7月23日夜盘,法国生物技术公司Abivax(ABVX)股价大涨5.67%,引发市场广泛关注。这一显著涨幅源于该公司公布了其核心药物obefazimod在治疗溃疡性结肠炎方面取得的突破性临床试验结果。
根据Abivax发布的公告,obefazimod在针对中度至重度活动性溃疡性结肠炎的ABTECT III期临床试验中取得了积极成果。试验结果显示,在8周诱导期内,obefazimod在实现临床缓解方面明显优于安慰剂。其中,50mg剂量组实现了16.4%的安慰剂校正临床缓解率,具有高度统计学显著性和临床意义。
这一突破性进展不仅为溃疡性结肠炎患者带来新的治疗希望,也大大提升了投资者对Abivax前景的信心。公司表示计划在2026年下半年向美国食品药品监督管理局(FDA)提交新药申请。值得注意的是,obefazimod作为一种口服小分子药物,其独特的作用机制使其有潜力用于治疗多种炎症性疾病,这进一步扩大了该药物的市场前景。
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