubTimestamp":1743429600,"startTime":"0","endTime":"0","summary":"Cassava Sciences SAVA recently suffered yet another setback, which raises concern regarding its prospects.Last week, the company announced that the phase III study REFOCUS-ALZ on lead pipeline candidate, simufilam, in mild-to-moderate Alzheimer’s disease  failed to achieve the prespecified co-primary endpoints.Treatment with the drug failed to achieve a significant reduction in cognitive and functional decline in AD patients when compared to placebo over 76 weeks, as assessed by the ADAS-COG12 and ADCS-ADL scales. The study also failed to meet any pre-specified secondary and exploratory biomarker endpoint.The REFOCUS-ALZ study enrolled 1,125 AD patients, who were randomized equally to receive either a twice-daily oral dose of simufilam  or placebo for 76 weeks. The candidate, however, demonstrated an acceptable safety profile in the study.However, with only $128.6 million in cash and equivalents at the end of December 2024, it is not certain how far the company can fund its operations.","market":"us","thumbnail":null,"type":0,"news_type":0,"thumbnails":[],"rights":null,"property":[],"language":"en","translate_title":"","themeId":null,"theme_name":"","theme_type":"","isJumpTheme":false,"source_url":"https://finance.yahoo.com/news/future-bleak-sava-stock-following-140000247.html","is_publish_highlight":false,"source_rank":0,"column":"","sentiment":"-1","news_top_title":null,"news_tag":"","news_rank":0,"length":0,"strategy_id":0,"source":"yahoofinance","symbols":["BK4581","LU1720051108.HKD","LU2602419157.SGD","LU0203201768.USD","LU0238689110.USD","LU1983299246.USD","LU2023250504.SGD","LU1712237335.SGD","SAVA","SG9999015978.USD","SAVAW","SG9999018857.SGD","LU0823416689.USD","LU1551013425.SGD","BK4533","LU1988902786.USD","LU2357305700.SGD","LLY","LU2360106947.USD","LU1061106388.HKD","IE00B19Z9Z06.USD","IE0004445239.USD","LU0256863902.USD","LU1917777945.USD","LU1868836591.USD","IE00B1BXHZ80.USD","LU0109391861.USD","LU1232071149.USD","SG9999018865.SGD","BK4588","LU2324357040.USD","IE00B4R5TH58.HKD","LU1551013342.USD","LU1267930730.SGD","LU1069344957.HKD","LU1804176565.USD","LU1093756325.SGD","LU0354030438.USD","LU2461242641.AUD","BK4532","IE00BFTCPJ56.SGD","LU0109394709.USD","LU2552382215.SGD","SGXZ31699556.SGD","SG9999014906.USD","LU2237443382.USD","LU0889565916.HKD","IE0009355771.USD","LU0106261372.USD","IE00BJJMRZ35.SGD","BIIB"],"gpt_icon":1},{"id":"2522376893","title":"Cassava Sciences must face malicious prosecution lawsuit over Alzheimer's drug","url":"https://stock-news.laohu8.com/highlight/detail?id=2522376893","media":"Reuters","labels":[],"top":-1,"itemType":null,"share":"https://ttm.financial/m/news/2522376893?lang=en_us&edition=fundamental","pubTime":"2025-03-27 03:38","pubTimestamp":1743017884,"startTime":"0","endTime":"0","summary":"Cassava Sciences must face malicious prosecution lawsuit over Alzheimer's drugBy Jonathan Stempel NEW YORK, March 26 (Reuters) - The biotechnology company Cassava Sciences SAVA.O failed on Wednesday t","market":"nz","thumbnail":null,"type":0,"news_type":0,"thumbnails":[],"rights":null,"property":[],"language":"en","translate_title":"","themeId":null,"theme_name":"","theme_type":"","isJumpTheme":false,"source_url":"https://api.refinitiv.com/data/news/v1/stories/urn:newsml:reuters.com:20250326:nL2N3Q90Z4:1","is_publish_highlight":false,"source_rank":0,"column":"","sentiment":"-1","news_top_title":null,"news_tag":"","news_rank":0,"length":0,"strategy_id":0,"source":null,"symbols":["BK4585","BK4588","SAVA","BK4547","BK4007"],"gpt_icon":1},{"id":"2522880492","title":"SAVA Stock Down as Alzheimer's Drug Fails in Second Late-Stage Study","url":"https://stock-news.laohu8.com/highlight/detail?id=2522880492","media":"Zacks","labels":[],"top":-1,"itemType":null,"share":"https://ttm.financial/m/news/2522880492?lang=en_us&edition=fundamental","pubTime":"2025-03-26 19:43","pubTimestamp":1742989380,"startTime":"0","endTime":"0","summary":"Shares of Cassava Sciences SAVA plunged 32.1% on Tuesday after the company announced that its lead pipeline candidate, simufilam, failed to meet the prespecified co-primary endpoints in the second late-stage study for Alzheimer’s disease . Simufilam is SAVA’s proprietary, investigational oral small molecule that targets the filamin A protein.Cassava released top-line results from the phase III REFOCUS-ALZ study, which evaluated simufilam in patients with mild-to-moderate AD. Treatment with the drug failed to achieve a significant reduction in cognitive and functional decline in AD patients when compared to placebo over 76 weeks, as assessed by the ADAS-COG12 and ADCS-ADL scales. The study also failed to meet any pre-specified secondary and exploratory biomarker endpoints.The REFOCUS-ALZ study had enrolled 1,125 AD patients who were randomized equally to receive either a twice-daily, oral dose of simufilam  or placebo for 76 weeks. The candidate, however, demonstrated an acceptable 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Markets Close Higher, Weak Consumer Confidence Data Lifts Fed Easing Hopes","url":"https://stock-news.laohu8.com/highlight/detail?id=2522783839","media":"MT Newswires Live","labels":[],"top":-1,"itemType":null,"share":"https://ttm.financial/m/news/2522783839?lang=en_us&edition=fundamental","pubTime":"2025-03-26 04:34","pubTimestamp":1742934842,"startTime":"0","endTime":"0","summary":"US benchmark equity indexes closed higher Tuesday as markets reacted to the latest economic data and comments from a Federal Reserve governor.The Nasdaq Composite rose 0.5% to 18,271.9, while the S&P 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Midday Decliners","url":"https://stock-news.laohu8.com/highlight/detail?id=2522188162","media":"MT Newswires Live","labels":[],"top":-1,"itemType":null,"share":"https://ttm.financial/m/news/2522188162?lang=en_us&edition=fundamental","pubTime":"2025-03-26 02:57","pubTimestamp":1742929058,"startTime":"0","endTime":"0","summary":"Mural Oncology  said Tuesday it will stop the development of nemvaleukin alfa for platinum-resistant ovarian cancer as it believes a phase 3 trial of the drug combined with Merck's  Keytruda is \"highly unlikely to achieve success\" at the final analysis.Shares of Mural slumped 59% following an increase in intraday trading volume to over 3.52 million from a daily average of about 156,000.Cassava Sciences  said that topline results from its phase 3 REFOCUS-ALZ study of simufilam showed no treatment benefit for patients with mild-to-moderate Alzheimer's disease.The biotech company said the results did not meet the co-primary, secondary, and exploratory biomarker endpoints.Shares sank 33%, with intraday trading volume rising to over 13.8 million versus a daily average of about 1.96 million.Price: 1.53, Change: -2.30, Percent Change: -60.05","market":"fut","thumbnail":null,"type":0,"news_type":0,"thumbnails":[],"rights":null,"property":[],"language":"en","translate_title":"","themeId":null,"theme_name":"","theme_type":"","isJumpTheme":false,"source_url":"https://www.mtnewswires.com/","is_publish_highlight":false,"source_rank":0,"column":"","sentiment":"-1","news_top_title":null,"news_tag":"","news_rank":0,"length":0,"strategy_id":0,"source":"mtnewswires_news","symbols":["BK4585","LU0965508806.USD","LU1699723380.USD","LU0208291251.USD","BK4007","SG9999013999.USD","LU1934455194.USD","IE00BLSP4239.USD","LU1069347547.HKD","LU1585245621.USD","LU2361045086.USD","LU0266013472.USD","LU1989772923.USD","LU0238689110.USD","BK4516","LU1929549753.HKD","LU0265550359.USD","BK4534","LU1983299246.USD","LU2023250504.SGD","MRK","MURA","SAVA","LU1093756168.USD","LU1162221912.USD","LU1066051498.USD","LU1116320901.HKD","LU1291159041.SGD","LU1023059063.AUD","LU0965509101.SGD","BK4533","SG9999001176.USD","SG9999015341.SGD","LU1941712264.USD","LU0289739699.SGD","LU0006306889.USD","LU0058720904.USD","BK4588","LU2324357040.USD","SG9999001176.SGD","BK4550","LU1093756325.SGD","LU1035773651.USD","LU1066053197.SGD","LU1934455863.HKD","IE00BJT1NW94.SGD","SG9999014575.USD","LU0106261372.USD","LU0265550946.USD","IE00BLSP4452.SGD"],"gpt_icon":0},{"id":"2522600493","title":"Cassava Sciences Price Target Maintained With a $2.00/Share by HC Wainwright & Co.","url":"https://stock-news.laohu8.com/highlight/detail?id=2522600493","media":"Dow Jones","labels":[],"top":-1,"itemType":null,"share":"https://ttm.financial/m/news/2522600493?lang=en_us&edition=fundamental","pubTime":"2025-03-25 23:51","pubTimestamp":1742917860,"startTime":"0","endTime":"0","summary":"Ratings actions from Benzinga: https://www.benzinga.com/quote/SAVA/analyst-ratings \n\n\n \n\n\n  (END) Dow Jones Newswires\n\n\n  March 25, 2025 11:51 ET (15:51 GMT)","market":"sh","thumbnail":null,"type":0,"news_type":0,"thumbnails":[],"rights":null,"property":["rate"],"language":"en","translate_title":"","themeId":null,"theme_name":"","theme_type":"","isJumpTheme":false,"source_url":"https://dowjonesnews.com/newdjn/logon.aspx?AL=N","is_publish_highlight":false,"source_rank":0,"column":"","sentiment":"0","news_top_title":null,"news_tag":"","news_rank":0,"length":0,"strategy_id":0,"source":null,"symbols":["SAVA"],"gpt_icon":0},{"id":"2522000870","title":"Cassava Sciences’ Alzheimer’s Drug Trials Fall Short, Neutral Rating Maintained Amid Uncertainties","url":"https://stock-news.laohu8.com/highlight/detail?id=2522000870","media":"TIPRANKS","labels":[],"top":-1,"itemType":null,"share":"https://ttm.financial/m/news/2522000870?lang=en_us&edition=fundamental","pubTime":"2025-03-25 22:15","pubTimestamp":1742912125,"startTime":"0","endTime":"0","summary":"Vernon Bernardino, an analyst from H.C. Wainwright, reiterated the Hold rating on Cassava Sciences (SAVA – Research Report). The associated price t...","market":"fut","thumbnail":null,"type":0,"news_type":0,"thumbnails":[],"rights":{"source":"tipranks_highlight","url":"https://www.tipranks.com/news/ratings/cassava-sciences-alzheimers-drug-trials-fall-short-neutral-rating-maintained-amid-uncertainties?utm_source=itigerup.com&utm_medium=referral","rn_cache_url":null,"directOrigin":true},"property":[],"language":"en","translate_title":"","themeId":null,"theme_name":"","theme_type":"","isJumpTheme":false,"source_url":"https://www.tipranks.com/news/ratings/cassava-sciences-alzheimers-drug-trials-fall-short-neutral-rating-maintained-amid-uncertainties?utm_source=itigerup.com&utm_medium=referral","is_publish_highlight":false,"source_rank":0,"column":"","sentiment":"-1","news_top_title":null,"news_tag":"","news_rank":0,"length":0,"strategy_id":0,"source":"tipranks_highlight","symbols":["BK4585","BK4547","BK4007","SAVA","BK4588"],"gpt_icon":0},{"id":"2522008555","title":"Cassava Sciences Stock Falls as Alzheimer Drug Misses Targets, To Be Discontinued","url":"https://stock-news.laohu8.com/highlight/detail?id=2522008555","media":"Dow Jones","labels":["dataReport"],"top":-1,"itemType":null,"share":"https://ttm.financial/m/news/2522008555?lang=en_us&edition=fundamental","pubTime":"2025-03-25 22:15","pubTimestamp":1742912100,"startTime":"0","endTime":"0","summary":"Cassava Sciences' shares fell sharply Tuesday morning after the company said it would discontinue the development of its Alzheimer's treatment after recent trials didn't meet any of their objectives.Shares declined sharply, falling nearly 22% to $2.20.The clinical-stage biotechnology company said that the third phase of its Refocus-ALZ study of simufilam didn't meet any of the primary endpoints, nor any secondary and exploratory biomarker endpoints.Alzheimer's disease is a progressive brain disorder and is the leading cause of dementia. Symptoms include memory loss, decline in cognition and difficulty performing everyday tasks.The two primary endpoints for the study were to see a change in cognition and function after a 76-week period, comparing each dose of simufilam to a placebo dose.Cassava said that it will discontinue all efforts to develop simufilam and expects to phase out the program by the end of the second quarter. Still, the biotechnology company said it has begun preclinica","market":"hk","thumbnail":null,"type":0,"news_type":0,"thumbnails":[],"rights":null,"property":[],"language":"en","translate_title":"","themeId":null,"theme_name":"","theme_type":"","isJumpTheme":false,"source_url":"https://dowjonesnews.com/newdjn/logon.aspx?AL=N","is_publish_highlight":false,"source_rank":0,"column":"","sentiment":"-2","news_top_title":"Cassava Sciences Stock Falls as Alzheimer Drug Misses Targets, To Be Discontinued","news_tag":"dataReport","news_rank":0,"length":0,"strategy_id":0,"source":null,"symbols":["BK4547","BK4585","BK4588","SAVA","BK4007"],"gpt_icon":1},{"id":"2522207478","title":"Cassava Sciences Shares Drop 21% After Co to Discontinue Development of Alzheimer's Disease Drug","url":"https://stock-news.laohu8.com/highlight/detail?id=2522207478","media":"THOMSON 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drug","url":"https://stock-news.laohu8.com/highlight/detail?id=2522713660","media":"Reuters","labels":["productRelease"],"top":-1,"itemType":null,"share":"https://ttm.financial/m/news/2522713660?lang=en_us&edition=fundamental","pubTime":"2025-03-25 21:17","pubTimestamp":1742908631,"startTime":"0","endTime":"0","summary":"BUZZ-Cassava falls after stopping development of Alzheimer's drug** Shares of drug developer Cassava Sciences SAVA.O fall 21.4% to $2.20 premarket** SAVA says it will discontinue the development of its experimental treatment, simufilam, for Alzheimer's disease, by the end of Q2** In trials, the drug failed to significantly reduce cognitive or functional decline in patients with mild-to-moderate Alzheimer's disease, compared to placebo** In November, co said it would stop all trials of the drug** The drug has been at the center of scrutiny after a medical professor linked to its development was charged with fraud in June** Stock fell 89.4% since Nov 2024  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20:56","pubTimestamp":1742907386,"startTime":"0","endTime":"0","summary":"Cassava Sciences  said Tuesday that topline results from its phase 3 REFOCUS-ALZ study of simufilam showed no treatment benefit for patients with mild-to-moderate Alzheimer's disease.The biotech company said the results did not meet the co-primary, secondary, and exploratory biomarker endpoints.The co-primary endpoints were the change in cognition and function from baseline to the end of the double-blind treatment period at week 76 compared to placebo.Shares of Cassava Sciences were down 18% in recent premarket 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