7月9日，Ionis Pharmaceuticals盘中下跌20.03%，报67.55美元/股，成交额5.38亿美元。
消息面上，Ionis与合作伙伴阿斯利康宣布，其药物Eplontersen针对转甲状腺素蛋白介导的淀粉样心肌病（ATTR-CM）的三期临床试验Cardio-Ttransform未能达到主要疗效终点。该终点为截至第140周的心血管死亡及复发性心血管临床事件复合结局。声明指出，在大多数患者已使用稳定剂的标准治疗基础上，加用Eplontersen未能提供统计学显著获益。
ATTR-CM是Ionis心脏代谢管线的核心适应症之一，此次试验失败对公司该领域布局构成重大挫折。Ionis与阿斯利康计划继续分析完整数据，并将于8月欧洲心脏病学会大会上公布详细结果。受同一消息拖累，阿斯利康盘前亦跌超8%。
（以上内容均基于市场公开消息，由程序或算法智能生成，仅作为股价异动提醒，不作为投资建议或交易依据。）
Disclaimer: Investing carries risk. This is not financial advice. The above content should not be regarded as an offer, recommendation, or solicitation on acquiring or disposing of any financial products, any associated discussions, comments, or posts by author or other users should not be considered as such either. It is solely for general information purpose only, which does not consider your own investment objectives, financial situations or needs. TTM assumes no responsibility or warranty for the accuracy and completeness of the information, investors should do their own research and may seek professional advice before investing.