Prime Medicine的技术将Prime Editing与整合酶或其他位点特异性重组酶相结合，将大基因货物引入基因组，以实现稳定的货物表达。PASSIGE通过完全非病毒的制造过程递送，不会引入双链DNA断裂或脱靶编辑，并且可以实现更精确有效的基因修饰。
Prime Medicine 总裁兼首席执行官Keith Gottesdiener博士表示：“此次合作将利用我们的PASSIGE技术，这将推动一步式、非病毒、数千碱基大小的基因编辑方法进入临床。PASSIGE和Prime Editing有巨大的机会彻底改变细胞治疗领域，我们期待通过内部和合作努力扩大我们的影响力。”
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