7月10日，Ionis Pharmaceuticals盘中下跌6.04%，报59.59美元/股，成交额4121.97万美元，延续前一交易日超20%的暴跌走势。
消息面上，Ionis与合作伙伴阿斯利康此前宣布，其药物Eplontersen针对转甲状腺素蛋白介导的淀粉样心肌病（ATTR-CM）的三期临床试验Cardio-Ttransform未能达到主要疗效终点。试验结果显示，在大多数患者已接受稳定剂标准治疗的背景下，加用Eplontersen未能在心血管死亡及复发性心血管临床事件复合终点上提供统计学显著获益。ATTR-CM为Ionis心脏代谢管线核心适应症，此次失败构成重大挫折。此外，TD Cowen将Ionis目标价从108美元下调至94美元，维持买入评级，进一步压制市场情绪。
（以上内容均基于市场公开消息，由程序或算法智能生成，仅作为股价异动提醒，不作为投资建议或交易依据。）
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