CARSGEN-B (02171) announced that it will present clinical data for CT0596, a BCMA-targeting allogeneic CAR-T cell candidate, at the 67th American Society of Hematology (ASH) Annual Meeting. The abstract and additional information will be released after November 3, 2025, Eastern Time.
CT0596 is a universal CAR-T cell therapy targeting BCMA, developed based on CARSGEN's proprietary THANK-u Plus™ platform, and is currently undergoing investigator-initiated clinical trials in relapsed/refractory multiple myeloma (R/R MM) or plasma cell leukemia (PCL). CT0596 has demonstrated preliminary favorable safety profile and encouraging efficacy signals, with CAR-T cell expansion observed across all predetermined dose groups.
Beyond R/R MM, the company also plans to further explore CT0596 in other plasma cell malignancies as well as autoreactive plasma cell-driven autoimmune diseases. The company anticipates submitting an IND application for this product candidate in the second half of 2025.