Annovis Bio, Inc.（ANVS）近日宣布，其独立数据安全监测委员会（DSMB）已正式批准公司推进Buntanetap在阿尔茨海默病治疗中的关键三期临床试验。这一重要监管节点为Annovis在神经退行性疾病领域的临床开发计划扫清了道路。
Buntanetap作为一种口服小分子药物，旨在通过降低神经毒性蛋白水平来减缓阿尔茨海默病的病理进程。此次三期试验将评估该药物对早期阿尔茨海默病患者的认知功能改善效果与安全性。
DSMB的批准基于对二期临床试验数据的全面审查，结果显示Buntanetap在主要终点指标上表现出显著疗效，且未出现重大安全性问题。该决定意味着试验方案符合伦理与科学标准，可继续按计划招募患者。
Annovis计划在全球多个临床中心开展这项随机、双盲、安慰剂对照的三期研究，预计将纳入约450名患者。公司强调，这一进展标志着Buntanetap成为潜在阿尔茨海默病疗法的重要里程碑。
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