IDEAYA Biosciences宣布，其计划在2026年下半年启动一项1期联合治疗队列研究。该研究将评估IDEAYA在研药物与罗氏（Roche）旗下RG6505的组合疗法，目标适应症为MTAP基因缺失且携带RAS突变的胰腺导管腺癌（PDAC）。
这一临床布局标志着IDEAYA在肿瘤精准医疗领域的又一关键推进。通过靶向特定基因特征的肿瘤类型，联合用药策略有望为这一难治性癌症患者群体带来新的治疗选择。
值得注意的是，该研究设计聚焦于双重生物标志物筛选，即同时满足MTAP缺失与RAS突变条件的患者。这种严格的入组标准反映出精准医学时代下，临床试验正日益向分子分型驱动的方向发展。
IDEAYA方面暂未披露更多关于该队列的具体剂量方案或患者招募细节，但此次与罗氏的合作无疑将为双方在肿瘤免疫联合疗法领域积累宝贵的数据与经验。
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