康方生物-B(09926):AK112Ia期最初剂量递增阶段的临床研究结果令人鼓舞

智通财经网
Nov 02, 2020

康方生物-B(09926)发布公告,该公司核心自主研发的新药PD-1/VEGF双特异性抗体(研发代号:AK112)Ia期临床研究阶段性数据已在2020中国肿瘤免疫治疗会议上发布。

公告称,目前AK112已经在澳洲和中国开展Ia期临床研究,最初剂量递增阶段的临床研究结果令人鼓舞。研究的结果显示,在有至少经历过一次肿瘤评估并对PD-1抑制剂不敏感或接受过PD-1抑制剂治疗的11例晚期实体瘤患者中,共有4例达到了缓解(客观缓解率(ORR):36 %),共7例肿瘤缩小且疾病稳定(疾病控制率(DCR):64%)。

这表明PD-1/VEGF双抗(AK112)有潜力成为突破性的疗法,为PD-1抑制剂不敏感或接受过PD-1抑制剂治疗的病人带来新的希望。

PD-1抑制剂与VEGF抑制剂的联合疗法已在多个瘤种(如肾细胞癌、非小细胞肺癌和肝细胞癌)中展现出显著的疗效。AK112是公司自主研发、全球首个进入临床研究的PD-1/VEGF双特异性抗体。

AK112是基于公司独特的TETRABODY技术设计,可阻断PD-1与PD-L1和PD-L2 的结合,并同时阻断VEGF与VEGF受体的结合。鉴于VEGF和PD-1在肿瘤微环境中的共表达,与联合疗法相比,AK112作为单一药物同时阻断这两个靶点,可能会更有效地阻断这两个通路从而增强抗肿瘤活性。

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