Akeso's stock plummeted 5.07% during intraday trading, extending recent declines for the biopharmaceutical company.
The sharp drop follows market digestion of disappointing interim results from the global pivotal Phase III HARMONi-3 study of its drug ivonescimab. The data showed that the squamous cell carcinoma cohort for the first-line treatment of metastatic non-small cell lung cancer failed to meet the pre-specified statistical significance threshold, raising significant concerns among investors about whether the strong clinical results observed in the Chinese patient population can be replicated globally.
The news has led to a sustained sell-off, with the stock having retreated over 26% from its April high, and contributed to broader pressure on the biotech sector during the session.