再生元制药公司宣布，其与赛诺菲联合开发的Dupixent在临床试验中取得突破性进展。数据显示，治疗24周后，患者食管扩张性指标较基线水平显著提升9%。
该结果来自针对嗜酸性粒细胞性食管炎患者的III期研究。食管扩张性改善意味着患者吞咽功能得到实质性恢复，这对长期受进食困难困扰的患者具有重要临床意义。
Dupixent作为全人源单克隆抗体，通过抑制IL-4和IL-13信号通路发挥治疗作用。此次研究还观察到患者组织学异常和症状评分均获得显著改善。
这项突破为嗜酸性粒细胞性食管炎患者提供了新的治疗选择。目前该适应症尚未获得监管批准，相关数据将作为申报材料提交给药品监管机构。
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